PMID- 37271588
OWN - NLM
STAT- MEDLINE
DCOM- 20230717
LR  - 20230718
IS  - 1879-1166 (Electronic)
IS  - 0198-8859 (Linking)
VI  - 84
IP  - 8
DP  - 2023 Aug
TI  - HLA-G susceptibility to hepatitis B infection and related hepatocellular 
      carcinoma in the Japanese population.
PG  - 401-407
LID - S0198-8859(23)00071-X [pii]
LID - 10.1016/j.humimm.2023.05.002 [doi]
AB  - AIMS: Human leukocyte antigen (HLA)-G plays a role in various physiological 
      immunomodulatory functions. Aberrant HLA-G expression is observed in various 
      disease states, including tumors, autoimmune disorders, and viral infections. The 
      present study investigated the association between HLA-G functional gene 
      polymorphisms (rs1736933 [-486 C > A], rs1049033 [+2018 C > T], 14 bp Insertion 
      [Ins]/Deletion [Del] [+2961 Del > Ins], and rs1063320 [+3142 C > G]) and disease 
      susceptibility, hepatocellular carcinoma (HCC) development, and hepatitis B 
      surface antigen (HBsAg) clearance. METHODS: Allele discrimination of the 3 SNPs 
      (-486 C > A, +2018 C > T, +3142 C > G) was determined by a TaqMan 5' exonuclease 
      assay, while the 14 bp Ins/Del polymorphism was typed by fragment analysis using 
      Genetic Analyzer and GeneMapper software. The above polymorphisms were analyzed 
      for 325 Japanese hepatitis B virus (HBV) patients, 355 Japanese healthy subjects 
      (Controls) as healthy controls, and 799 Japanese hepatitis C virus (HCV) patients 
      as disease controls, respectively. RESULTS: The 14 bp Insertion allele was 
      significantly more frequent in HBV patients than Controls (27.1 % vs 20.6 %, odds 
      ratio [OR] 1.43, P = 0.005) but did not differ between HCV patients and Controls. 
      Similar results were found for the rs1063320 G allele (38.9 % vs 26.3 %, OR 1.78, 
      P < 0.001) and the rs1736933 T allele (32.2 % vs 26.9 %, OR 1.29, P = 0.034) 
      between HBV and Controls. The rs1049033 T allele showed a weak but significant 
      association with HCC development in the dominant model (OR 1.95, P = 0.04). 
      Regarding HBsAg clearance, the A allele at rs1736933 was significantly correlated 
      in the recessive model (OR 3.23, P = 0.003). CONCLUSIONS: This study revealed 
      significant associations of HLA-G gene polymorphisms with disease susceptibility, 
      HCC development, and HBsAg clearance in HBV patients.
CI  - Copyright (c) 2023 American Society for Histocompatibility and Immunogenetics. 
      Published by Elsevier Inc. All rights reserved.
FAU - Okumura, Taiki
AU  - Okumura T
AD  - Department of Medicine, Division of Gastroenterology and Hepatology, Shinshu 
      University School of Medicine, Matsumoto, Japan.
FAU - Joshita, Satoru
AU  - Joshita S
AD  - Department of Medicine, Division of Gastroenterology and Hepatology, Shinshu 
      University School of Medicine, Matsumoto, Japan; Department of Health Promotion 
      Medicine, Shinshu University School of Medicine, Matsumoto, Japan. Electronic 
      address: joshita@shinshu-u.ac.jp.
FAU - Yamazaki, Tomoo
AU  - Yamazaki T
AD  - Department of Medicine, Division of Gastroenterology and Hepatology, Shinshu 
      University School of Medicine, Matsumoto, Japan.
FAU - Iwadare, Takanobu
AU  - Iwadare T
AD  - Department of Medicine, Division of Gastroenterology and Hepatology, Shinshu 
      University School of Medicine, Matsumoto, Japan.
FAU - Wakabayashi, Shun-Ichi
AU  - Wakabayashi SI
AD  - Department of Medicine, Division of Gastroenterology and Hepatology, Shinshu 
      University School of Medicine, Matsumoto, Japan.
FAU - Kobayashi, Hiroyuki
AU  - Kobayashi H
AD  - Department of Medicine, Division of Gastroenterology and Hepatology, Shinshu 
      University School of Medicine, Matsumoto, Japan; Department of Health Promotion 
      Medicine, Shinshu University School of Medicine, Matsumoto, Japan.
FAU - Yamashita, Yuki
AU  - Yamashita Y
AD  - Department of Medicine, Division of Gastroenterology and Hepatology, Shinshu 
      University School of Medicine, Matsumoto, Japan.
FAU - Sugiura, Ayumi
AU  - Sugiura A
AD  - Department of Medicine, Division of Gastroenterology and Hepatology, Shinshu 
      University School of Medicine, Matsumoto, Japan.
FAU - Kimura, Takefumi
AU  - Kimura T
AD  - Department of Medicine, Division of Gastroenterology and Hepatology, Shinshu 
      University School of Medicine, Matsumoto, Japan.
FAU - Ota, Masao
AU  - Ota M
AD  - Department of Medicine, Division of Gastroenterology and Hepatology, Shinshu 
      University School of Medicine, Matsumoto, Japan; Department of Health Promotion 
      Medicine, Shinshu University School of Medicine, Matsumoto, Japan. Electronic 
      address: otamasao@shinshu-u.ac.jp.
FAU - Umemura, Takeji
AU  - Umemura T
AD  - Department of Medicine, Division of Gastroenterology and Hepatology, Shinshu 
      University School of Medicine, Matsumoto, Japan; Department of Health Promotion 
      Medicine, Shinshu University School of Medicine, Matsumoto, Japan; Department of 
      Advanced Endoscopic Therapy, Shinshu University School of Medicine, Matsumoto, 
      Japan; Consultation Center for Liver Diseases, Shinshu University Hospital, 
      Matsumoto, Japan.
LA  - eng
PT  - Journal Article
DEP - 20230602
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (Hepatitis B Surface Antigens)
RN  - 0 (HLA-G Antigens)
SB  - IM
MH  - Humans
MH  - *Carcinoma, Hepatocellular/genetics/virology
MH  - Case-Control Studies
MH  - East Asian People
MH  - Genetic Predisposition to Disease
MH  - *Hepatitis B/complications/genetics
MH  - Hepatitis B Surface Antigens
MH  - Hepatitis B virus
MH  - *HLA-G Antigens/genetics
MH  - *Liver Neoplasms/genetics/virology
MH  - Polymorphism, Single Nucleotide
OTO - NOTNLM
OT  - Hepatitis B
OT  - Human leukocyte antigen-G
OT  - Polymorphisms
COIS- Declaration of Competing Interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2023/06/05 00:42
MHDA- 2023/07/17 06:42
CRDT- 2023/06/04 21:58
PHST- 2023/02/13 00:00 [received]
PHST- 2023/04/24 00:00 [revised]
PHST- 2023/05/15 00:00 [accepted]
PHST- 2023/07/17 06:42 [medline]
PHST- 2023/06/05 00:42 [pubmed]
PHST- 2023/06/04 21:58 [entrez]
AID - S0198-8859(23)00071-X [pii]
AID - 10.1016/j.humimm.2023.05.002 [doi]
PST - ppublish
SO  - Hum Immunol. 2023 Aug;84(8):401-407. doi: 10.1016/j.humimm.2023.05.002. Epub 2023 
      Jun 2.