PMID- 37263238
OWN - NLM
STAT- MEDLINE
DCOM- 20230809
LR  - 20230921
IS  - 1662-2782 (Electronic)
IS  - 0302-5144 (Linking)
VI  - 200
DP  - 2023
TI  - Anticoagulation Prophylaxis in Extracorporeal Adsorption Techniques.
PG  - 82-87
LID - 10.1159/000527572 [doi]
AB  - In this chapter, anticoagulation treatments for adsorption techniques in 
      continuous renal replacement therapy (CKRT) will be reviewed. Anticoagulation 
      used with adsorption techniques is quite different than anticoagulation in 
      classical CKRT with nonadsorptive therapies. Regional citrate anticoagulation 
      (RCA) and unfractionated heparin (UFH) are the most common anticoagulation 
      modalities for both nonselective adsorptive membranes - such as surface-treated 
      acrylonitrile 69 membranes (AN69ST) and polymethylmethacrylate membranes - and 
      selective adsorptive membranes such as AN69-oXiris. For these techniques, the 
      efficacy of RCA seems to be superior to UFH. Regardless of the lack of large 
      comparative studies in comparison to ones conducted for adsorptive filter 
      techniques in CKRT, RCA and UFH will also be discussed for nonselective 
      adsorptive sorbents like CytoSorb and Jafron HA. For selective adsorptive 
      sorbents, such as polymyxin-B hemoperfusion, UFH and RCA seems to be the 
      appropriate techniques; however, randomized controlled trials confirming this are 
      yet to be conducted. Lastly, anticoagulation prophylaxis for more specific 
      techniques like coupled plasma filtration adsorption and double plasma molecular 
      adsorption system will be discussed.
CI  - (c) 2023 S. Karger AG, Basel.
FAU - Honore, Patrick M
AU  - Honore PM
AD  - CHU UCL Godinne Namur, UCL Louvain Medical Shool, Campus Godinne, Namur, Belgium.
FAU - Blackman, Sydney
AU  - Blackman S
AD  - ULB University, Brussels, Belgium.
FAU - Bousbiat, Ibrahim
AU  - Bousbiat I
AD  - ULB University, Brussels, Belgium.
FAU - Perriens, Emily
AU  - Perriens E
AD  - ULB University, Brussels, Belgium.
FAU - Attou, Rachid
AU  - Attou R
AD  - Faculty of Medicine, ICU Department, Centre Hospitalier Universitaire Brugmann, 
      ULB University, Brussels, Belgium.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20230601
PL  - Switzerland
TA  - Contrib Nephrol
JT  - Contributions to nephrology
JID - 7513582
RN  - 9005-49-6 (Heparin)
RN  - 2968PHW8QP (Citric Acid)
RN  - 0 (Citrates)
RN  - 0 (Anticoagulants)
SB  - IM
MH  - Humans
MH  - *Heparin/pharmacology/therapeutic use
MH  - Adsorption
MH  - *Blood Coagulation
MH  - Citric Acid
MH  - Citrates
MH  - Anticoagulants/therapeutic use
EDAT- 2023/06/02 01:07
MHDA- 2023/08/09 06:43
CRDT- 2023/06/01 18:24
PHST- 2022/07/03 00:00 [received]
PHST- 2022/09/23 00:00 [accepted]
PHST- 2023/08/09 06:43 [medline]
PHST- 2023/06/02 01:07 [pubmed]
PHST- 2023/06/01 18:24 [entrez]
AID - 000527572 [pii]
AID - 10.1159/000527572 [doi]
PST - ppublish
SO  - Contrib Nephrol. 2023;200:82-87. doi: 10.1159/000527572. Epub 2023 Jun 1.