PMID- 37268716
OWN - NLM
STAT- MEDLINE
DCOM- 20230605
LR  - 20230609
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 13
IP  - 1
DP  - 2023 Jun 2
TI  - Quality of life and intrinsic capacity in patients with post-acute COVID-19 
      syndrome is in relation to frailty and resilience phenotypes.
PG  - 8956
LID - 10.1038/s41598-023-29408-z [doi]
LID - 8956
AB  - The objective of this study was to characterize frailty and resilience in people 
      evaluated for Post-Acute COVID-19 Syndrome (PACS), in relation to quality of life 
      (QoL) and Intrinsic Capacity (IC). This cross-sectional, observational, study 
      included consecutive people previously hospitalized for severe COVID-19 pneumonia 
      attending Modena (Italy) PACS Clinic from July 2020 to April 2021. Four 
      frailty-resilience phenotypes were built: "fit/resilient", "fit/non-resilient", 
      "frail/resilient" and "frail/non-resilient". Frailty and resilience were defined 
      according to frailty phenotype and Connor Davidson resilience scale (CD-RISC-25) 
      respectively. Study outcomes were: QoL assessed by means of Symptoms Short form 
      health survey (SF-36) and health-related quality of life (EQ-5D-5L) and IC by 
      means of a dedicated questionnaire. Their predictors including frailty-resilience 
      phenotypes were explored in logistic regressions. 232 patients were evaluated, 
      median age was 58.0 years. PACS was diagnosed in 173 (74.6%) patients. Scarce 
      resilience was documented in 114 (49.1%) and frailty in 72 (31.0%) individuals. 
      Predictors for SF-36 score < 61.60 were the phenotypes "frail/non-resilient" 
      (OR = 4.69, CI 2.08-10.55), "fit/non-resilient" (OR = 2.79, CI 1.00-7.73). 
      Predictors for EQ-5D-5L < 89.7% were the phenotypes "frail/non-resilient" 
      (OR = 5.93, CI 2.64-13.33) and "frail/resilient" (OR = 5.66, CI 1.93-16.54). 
      Predictors of impaired IC (below the mean score value) were "frail/non-resilient" 
      (OR = 7.39, CI 3.20-17.07), and "fit/non-resilient" (OR = 4.34, CI 2.16-8.71) 
      phenotypes. Resilience and frailty phenotypes may have a different impact on 
      wellness and QoL and may be evaluated in people with PACS to identify vulnerable 
      individuals that require suitable interventions.
CI  - (c) 2023. The Author(s).
FAU - Guaraldi, Giovanni
AU  - Guaraldi G
AD  - Department of Surgical, Medical, Dental and Morphological Sciences, University of 
      Modena and Reggio Emilia, Largo del Pozzo, 71, 41124, Modena, Italy. 
      giovanni.guaraldi@unimore.it.
AD  - Department of Infectious Diseases, Azienda Ospedaliero-Universitaria, Policlinico 
      of Modena, Modena, Italy. giovanni.guaraldi@unimore.it.
FAU - Milic, Jovana
AU  - Milic J
AD  - Department of Surgical, Medical, Dental and Morphological Sciences, University of 
      Modena and Reggio Emilia, Largo del Pozzo, 71, 41124, Modena, Italy.
FAU - Barbieri, Sara
AU  - Barbieri S
AD  - Department of Surgical, Medical, Dental and Morphological Sciences, University of 
      Modena and Reggio Emilia, Largo del Pozzo, 71, 41124, Modena, Italy.
FAU - Marchio, Tommaso
AU  - Marchio T
AD  - University of Modena and Reggio Emilia, Modena, Italy.
FAU - Caselgrandi, Agnese
AU  - Caselgrandi A
AD  - University of Modena and Reggio Emilia, Modena, Italy.
FAU - Motta, Federico
AU  - Motta F
AD  - Department of Surgical, Medical, Dental and Morphological Sciences, University of 
      Modena and Reggio Emilia, Largo del Pozzo, 71, 41124, Modena, Italy.
FAU - Beghe, Bianca
AU  - Beghe B
AD  - Respiratory Unit, Azienda Ospedaliero-Universitaria, Policlinico of Modena, 
      Modena, Italy.
AD  - Department of Medical and Surgical Sciences for Children and Adults, University 
      of Modena and Reggio Emilia, Modena, Italy.
FAU - Verduri, Alessia
AU  - Verduri A
AD  - Respiratory Unit, Azienda Ospedaliero-Universitaria, Policlinico of Modena, 
      Modena, Italy.
