PMID- 37270633
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230606
IS  - 2057-3995 (Electronic)
IS  - 2057-3995 (Linking)
VI  - 8
IP  - 1
DP  - 2023 Jun 3
TI  - Janus porous polylactic acid membranes with versatile metal-phenolic interface 
      for biomimetic periodontal bone regeneration.
PG  - 28
LID - 10.1038/s41536-023-00305-3 [doi]
LID - 28
AB  - Conventional treatment to periodontal and many other bone defects requires the 
      use of barrier membranes to guided tissue regeneration (GTR) and guided bone 
      regeneration (GBR). However, current barrier membranes normally lack of the 
      ability to actively regulate the bone repairing process. Herein, we proposed a 
      biomimetic bone tissue engineering strategy enabled by a new type of Janus porous 
      polylactic acid membrane (PLAM), which was fabricated by combining unidirectional 
      evaporation-induced pore formation with subsequent self-assembly of a bioactive 
      metal-phenolic network (MPN) nanointerface. The prepared PLAM-MPN simultaneously 
      possesses barrier function on the dense side and bone-forming function on the 
      porous side. In vitro, the presence of MPN nanointerface potently alleviated the 
      proinflammatory polarization of mice bone marrow-derived macrophages (BMDMs), 
      induced angiogenesis of human umbilical vein endothelial cells (HUVECs), and 
      enhanced the attachment, migration and osteogenic differentiation of human 
      periodontal ligament stem cells (hPDLSCs). The implantation of PLAM-MPN into rat 
      periodontal bone defects remarkably enhanced bone regeneration. This bioactive 
      MPN nanointerface within a Janus porous membrane possesses versatile capacities 
      to regulate cell physiology favoring bone regeneration, demonstrating great 
      potential as GTR and GBR membranes for clinical applications.
CI  - (c) 2023. The Author(s).
FAU - Zhang, Yaping
AU  - Zhang Y
AD  - Department of Biomaterials, School and Hospital of Stomatology, Cheeloo College 
      of Medicine, Shandong University & Shandong Key Laboratory of Oral Tissue 
      Regeneration & Shandong Engineering Laboratory for Dental Materials and Oral 
      Tissue Regeneration & Shandong Provincial Clinical Research Center for Oral 
      Diseases, Jinan, China.
AD  - Department of Orthodontics, The First Affiliated Hospital of Zhengzhou 
      University, (Stomatological Hospital of Henan Province), Zhengzhou, China.
FAU - Chen, Yi
AU  - Chen Y
AD  - Department of Biomaterials, School and Hospital of Stomatology, Cheeloo College 
      of Medicine, Shandong University & Shandong Key Laboratory of Oral Tissue 
      Regeneration & Shandong Engineering Laboratory for Dental Materials and Oral 
      Tissue Regeneration & Shandong Provincial Clinical Research Center for Oral 
      Diseases, Jinan, China.
FAU - Ding, Tian
AU  - Ding T
AD  - Department of Biomaterials, School and Hospital of Stomatology, Cheeloo College 
      of Medicine, Shandong University & Shandong Key Laboratory of Oral Tissue 
      Regeneration & Shandong Engineering Laboratory for Dental Materials and Oral 
      Tissue Regeneration & Shandong Provincial Clinical Research Center for Oral 
      Diseases, Jinan, China.
FAU - Zhang, Yandi
AU  - Zhang Y
AD  - Department of Biomaterials, School and Hospital of Stomatology, Cheeloo College 
      of Medicine, Shandong University & Shandong Key Laboratory of Oral Tissue 
      Regeneration & Shandong Engineering Laboratory for Dental Materials and Oral 
      Tissue Regeneration & Shandong Provincial Clinical Research Center for Oral 
      Diseases, Jinan, China.
FAU - Yang, Daiwei
AU  - Yang D
AD  - Department of Biomaterials, School and Hospital of Stomatology, Cheeloo College 
      of Medicine, Shandong University & Shandong Key Laboratory of Oral Tissue 
      Regeneration & Shandong Engineering Laboratory for Dental Materials and Oral 
      Tissue Regeneration & Shandong Provincial Clinical Research Center for Oral 
      Diseases, Jinan, China.
