PMID- 37273040
OWN - NLM
STAT- MEDLINE
DCOM- 20240415
LR  - 20240417
IS  - 1573-4919 (Electronic)
IS  - 0300-8177 (Linking)
VI  - 479
IP  - 4
DP  - 2024 Apr
TI  - LncRNA LOXL1-AS1 promotes proliferation and invasion and inhibits apoptosis in 
      retinoblastoma by regulating the MAPK signaling pathway.
PG  - 1011-1022
LID - 10.1007/s11010-023-04774-4 [doi]
AB  - Retinoblastoma (RB) is an intraocular malignancy that is most common in children 
      and rare in adults. Addressing novel biomarkers and therapeutic targets for RB to 
      modulate tumor progression has become a challenge. The aim of the present study 
      was to investigate the function of long non-coding RNAs (LncRNAs) LOXL1-AS1 in RB 
      cell proliferation and metastasis. It was found that LOXL1-AS1 was overexpressed 
      in RB tissues and cells. In order to evaluate cell viability and colony formation 
      potential, the knockdown of LOXL1-AS1 has been established. Knockdown of 
      LOXL1-AS1 was also inhibited cells migration and invasion. In addition, the 
      proportion of cells in the G2/M phase of the sh-LOXL1-AS1 group increased 
      significantly, and the proportion of cells in the sh-NC group decreased 
      significantly. In the xenograft model of RB, the tumors in the sh-LOXL1-AS1 group 
      grow slowly compared to the sh-NC group. Western blot analysis revealed that 
      LOXL1-AS1 can regulate the progression of RB cells through MAPK signaling pathway 
      in vitro and in vivo. These results indicated that LncRNA LOXL1-AS1 promotes 
      proliferation, invasion and inhibits apoptosis of retinoblastoma by regulating 
      MAPK signaling pathway, and might be expected to be a novel basis for clinical 
      diagnosis and treatment.
CI  - (c) 2023. The Author(s), under exclusive licence to Springer Science+Business 
      Media, LLC, part of Springer Nature.
FAU - Wu, Weiqi
AU  - Wu W
AD  - Department of Ophthalmology, The Second Affiliated Hospital of Nanchang 
      University, 1# Minde Road, Nanchang, Jiangxi, 330006, People's Republic of China.
AD  - Medical Department of Graduate School, Jiangxi Research Institute of 
      Ophthalmology and Visual Sciences, Key Laboratory of Ophthalmology of Jiangxi 
      Province, Jiangxi Key Laboratory of Cancer Metastasis and Precision Treatment, 
      Nanchang University, Nanchang, 330006, Jiangxi, People's Republic of China.
FAU - Zhang, Yanyan
AU  - Zhang Y
AD  - Department of Ophthalmology, The Second Affiliated Hospital of Nanchang 
      University, 1# Minde Road, Nanchang, Jiangxi, 330006, People's Republic of China.
AD  - Medical Department of Graduate School, Jiangxi Research Institute of 
      Ophthalmology and Visual Sciences, Key Laboratory of Ophthalmology of Jiangxi 
      Province, Jiangxi Key Laboratory of Cancer Metastasis and Precision Treatment, 
      Nanchang University, Nanchang, 330006, Jiangxi, People's Republic of China.
FAU - Xu, Caixia
AU  - Xu C
AD  - Department of Ophthalmology, The Second Affiliated Hospital of Nanchang 
      University, 1# Minde Road, Nanchang, Jiangxi, 330006, People's Republic of China.
AD  - Medical Department of Graduate School, Jiangxi Research Institute of 
      Ophthalmology and Visual Sciences, Key Laboratory of Ophthalmology of Jiangxi 
      Province, Jiangxi Key Laboratory of Cancer Metastasis and Precision Treatment, 
      Nanchang University, Nanchang, 330006, Jiangxi, People's Republic of China.
FAU - Yang, Hongwei
AU  - Yang H
AD  - Department of Ophthalmology, The Second Affiliated Hospital of Nanchang 
      University, 1# Minde Road, Nanchang, Jiangxi, 330006, People's Republic of China.
AD  - Medical Department of Graduate School, Jiangxi Research Institute of 
      Ophthalmology and Visual Sciences, Key Laboratory of Ophthalmology of Jiangxi 
      Province, Jiangxi Key Laboratory of Cancer Metastasis and Precision Treatment, 
      Nanchang University, Nanchang, 330006, Jiangxi, People's Republic of China.
FAU - Liu, Siyi
AU  - Liu S
AD  - Department of Nephrology, The First Affiliated Hospital of Nanchang University, 
      Nanchang, 330006, Jiangxi, People's Republic of China.
FAU - Huang, Guofu
AU  - Huang G
AD  - Department of Ophthalmology, The Second Affiliated Hospital of Nanchang 
      University, 1# Minde Road, Nanchang, Jiangxi, 330006, People's Republic of China. 
      hgf2222@sina.com.
LA  - eng
GR  - 82060501/National Natural Science Foundation of China/
GR  - 20202ACB206005/Natural Science Foundation of Jiangxi Province/
PT  - Journal Article
DEP - 20230605
PL  - Netherlands
TA  - Mol Cell Biochem
JT  - Molecular and cellular biochemistry
JID - 0364456
RN  - EC 1.4.- (Amino Acid Oxidoreductases)
RN  - EC 1.4.3.- (LOXL1 protein, human)
RN  - 0 (RNA, Long Noncoding)
SB  - IM
MH  - Humans
MH  - Amino Acid Oxidoreductases/genetics/metabolism
MH  - Apoptosis/genetics
MH  - Cell Line, Tumor
MH  - Cell Movement/genetics
MH  - Cell Proliferation/genetics
MH  - Gene Expression Regulation, Neoplastic
MH  - *Retinal Neoplasms/genetics
MH  - *Retinoblastoma/genetics
MH  - *RNA, Long Noncoding/metabolism
MH  - Signal Transduction
OTO - NOTNLM
OT  - LncRNA LOXL1-AS1
OT  - MAPK pathway
OT  - Retinoblastoma
EDAT- 2023/06/05 13:04
MHDA- 2024/04/15 06:43
CRDT- 2023/06/05 11:08
PHST- 2023/02/24 00:00 [received]
PHST- 2023/05/18 00:00 [accepted]
PHST- 2024/04/15 06:43 [medline]
PHST- 2023/06/05 13:04 [pubmed]
PHST- 2023/06/05 11:08 [entrez]
AID - 10.1007/s11010-023-04774-4 [pii]
AID - 10.1007/s11010-023-04774-4 [doi]
PST - ppublish
SO  - Mol Cell Biochem. 2024 Apr;479(4):1011-1022. doi: 10.1007/s11010-023-04774-4. 
      Epub 2023 Jun 5.