PMID- 37265415
OWN - NLM
STAT- MEDLINE
DCOM- 20230810
LR  - 20230810
IS  - 1651-2227 (Electronic)
IS  - 0803-5253 (Linking)
VI  - 112
IP  - 9
DP  - 2023 Sep
TI  - Ultrasound-assessed lung aeration, oxygenation and respiratory care in neonatal 
      bile acid pneumonia: A nested case-control study.
PG  - 1898-1904
LID - 10.1111/apa.16865 [doi]
AB  - AIM: Neonatal bile acid pneumonia (NBAP) occurs in neonates following obstetric 
      cholestasis. We aimed to study the lung aeration and respiratory support of NBAP. 
      METHODS: Nested, case/control study enrolling age-matched neonates with NBAP, 
      respiratory distress syndrome (RDS) or transient tachypnoea (TTN). Lung aeration 
      and oxygenation were assessed with lung ultrasound score, oxygenation index and 
      SpO(2) /FiO(2) . RESULTS: Nineteen, 22 and 25 neonates with NBAP, RDS and TTN, 
      respectively were studied (mean gestational age = 33 (2.2) weeks, 30 (45.5%) 
      males). Upon admission, RDS patients had the worst lung ultrasound score 
      (p = 0.022) and oxygenation index (p = 0.001), while NBAP and TTN neonates had 
      similar values. At the worst time-point, NBAP and RDS patients showed similar 
      oxygenation index (NBAP: 4.6 [2], RDS: 5.7 [3]) and SpO(2) /FiO(2) (NBAP: 3.1 
      [1.1], RDS: 2.7 [1]) which were worse than those of TTN patients (oxygenation 
      index: p = 0.015, SpO(2) /FiO(2) : p = 0.001). RDS neonates needed the longest 
      continuous positive airway pressure and highest mean airway pressure, but NBAP 
      neonates needed invasive ventilation (26.3%, p = 0.01) and surfactant (31.6%, 
      p = 0.003) more often than TTN patients who never needed these. CONCLUSION: NBAP 
      was a mild disorder in the first hours of life but subsequently worsened and 
      became similar to RDS.
CI  - (c) 2023 Foundation Acta Paediatrica. Published by John Wiley & Sons Ltd.
FAU - Regiroli, Giulia
AU  - Regiroli G
AD  - Division of Paediatrics and Neonatal Critical Care, "A.Beclere" Medical Centre, 
      Paris Saclay University Hospitals, APHP, Paris, France.
AD  - Physiopathology and Therapeutic Innovation Unit-INSERM U999, Paris Saclay 
      University, Paris, France.
FAU - La Malfa, Giulia
AU  - La Malfa G
AD  - Division of Paediatrics and Neonatal Critical Care, "A.Beclere" Medical Centre, 
      Paris Saclay University Hospitals, APHP, Paris, France.
FAU - Loi, Barbara
AU  - Loi B
AD  - Division of Paediatrics and Neonatal Critical Care, "A.Beclere" Medical Centre, 
      Paris Saclay University Hospitals, APHP, Paris, France.
AD  - Physiopathology and Therapeutic Innovation Unit-INSERM U999, Paris Saclay 
      University, Paris, France.
FAU - Vivanti, Alexandre
AU  - Vivanti A
AD  - Division of Obstetrics and Gynaecology, "A.Beclere" Medical Centre, Paris Saclay 
      University Hospitals, APHP, Paris, France.
FAU - Centorrino, Roberta
AU  - Centorrino R
AD  - Division of Paediatrics and Neonatal Critical Care, "A.Beclere" Medical Centre, 
      Paris Saclay University Hospitals, APHP, Paris, France.
FAU - De Luca, Daniele
AU  - De Luca D
AUID- ORCID: 0000-0002-3846-4834
AD  - Division of Paediatrics and Neonatal Critical Care, "A.Beclere" Medical Centre, 
      Paris Saclay University Hospitals, APHP, Paris, France.
AD  - Physiopathology and Therapeutic Innovation Unit-INSERM U999, Paris Saclay 
      University, Paris, France.
LA  - eng
PT  - Journal Article
DEP - 20230612
PL  - Norway
TA  - Acta Paediatr
JT  - Acta paediatrica (Oslo, Norway : 1992)
JID - 9205968
RN  - 0 (Pulmonary Surfactants)
SB  - IM
MH  - Infant, Newborn
MH  - Male
MH  - Pregnancy
MH  - Female
MH  - Humans
MH  - Adult
MH  - Case-Control Studies
MH  - Lung/diagnostic imaging
MH  - *Respiratory Distress Syndrome, Newborn/therapy
MH  - *Pulmonary Surfactants
MH  - *Pneumonia/diagnostic imaging/therapy
OTO - NOTNLM
OT  - biliary pneumonitis
OT  - neonatal intensive care unit
OT  - obstetric cholestasis
OT  - respiratory distress
OT  - surfactant
EDAT- 2023/06/02 13:16
MHDA- 2023/08/10 06:42
CRDT- 2023/06/02 10:12
PHST- 2023/05/30 00:00 [revised]
PHST- 2023/04/05 00:00 [received]
PHST- 2023/06/01 00:00 [accepted]
PHST- 2023/08/10 06:42 [medline]
PHST- 2023/06/02 13:16 [pubmed]
PHST- 2023/06/02 10:12 [entrez]
AID - 10.1111/apa.16865 [doi]
PST - ppublish
SO  - Acta Paediatr. 2023 Sep;112(9):1898-1904. doi: 10.1111/apa.16865. Epub 2023 Jun 
      12.