PMID- 37273292
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230606
IS  - 2168-8184 (Print)
IS  - 2168-8184 (Electronic)
IS  - 2168-8184 (Linking)
VI  - 15
IP  - 5
DP  - 2023 May
TI  - Immune Reconstitution Inflammatory Syndrome Reaction in Patient on Long-Term 
      Prednisone.
PG  - e38506
LID - 10.7759/cureus.38506 [doi]
LID - e38506
AB  - Immune reconstitution inflammatory syndrome (IRIS) can be triggered in many ways. 
      IRIS has been recognized during tuberculosis (TB) therapy, especially in patients 
      newly initiated on antiretroviral therapy for HIV or those taken off 
      immunosuppressives such as tumor necrosis factor-alpha inhibitors. However, there 
      are still many triggers of IRIS that are less understood. This case report 
      describes a patient with scrofula that was concerning for TB reactivation, who 
      then had subsequent IRIS. The patient had been consistently using low-dose 
      long-term prednisone for suppression of his polymyalgia rheumatica. It is 
      suspected that the IRIS reaction could be due to an interaction between rifampin 
      and prednisone causing decreased efficacy of its immunosuppressive effects.
CI  - Copyright (c) 2023, Sahgal et al.
FAU - Sahgal, Savina
AU  - Sahgal S
AD  - Medical School, Rush University Medical Center, Chicago, USA.
FAU - Shankaran, Shivanjali
AU  - Shankaran S
AD  - Infectious Diseases, Rush University Medical Center, Chicago, USA.
FAU - Ansell, David A
AU  - Ansell DA
AD  - Internal Medicine, Rush University Medical Center, Chicago, USA.
LA  - eng
PT  - Case Reports
DEP - 20230503
PL  - United States
TA  - Cureus
JT  - Cureus
JID - 101596737
PMC - PMC10238129
OTO - NOTNLM
OT  - autoimmune
OT  - corticosteroids
OT  - inflammatory reaction
OT  - iris
OT  - prednisone
OT  - tuberculosis
COIS- The authors have declared that no competing interests exist.
EDAT- 2023/06/05 13:05
MHDA- 2023/06/05 13:06
PMCR- 2023/05/03
CRDT- 2023/06/05 11:45
PHST- 2023/05/03 00:00 [accepted]
PHST- 2023/06/05 13:06 [medline]
PHST- 2023/06/05 13:05 [pubmed]
PHST- 2023/06/05 11:45 [entrez]
PHST- 2023/05/03 00:00 [pmc-release]
AID - 10.7759/cureus.38506 [doi]
PST - epublish
SO  - Cureus. 2023 May 3;15(5):e38506. doi: 10.7759/cureus.38506. eCollection 2023 May.