PMID- 37273095
OWN - NLM
STAT- MEDLINE
DCOM- 20230721
LR  - 20230721
IS  - 1559-0291 (Electronic)
IS  - 0273-2289 (Linking)
VI  - 195
IP  - 8
DP  - 2023 Aug
TI  - Investigation of Paracetamol Entrapped Nanoporous Silica Nanoparticles in 
      Transdermal Drug Delivery System.
PG  - 4712-4727
LID - 10.1007/s12010-023-04576-w [doi]
AB  - An effort was made to administer paracetamol drug through transdermal patch, as 
      no such formulation of this drug has been developed yet. The primary cause for 
      the lack of such formulations is paracetamol's poor aqueous solubility. As a 
      result, the current research concentrated on preparing nanomedicines, or 
      drug-loaded nanoparticles, for delivery via transdermal formulations. 
      Nanoparticles can improve the solubility of weakly aqueous soluble or even 
      aqueous insoluble drugs by changing the crystalline structure of loaded medicines 
      to an amorphous state and serving as drug permeation boosters. Silica 
      nanoparticles (SNPs) were synthesized through sol-gel technique to achieve the 
      aforementioned goal. DLS data revealed that the average particle size was around 
      100-200 nm, which was sufficient to penetrate the skin barrier. XRD analysis 
      showed that the SNPs were amorphous, and the drug molecules lost their 
      crystallinity after encapsulation into the nanoparticles, causing the enhancement 
      of dissolution of drug molecules in physiological pH (pH-7.4). Different kinetic 
      models were employed for the ex vivo dissolution data to evaluate the suitable 
      kinetic model followed by the drug release in both burst and sustained phase. In 
      vivo analgesic study was executed on mice applying each of the transdermal 
      formulations to examine the performances of the patches.
CI  - (c) 2023. The Author(s), under exclusive licence to Springer Science+Business 
      Media, LLC, part of Springer Nature.
FAU - Adhikary, Sourav
AU  - Adhikary S
AUID- ORCID: 0000-0003-3936-826X
AD  - School of Materials Science and Nanotechnology, Jadavpur University, Kolkata, 
      India. SOURAVADHIKARY906@GMAIL.COM.
FAU - Al Hoque, Ashique
AU  - Al Hoque A
AD  - Department of Pharmaceutical Technology, Jadavpur University, Kolkata, India.
AD  - Department of Coatings and Polymeric Materials, North Dakota State University, 
      Fargo, ND, 58108, USA.
FAU - Ray, Manisheeta
AU  - Ray M
AD  - Department of Pharmaceutical Technology, Jadavpur University, Kolkata, India.
FAU - Paul, Swastik
AU  - Paul S
AD  - Department of Chemical Engineering, University of Calcutta, Kolkata, India.
FAU - Hossain, Akbar
AU  - Hossain A
AD  - Department of Chemistry, Jadavpur University, Kolkata, India.
FAU - Goswami, Subrata
AU  - Goswami S
AD  - Department of Labour, ESI Institute of Pain Management, Kolkata, India.
FAU - Dey, Rajib
AU  - Dey R
AD  - Metallurgical and Material Engineering Department, Jadavpur University, Kolkata, 
      India.
LA  - eng
GR  - ST/P/S&T/6G-32/2017/Department of Science and Technology, Government of West 
      Bengal/
PT  - Journal Article
DEP - 20230605
PL  - United States
TA  - Appl Biochem Biotechnol
JT  - Applied biochemistry and biotechnology
JID - 8208561
RN  - 362O9ITL9D (Acetaminophen)
RN  - 7631-86-9 (Silicon Dioxide)
SB  - IM
MH  - Mice
MH  - Animals
MH  - Skin/metabolism
MH  - Skin Absorption
MH  - Acetaminophen/metabolism
MH  - *Nanopores
MH  - Silicon Dioxide
MH  - Drug Delivery Systems
MH  - *Nanoparticles/chemistry
MH  - Drug Liberation
OTO - NOTNLM
OT  - Analgesic activity
OT  - Silica nanoparticles
OT  - Skin permeation
OT  - Sustained release
OT  - Transdermal patch
EDAT- 2023/06/05 13:04
MHDA- 2023/07/21 06:42
CRDT- 2023/06/05 11:10
PHST- 2023/05/24 00:00 [accepted]
PHST- 2023/07/21 06:42 [medline]
PHST- 2023/06/05 13:04 [pubmed]
PHST- 2023/06/05 11:10 [entrez]
AID - 10.1007/s12010-023-04576-w [pii]
AID - 10.1007/s12010-023-04576-w [doi]
PST - ppublish
SO  - Appl Biochem Biotechnol. 2023 Aug;195(8):4712-4727. doi: 
      10.1007/s12010-023-04576-w. Epub 2023 Jun 5.