FAU - Belli, Michela
AU  - Belli M
AD  - Department of Surgical, Medical, Dental and Morphological Sciences, University of 
      Modena and Reggio Emilia, Largo del Pozzo, 71, 41124, Modena, Italy.
FAU - Gozzi, Licia
AU  - Gozzi L
AD  - Department of Infectious Diseases, Azienda Ospedaliero-Universitaria, Policlinico 
      of Modena, Modena, Italy.
FAU - Iadisernia, Vittorio
AU  - Iadisernia V
AD  - Department of Infectious Diseases, Azienda Ospedaliero-Universitaria, Policlinico 
      of Modena, Modena, Italy.
FAU - Faltoni, Matteo
AU  - Faltoni M
AD  - Department of Infectious Diseases, Azienda Ospedaliero-Universitaria, Policlinico 
      of Modena, Modena, Italy.
FAU - Burastero, Giulia
AU  - Burastero G
AD  - Department of Infectious Diseases, Azienda Ospedaliero-Universitaria, Policlinico 
      of Modena, Modena, Italy.
FAU - Dessilani, Andrea
AU  - Dessilani A
AD  - Department of Infectious Diseases, Azienda Ospedaliero-Universitaria, Policlinico 
      of Modena, Modena, Italy.
FAU - Del Monte, Martina
AU  - Del Monte M
AD  - Department of Infectious Diseases, Azienda Ospedaliero-Universitaria, Policlinico 
      of Modena, Modena, Italy.
FAU - Dolci, Giovanni
AU  - Dolci G
AD  - Department of Infectious Diseases, Azienda Ospedaliero-Universitaria, Policlinico 
      of Modena, Modena, Italy.
FAU - Bacca, Erica
AU  - Bacca E
AD  - Department of Infectious Diseases, Azienda Ospedaliero-Universitaria, Policlinico 
      of Modena, Modena, Italy.
FAU - Franceschi, Giacomo
AU  - Franceschi G
AD  - Department of Infectious Diseases, Azienda Ospedaliero-Universitaria, Policlinico 
      of Modena, Modena, Italy.
FAU - Yaacoub, Dina
AU  - Yaacoub D
AD  - Department of Infectious Diseases, Azienda Ospedaliero-Universitaria, Policlinico 
      of Modena, Modena, Italy.
FAU - Volpi, Sara
AU  - Volpi S
AD  - Department of Infectious Diseases, Azienda Ospedaliero-Universitaria, Policlinico 
      of Modena, Modena, Italy.
FAU - Mazzochi, Alice
AU  - Mazzochi A
AD  - Department of Infectious Diseases, Azienda Ospedaliero-Universitaria, Policlinico 
      of Modena, Modena, Italy.
FAU - Clini, Enrico
AU  - Clini E
AD  - Respiratory Unit, Azienda Ospedaliero-Universitaria, Policlinico of Modena, 
      Modena, Italy.
AD  - Department of Medical and Surgical Sciences for Children and Adults, University 
      of Modena and Reggio Emilia, Modena, Italy.
FAU - Mussini, Cristina
AU  - Mussini C
AD  - Department of Surgical, Medical, Dental and Morphological Sciences, University of 
      Modena and Reggio Emilia, Largo del Pozzo, 71, 41124, Modena, Italy.
AD  - Department of Infectious Diseases, Azienda Ospedaliero-Universitaria, Policlinico 
      of Modena, Modena, Italy.
LA  - eng
PT  - Journal Article
PT  - Observational Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20230602
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
SB  - IM
MH  - Humans
MH  - Aged
MH  - *Frailty
MH  - Frail Elderly
MH  - Quality of Life
MH  - Cross-Sectional Studies
MH  - Post-Acute COVID-19 Syndrome
MH  - Geriatric Assessment
MH  - *COVID-19
PMC - PMC10235830
COIS- The authors declare no competing interests.
EDAT- 2023/06/03 11:42
MHDA- 2023/06/05 06:42
PMCR- 2023/06/02
CRDT- 2023/06/02 23:21
PHST- 2022/08/13 00:00 [received]
PHST- 2023/02/03 00:00 [accepted]
PHST- 2023/06/05 06:42 [medline]
PHST- 2023/06/03 11:42 [pubmed]
PHST- 2023/06/02 23:21 [entrez]
PHST- 2023/06/02 00:00 [pmc-release]
AID - 10.1038/s41598-023-29408-z [pii]
AID - 29408 [pii]
AID - 10.1038/s41598-023-29408-z [doi]
PST - epublish
SO  - Sci Rep. 2023 Jun 2;13(1):8956. doi: 10.1038/s41598-023-29408-z.