FAU - Zhao, Yajun
AU  - Zhao Y
AD  - Department of Biomaterials, School and Hospital of Stomatology, Cheeloo College 
      of Medicine, Shandong University & Shandong Key Laboratory of Oral Tissue 
      Regeneration & Shandong Engineering Laboratory for Dental Materials and Oral 
      Tissue Regeneration & Shandong Provincial Clinical Research Center for Oral 
      Diseases, Jinan, China.
FAU - Liu, Jin
AU  - Liu J
AD  - Department of Biomaterials, School and Hospital of Stomatology, Cheeloo College 
      of Medicine, Shandong University & Shandong Key Laboratory of Oral Tissue 
      Regeneration & Shandong Engineering Laboratory for Dental Materials and Oral 
      Tissue Regeneration & Shandong Provincial Clinical Research Center for Oral 
      Diseases, Jinan, China.
FAU - Ma, Baojin
AU  - Ma B
AD  - Department of Biomaterials, School and Hospital of Stomatology, Cheeloo College 
      of Medicine, Shandong University & Shandong Key Laboratory of Oral Tissue 
      Regeneration & Shandong Engineering Laboratory for Dental Materials and Oral 
      Tissue Regeneration & Shandong Provincial Clinical Research Center for Oral 
      Diseases, Jinan, China.
FAU - Bianco, Alberto
AU  - Bianco A
AD  - CNRS, Immunology, Immunopathology and Therapeutic Chemistry, UPR 3572, University 
      of Strasbourg, ISIS, Strasbourg, France.
FAU - Ge, Shaohua
AU  - Ge S
AD  - Department of Biomaterials, School and Hospital of Stomatology, Cheeloo College 
      of Medicine, Shandong University & Shandong Key Laboratory of Oral Tissue 
      Regeneration & Shandong Engineering Laboratory for Dental Materials and Oral 
      Tissue Regeneration & Shandong Provincial Clinical Research Center for Oral 
      Diseases, Jinan, China. shaohuage@sdu.edu.cn.
FAU - Li, Jianhua
AU  - Li J
AUID- ORCID: 0000-0001-5227-8627
AD  - Department of Biomaterials, School and Hospital of Stomatology, Cheeloo College 
      of Medicine, Shandong University & Shandong Key Laboratory of Oral Tissue 
      Regeneration & Shandong Engineering Laboratory for Dental Materials and Oral 
      Tissue Regeneration & Shandong Provincial Clinical Research Center for Oral 
      Diseases, Jinan, China. jianhua.li@sdu.edu.cn.
LA  - eng
GR  - 82001042/National Natural Science Foundation of China (National Science 
      Foundation of China)/
GR  - 81873716/National Natural Science Foundation of China (National Science 
      Foundation of China)/
GR  - tsqn201909180/Taishan Scholar Foundation of Shandong Province/
PT  - Journal Article
DEP - 20230603
PL  - United States
TA  - NPJ Regen Med
JT  - NPJ Regenerative medicine
JID - 101699846
PMC - PMC10239453
COIS- The authors declare no conflict of interest. Figures were created with BioRender 
      software (https://biorender.com).
EDAT- 2023/06/04 01:08
MHDA- 2023/06/04 01:09
PMCR- 2023/06/03
CRDT- 2023/06/03 23:25
PHST- 2023/01/14 00:00 [received]
PHST- 2023/05/23 00:00 [accepted]
PHST- 2023/06/04 01:09 [medline]
PHST- 2023/06/04 01:08 [pubmed]
PHST- 2023/06/03 23:25 [entrez]
PHST- 2023/06/03 00:00 [pmc-release]
AID - 10.1038/s41536-023-00305-3 [pii]
AID - 305 [pii]
AID - 10.1038/s41536-023-00305-3 [doi]
PST - epublish
SO  - NPJ Regen Med. 2023 Jun 3;8(1):28. doi: 10.1038/s41536-023-00305-3.