PMID- 37270990 OWN - NLM STAT- MEDLINE DCOM- 20230717 LR - 20230718 IS - 1872-7654 (Electronic) IS - 0301-2115 (Linking) VI - 287 DP - 2023 Aug TI - ATP-binding cassette transporter G1 (ABCG1) polymorphisms in pregnant women with gestational diabetes mellitus. PG - 20-28 LID - S0301-2115(23)00223-3 [pii] LID - 10.1016/j.ejogrb.2023.05.033 [doi] AB - CONTEXT AND OBJECTIVES: Gestational diabetes mellitus (GDM) is the most common metabolic disorder in pregnancy, and it often leads to adverse pregnancy outcomes and seriously harms the health of mothers and infants. ATP-binding cassette transporter G1 (ABCG1) plays critical roles in high-density lipoprotein (HDL) metabolism and reverse cholesterol transport. This study was designed to explore the relevance of the ABCG1 polymorphisms in the atherometabolic risk in GDM. STUDY DESIGN: The case-control population consists of 1504 subjects. The rs2234715 and rs57137919 single nucleotide polymorphisms (SNPs) were genotyped using PCR and DNA sequencing, and clinical and metabolic parameters were determined. RESULTS: The genotype distributions of the two SNPs showed no difference between the GDM patient and control groups. However, the rs57137919 polymorphism was associated with total cholesterol (TC), and diastolic blood pressure (DBP) levels in patients with GDM. Moreover, subgroup analysis showed that this polymorphism was associated with ApoA1 and DBP levels in overweight/obese patients with GDM, while it was associated with TC, and gestational weight gain (GWG) in non-obese patients with GDM. Meanwhile, the rs2234715 polymorphism was found to be associated with neonatal birth height in non-obese patients with GDM. CONCLUSIONS: The two polymorphisms in the ABCG1 have an influence on atherometabolic traits, GWG, and fetal growth in GDM, depending on the BMI of the patients. CI - Copyright (c) 2023 Elsevier B.V. All rights reserved. FAU - Liu, Sixu AU - Liu S AD - Laboratory of Genetic Disease and Perinatal Medicine and Key Laboratory of Birth Defects and Related Diseases of Women and Children of the Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu 610041, Sichuan, PR China; West China School of Nursing, Sichuan University, Chengdu 610041, Sichuan, PR China. FAU - Guan, Linbo AU - Guan L AD - Laboratory of Genetic Disease and Perinatal Medicine and Key Laboratory of Birth Defects and Related Diseases of Women and Children of the Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu 610041, Sichuan, PR China. FAU - Liu, Xinghui AU - Liu X AD - Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu 610041, Sichuan, PR China. FAU - Fan, Ping AU - Fan P AD - Laboratory of Genetic Disease and Perinatal Medicine and Key Laboratory of Birth Defects and Related Diseases of Women and Children of the Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu 610041, Sichuan, PR China. FAU - Zhou, Mi AU - Zhou M AD - Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu 610041, Sichuan, PR China. FAU - Wu, Yujie AU - Wu Y AD - Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu 610041, Sichuan, PR China. FAU - Liu, Rui AU - Liu R AD - Division of Peptides Related with Human Disease, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, PR China. FAU - Tang, Fangmei AU - Tang F AD - Laboratory of Genetic Disease and Perinatal Medicine and Key Laboratory of Birth Defects and Related Diseases of Women and Children of the Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu 610041, Sichuan, PR China; West China School of Nursing, Sichuan University, Chengdu 610041, Sichuan, PR China. FAU - Wang, Yufeng AU - Wang Y AD - Laboratory of Genetic Disease and Perinatal Medicine and Key Laboratory of Birth Defects and Related Diseases of Women and Children of the Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu 610041, Sichuan, PR China. FAU - Li, Dehua AU - Li D AD - Laboratory of Genetic Disease and Perinatal Medicine and Key Laboratory of Birth Defects and Related Diseases of Women and Children of the Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu 610041, Sichuan, PR China; West China School of Nursing, Sichuan University, Chengdu 610041, Sichuan, PR China. FAU - Bai, Huai AU - Bai H AD - Laboratory of Genetic Disease and Perinatal Medicine and Key Laboratory of Birth Defects and Related Diseases of Women and Children of the Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu 610041, Sichuan, PR China. Electronic address: baihuai60@aliyun.com. LA - eng PT - Journal Article DEP - 20230530 PL - Ireland TA - Eur J Obstet Gynecol Reprod Biol JT - European journal of obstetrics, gynecology, and reproductive biology JID - 0375672 RN - 0 (ATP-Binding Cassette Transporters) RN - 97C5T2UQ7J (Cholesterol) RN - 0 (ABCG1 protein, human) RN - 0 (ATP Binding Cassette Transporter, Subfamily G, Member 1) SB - IM MH - Infant, Newborn MH - Humans MH - Female MH - Pregnancy MH - *Diabetes, Gestational/epidemiology MH - Pregnant Women MH - ATP-Binding Cassette Transporters/genetics MH - Pregnancy Outcome MH - Cholesterol MH - Body Mass Index MH - ATP Binding Cassette Transporter, Subfamily G, Member 1/genetics/metabolism OTO - NOTNLM OT - ABCG1 gene OT - Atherometabolic traits OT - Genetic variations OT - Gestational diabetes mellitus OT - Obesity COIS- Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2023/06/05 00:42 MHDA- 2023/07/17 06:42 CRDT- 2023/06/04 18:05 PHST- 2022/10/17 00:00 [received] PHST- 2023/05/13 00:00 [revised] PHST- 2023/05/25 00:00 [accepted] PHST- 2023/07/17 06:42 [medline] PHST- 2023/06/05 00:42 [pubmed] PHST- 2023/06/04 18:05 [entrez] AID - S0301-2115(23)00223-3 [pii] AID - 10.1016/j.ejogrb.2023.05.033 [doi] PST - ppublish SO - Eur J Obstet Gynecol Reprod Biol. 2023 Aug;287:20-28. doi: 10.1016/j.ejogrb.2023.05.033. Epub 2023 May 30.