PMID- 37273249
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230606
IS  - 1948-9358 (Print)
IS  - 1948-9358 (Electronic)
IS  - 1948-9358 (Linking)
VI  - 14
IP  - 5
DP  - 2023 May 15
TI  - Mechanism of immune attack in the progression of obesity-related type 2 diabetes.
PG  - 494-511
LID - 10.4239/wjd.v14.i5.494 [doi]
AB  - Obesity and overweight are widespread issues in adults, children, and adolescents 
      globally, and have caused a noticeable rise in obesity-related complications such 
      as type 2 diabetes mellitus (T2DM). Chronic low-grade inflammation is an 
      important promotor of the pathogenesis of obesity-related T2DM. This 
      proinflammatory activation occurs in multiple organs and tissues. Immune 
      cell-mediated systemic attack is considered to contribute strongly to impaired 
      insulin secretion, insulin resistance, and other metabolic disorders. This review 
      focused on highlighting recent advances and underlying mechanisms of immune cell 
      infiltration and inflammatory responses in the gut, islet, and insulin-targeting 
      organs (adipose tissue, liver, skeletal muscle) in obesity-related T2DM. There is 
      current evidence that both the innate and adaptive immune systems contribute to 
      the development of obesity and T2DM.
CI  - (c)The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights 
      reserved.
FAU - Wang, Hua-Wei
AU  - Wang HW
AD  - Department of Endocrinology, Zhongnan Hospital of Wuhan University, Wuhan 430071, 
      Hubei Province, China.
FAU - Tang, Jun
AU  - Tang J
AD  - Department of Endocrinology, Zhongnan Hospital of Wuhan University, Wuhan 430071, 
      Hubei Province, China.
FAU - Sun, Li
AU  - Sun L
AD  - Department of Endocrinology, Zhongnan Hospital of Wuhan University, Wuhan 430071, 
      Hubei Province, China.
FAU - Li, Zhen
AU  - Li Z
AD  - Department of Hepatobiliary and Pancreatic Surgery, Zhongnan Hospital of Wuhan 
      University, Wuhan 430071, Hubei Province, China.
FAU - Deng, Ming
AU  - Deng M
AD  - Department of Radiology, Zhongnan Hospital of Wuhan University, Wuhan 430071, 
      Hubei Province, China.
FAU - Dai, Zhe
AU  - Dai Z
AD  - Department of Endocrinology, Zhongnan Hospital of Wuhan University, Wuhan 430071, 
      Hubei Province, China. daizhe@znhospital.cn.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - World J Diabetes
JT  - World journal of diabetes
JID - 101547524
PMC - PMC10236992
OTO - NOTNLM
OT  - Immune cells
OT  - Inflammation
OT  - Insulin resistance
OT  - Obesity
OT  - Pathological mechanism
OT  - Type 2 diabetes mellitus
COIS- Conflict-of-interest statement: The authors have no conflicts of interest to 
      declare.
EDAT- 2023/06/05 13:04
MHDA- 2023/06/05 13:05
PMCR- 2023/05/15
CRDT- 2023/06/05 11:44
PHST- 2022/12/28 00:00 [received]
PHST- 2023/03/06 00:00 [revised]
PHST- 2023/03/30 00:00 [accepted]
PHST- 2023/06/05 13:05 [medline]
PHST- 2023/06/05 13:04 [pubmed]
PHST- 2023/06/05 11:44 [entrez]
PHST- 2023/05/15 00:00 [pmc-release]
AID - 10.4239/wjd.v14.i5.494 [doi]
PST - ppublish
SO  - World J Diabetes. 2023 May 15;14(5):494-511. doi: 10.4239/wjd.v14.i5.494.