PMID- 37268011
OWN - NLM
STAT- MEDLINE
DCOM- 20231116
LR  - 20231122
IS  - 1439-3646 (Electronic)
IS  - 0947-7349 (Linking)
VI  - 131
IP  - 11
DP  - 2023 Nov
TI  - Aerobic Training Increases Hippocampal Volume and Protects Cognitive Function for 
      Type 2 Diabetes Patients with Normal Cognition.
PG  - 605-614
LID - 10.1055/a-2105-0799 [doi]
AB  - AIM: To evaluate the effects of aerobic training on hippocampal volume and 
      cognitive function in patients with type 2 diabetes mellitus (T2DM) with normal 
      cognition. MATERIALS AND METHODS: One hundred patients with T2DM aged 60-75 years 
      who met inclusion criteria were randomized into the aerobic training group (n=50) 
      and control group (n=50). The aerobic training group received 1 year of aerobic 
      training, while the control group maintained their lifestyle without additional 
      exercise intervention. The primary outcomes were hippocampal volume measured by 
      MRI and Mini-mental State Examination (MMSE) score or Montreal Cognitive 
      Assessment scale (MoCA) scores. RESULTS: Eighty-two participants completed the 
      study (aerobic training group, n=40; control group, n=42). There was no 
      significant difference between the two groups at baseline (P>0.05). After one 
      year of moderate aerobic training, increase in total and right hippocampal volume 
      in the aerobic training group were significantly higher than in the control group 
      (P=0.027, P=0.043, respectively). In the aerobic group, total hippocampal volume 
      significantly increased after the intervention compared with baseline (P=0.034). 
      The between-group difference in the change of MMSE and MoCA scores was 
      statistically significant (P=0.015, P=0.027, respectively). Logistic regression 
      showed strong correlations between aerobic training and increase in total 
      hippocampal volume (OR:1.091, [95%CI 0.969, 1.228], P=0.002), improvement of MMSE 
      scores (OR:1.127, [95%CI 1.005, 1.263], P=0.041) or MoCA scores (OR:2.564, [95%CI 
      2.098.2.973], P=0.045). CONCLUSIONS: One-year moderate aerobic training increased 
      total and right hippocampal volume and protected cognitive function for T2DM 
      patients with normal cognition. Early intervention focusing on cognition 
      protection should be considered for T2DM patients in clinical settings.
CI  - Thieme. All rights reserved.
FAU - Wang, Ying
AU  - Wang Y
AD  - The First Affiliated Hospital of Hainan Medical University, Hainan Clinical 
      Research Center for Metabolic Disease, Haikou, Hainan Province, China.
FAU - Wang, Liping
AU  - Wang L
AD  - Department of Geriatrics, Affiliated Nanjing Brain Hospital, Nanjing Medical 
      University, Nanjing, Jiangsu Province, China.
FAU - Yan, Juan
AU  - Yan J
AD  - Jiangsu college of nursing, Huaian, Jiangsu Province, China.
FAU - Yuan, Xiaodan
AU  - Yuan X
AD  - Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, 
      Nanjing, University of Chinese Medicine, Nanjing, Jiangsu Province, China.
FAU - Lou, Qing Q
AU  - Lou QQ
AD  - The First Affiliated Hospital of Hainan Medical University, Hainan Clinical 
      Research Center for Metabolic Disease, Haikou, Hainan Province, China.
LA  - eng
SI  - ClinicalTrials.gov/NCT04489966
GR  - (2014-WSN-025)/the Six Talent Peaks Project/
PT  - Clinical Trial
PT  - Randomized Controlled Trial
DEP - 20230602
PL  - Germany
TA  - Exp Clin Endocrinol Diabetes
JT  - Experimental and clinical endocrinology & diabetes : official journal, German 
      Society of Endocrinology [and] German Diabetes Association
JID - 9505926
SB  - IM
MH  - Humans
MH  - *Diabetes Mellitus, Type 2/complications/therapy
MH  - Cognition
MH  - Exercise
MH  - Magnetic Resonance Imaging
MH  - Hippocampus/diagnostic imaging
MH  - *Cognitive Dysfunction
MH  - Neuropsychological Tests
COIS- The authors declare that there is no conflict of interest that could be perceived 
      as prejudicing the impartiality of the research reported.
EDAT- 2023/06/03 11:42
MHDA- 2023/11/16 06:45
CRDT- 2023/06/02 19:13
PHST- 2023/11/16 06:45 [medline]
PHST- 2023/06/03 11:42 [pubmed]
PHST- 2023/06/02 19:13 [entrez]
AID - 10.1055/a-2105-0799 [doi]
PST - ppublish
SO  - Exp Clin Endocrinol Diabetes. 2023 Nov;131(11):605-614. doi: 10.1055/a-2105-0799. 
      Epub 2023 Jun 2.