PMID- 37273256
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230919
IS  - 1948-9358 (Print)
IS  - 1948-9358 (Electronic)
IS  - 1948-9358 (Linking)
VI  - 14
IP  - 5
DP  - 2023 May 15
TI  - Diabetes mellitus and atrial fibrillation-from pathophysiology to treatment.
PG  - 512-527
LID - 10.4239/wjd.v14.i5.512 [doi]
AB  - Type 2 diabetes mellitus (T2DM) is a leading risk factor for cardiovascular 
      complications around the globe and one of the most common medical conditions. 
      Atrial fibrillation (AF) is the most common supraventricular arrhythmia, with a 
      rapidly increasing prevalence. T2DM has been closely associated with the risk of 
      AF development, identified as an independent risk factor. Regarding 
      cardio-vascular complications, both AF and T2DM have been linked with high 
      mortality. The underlying pathophysiology has not been fully determined yet; 
      however, it is multifactorial, including structural, electrical, and autonomic 
      pathways. Novel therapies include pharmaceutical agents in sodium-glucose 
      cotransporter-2 inhibitors, as well as antiarrhythmic strategies, such as 
      cardioversion and ablation. Of interest, glucose-lowering therapies may affect 
      the prevalence of AF. This review presents the current evidence regarding the 
      connection between the two entities, the pathophysiological pathways that link 
      them, and the therapeutic options that exist.
CI  - (c)The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights 
      reserved.
FAU - Leopoulou, Marianna
AU  - Leopoulou M
AD  - 1 Cardiology Clinic, 'Hippokration' General Hospital, National and Kapodistrian 
      University of Athens, School of Medicine, Athens 11527, Greece.
FAU - Theofilis, Panagiotis
AU  - Theofilis P
AD  - 1 Cardiology Clinic, 'Hippokration' General Hospital, National and Kapodistrian 
      University of Athens, School of Medicine, Athens 11527, Greece.
FAU - Kordalis, Athanasios
AU  - Kordalis A
AD  - 1 Cardiology Clinic, 'Hippokration' General Hospital, National and Kapodistrian 
      University of Athens, School of Medicine, Athens 11527, Greece.
FAU - Papageorgiou, Nikolaos
AU  - Papageorgiou N
AD  - 1 Cardiology Clinic, 'Hippokration' General Hospital, National and Kapodistrian 
      University of Athens, School of Medicine, Athens 11527, Greece.
FAU - Sagris, Marios
AU  - Sagris M
AD  - 1 Cardiology Clinic, 'Hippokration' General Hospital, National and Kapodistrian 
      University of Athens, School of Medicine, Athens 11527, Greece.
FAU - Oikonomou, Evangelos
AU  - Oikonomou E
AD  - 3 Cardiology Clinic, 'Sotiria' Chest Diseases Hospital, National and Kapodistrian 
      University of Athens, School of Medicine, Athens 11527, Greece.
FAU - Tousoulis, Dimitris
AU  - Tousoulis D
AD  - 1 Cardiology Clinic, 'Hippokration' General Hospital, National and Kapodistrian 
      University of Athens, School of Medicine, Athens 11527, Greece. 
      drtousoulis@hotmail.com.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - World J Diabetes
JT  - World journal of diabetes
JID - 101547524
PMC - PMC10236990
OTO - NOTNLM
OT  - Atrial fibrillation
OT  - Diabetes mellitus
OT  - Pathophysiology
OT  - Treatment
COIS- Conflict-of-interest statement: All the authors report no relevant conflicts of 
      interest for this article.
EDAT- 2023/06/05 13:04
MHDA- 2023/06/05 13:05
PMCR- 2023/05/15
CRDT- 2023/06/05 11:44
PHST- 2023/01/20 00:00 [received]
PHST- 2023/02/21 00:00 [revised]
PHST- 2023/04/07 00:00 [accepted]
PHST- 2023/06/05 13:05 [medline]
PHST- 2023/06/05 13:04 [pubmed]
PHST- 2023/06/05 11:44 [entrez]
PHST- 2023/05/15 00:00 [pmc-release]
AID - 10.4239/wjd.v14.i5.512 [doi]
PST - ppublish
SO  - World J Diabetes. 2023 May 15;14(5):512-527. doi: 10.4239/wjd.v14.i5.512.