PMID- 37264961
OWN - NLM
STAT- MEDLINE
DCOM- 20230605
LR  - 20230611
IS  - 1791-2431 (Electronic)
IS  - 1021-335X (Print)
IS  - 1021-335X (Linking)
VI  - 50
IP  - 1
DP  - 2023 Jul
TI  - GC‑MSC‑derived circ_0024107 promotes gastric cancer cell lymphatic metastasis via 
      fatty acid oxidation metabolic reprogramming mediated by the 
      miR‑5572/6855‑5p/CPT1A axis.
LID - 138 [pii]
LID - 10.3892/or.2023.8575 [doi]
AB  - Gastric cancer tissue‑derived mesenchymal stem cells (GC‑MSCs) play a critical 
      role in facilitating gastric cancer metastasis. Recently, circular RNAs 
      (circRNAs) and metabolic reprogramming have been found to be extensively involved 
      in the malignant progression of tumors, including gastric cancer. However, the 
      biological role and potential mechanisms of GC‑MSC‑derived circRNAs in metabolic 
      reprogramming remain elusive. Herein, the expression profiles of circRNAs and 
      mRNAs were compared between GC‑MSCs and bone marrow‑derived MSCs (BM‑MSCs) using 
      microarray analysis. circ_0024107 was identified to mediate GC‑MSCs to promote 
      gastric cancer lymphatic metastasis by inducing fatty acid oxidation (FAO) 
      metabolic reprogramming. Mechanistically, circ_0024107 served as a sponge of 
      miR‑5572 and miR‑6855‑5p to elicit the FAO metabolic reprograming of GC‑MSCs by 
      upregulating carnitine palmitoyltransferase 1A (CPT1A). In addition, GC‑MSCs 
      promoted metastasis which was dependent on the induction of FAO in gastric cancer 
      cells mediated by circ_0024107. The circ_0024107/miR‑5572/6855‑5p/CPT1A axis was 
      deregulated in gastric cancer tissues and GC‑MSCs, and was associated with lymph 
      node metastasis and the prognosis of patients with gastric cancer. Taken 
      together, the findings of the present study suggest the crucial role of FAO 
      metabolic reprogramming mediated by GC‑MSC‑derived circ_0024107 in 
      synergistically promoting gastric cancer lymphatic metastasis via 
      miR‑5572/6855‑5p‑CPT1A signaling; this suggests that circ_0024107 may be an 
      attractive target for gastric cancer intervention.
FAU - Wang, Lin
AU  - Wang L
AD  - Department of Laboratory Medicine, School of Medicine, Jiangsu University, 
      Zhenjiang, Jiangsu 212013, P.R. China.
FAU - Wu, Chen
AU  - Wu C
AD  - Department of Laboratory Medicine, School of Medicine, Jiangsu University, 
      Zhenjiang, Jiangsu 212013, P.R. China.
FAU - Xu, Juan
AU  - Xu J
AD  - Department of Laboratory Medicine, The Affiliated Taizhou People's Hospital of 
      Nanjing Medical University, Taizhou, Jiangsu 225300, P.R. China.
FAU - Gong, Zhen
AU  - Gong Z
AD  - Department of Laboratory Medicine, School of Medicine, Jiangsu University, 
      Zhenjiang, Jiangsu 212013, P.R. China.
FAU - Cao, Xiaoli
AU  - Cao X
AD  - Department of Laboratory Medicine, Affiliated Tumor Hospital of Nantong 
      University, Nantong, Jiangsu 226001, P.R. China.
FAU - Huang, Jiaying
AU  - Huang J
AD  - Department of Laboratory Medicine, School of Medicine, Jiangsu University, 
      Zhenjiang, Jiangsu 212013, P.R. China.
FAU - Dong, Haibo
AU  - Dong H
AD  - Department of Hematology, Nanjing Drum Tower Hospital, Affiliated Hospital of 
      Jiangsu University, Nanjing, Jiangsu 210008, P.R. China.
FAU - Zhu, Wei
AU  - Zhu W
AD  - Department of Laboratory Medicine, School of Medicine, Jiangsu University, 
      Zhenjiang, Jiangsu 212013, P.R. China.
FAU - Huang, Feng
AU  - Huang F
AD  - Department of Laboratory Medicine, School of Medicine, Jiangsu University, 
      Zhenjiang, Jiangsu 212013, P.R. China.
FAU - Zhou, Chenglin
AU  - Zhou C
AD  - Department of Laboratory Medicine, The Affiliated Taizhou People's Hospital of 
      Nanjing Medical University, Taizhou, Jiangsu 225300, P.R. China.
FAU - Wang, Mei
AU  - Wang M
AD  - Department of Laboratory Medicine, School of Medicine, Jiangsu University, 
      Zhenjiang, Jiangsu 212013, P.R. China.
LA  - eng
PT  - Journal Article
DEP - 20230602
PL  - Greece
TA  - Oncol Rep
JT  - Oncology reports
JID - 9422756
RN  - 0 (RNA, Circular)
RN  - EC 2.3.1.21 (Carnitine O-Palmitoyltransferase)
RN  - 0 (MicroRNAs)
RN  - 0 (Fatty Acids)
SB  - IM
MH  - Humans
MH  - *Stomach Neoplasms/pathology
MH  - Lymphatic Metastasis/genetics
MH  - RNA, Circular/genetics/metabolism
MH  - Carnitine O-Palmitoyltransferase/genetics/metabolism
MH  - *MicroRNAs/genetics/metabolism
MH  - Fatty Acids/genetics
MH  - Gene Expression Regulation, Neoplastic
MH  - Cell Proliferation/physiology
MH  - Cell Line, Tumor
PMC - PMC10251368
OTO - NOTNLM
OT  - circular RNA
OT  - gastric cancer
OT  - lymph node metastasis
OT  - mesenchymal stem cells
OT  - tumor microenvironment
COIS- The authors declare that they have no competing interests.
EDAT- 2023/06/02 06:42
MHDA- 2023/06/05 06:42
PMCR- 2023/05/29
CRDT- 2023/06/02 05:53
PHST- 2023/01/11 00:00 [received]
PHST- 2023/05/04 00:00 [accepted]
PHST- 2023/06/05 06:42 [medline]
PHST- 2023/06/02 06:42 [pubmed]
PHST- 2023/06/02 05:53 [entrez]
PHST- 2023/05/29 00:00 [pmc-release]
AID - 138 [pii]
AID - OR-50-1-08575 [pii]
AID - 10.3892/or.2023.8575 [doi]
PST - ppublish
SO  - Oncol Rep. 2023 Jul;50(1):138. doi: 10.3892/or.2023.8575. Epub 2023 Jun 2.