PMID- 37273680
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230606
IS  - 2168-8184 (Print)
IS  - 2168-8184 (Electronic)
IS  - 2168-8184 (Linking)
VI  - 15
IP  - 6
DP  - 2023 Jun
TI  - Novel Intracoronary Infusion of Supersaturated Oxygen Therapy in Patients 
      Presenting With Acute ST Elevation Myocardial Infarction: Does It Help?
PG  - e39915
LID - 10.7759/cureus.39915 [doi]
LID - e39915
AB  - Supersaturated oxygen (SSO(2)) is one of the emerging therapies that has shown 
      benefit for patients suffering from acute ST elevation myocardial infarction 
      (STEMI) in terms of reducing infarct size, which has been used as a prognostic 
      indicator for future heart failure and hospitalizations. Trials investigating 
      SSO(2) therapy have shown improvement in infarct size when used as an adjunct 
      therapy to percutaneous trans-luminal coronary angioplasty (PTCA) or percutaneous 
      coronary intervention (PCI) in patients presenting with acute myocardial 
      infarction (aMI).  Here we present a patient with a mid left anterior descending 
      artery (mLAD) STEMI who underwent SSO(2) therapy. The patient presented with new 
      onset angina and ST elevations on EKG. He underwent emergent coronary 
      angiography, which confirmed an mLAD complete vessel occlusion. Successful PCI 
      was done with a drug-eluting stent followed by supersaturated oxygen therapy. On 
      follow-up evaluation, the patient had improved left ventricular (LV) ejection 
      fraction from 35% to 60%. This case highlights the safety and efficacy of SSO(2) 
      therapy for patients suffering from acute anterior wall myocardial infarction. We 
      recommend further investigation of this therapy for its routine use, safety, and 
      prognostic utility. We also recommend routine use of adjunctive SSO(2) therapy 
      for patients suffering acute anterior STEMI.
CI  - Copyright (c) 2023, Alamzaib et al.
FAU - Alamzaib, Sardar M
AU  - Alamzaib SM
AD  - Cardiology, Marshall University Joan C. Edwards School of Medicine, Huntington, 
      USA.
FAU - Jensen, Jay C
AU  - Jensen JC
AD  - Internal Medicine, Marshall University Joan C. Edwards School of Medicine, 
      Huntington, USA.
FAU - Mansoor, Kanaan
AU  - Mansoor K
AD  - Internal Medicine, Marshall University Joan C. Edwards School of Medicine, 
      Huntington, USA.
FAU - Rabbani, Noor Ul Ann
AU  - Rabbani NUA
AD  - Internal Medicine, Marshall University Joan C. Edwards School of Medicine, 
      Huntington, USA.
FAU - Sayyed, Rameez
AU  - Sayyed R
AD  - Cardiology, Marshall University Joan C. Edwards School of Medicine, Huntington, 
      USA.
LA  - eng
PT  - Case Reports
DEP - 20230603
PL  - United States
TA  - Cureus
JT  - Cureus
JID - 101596737
PMC - PMC10239294
OTO - NOTNLM
OT  - acs ( acute coronary syndrome )
OT  - cardiac chest pain
OT  - early ptca (percutaneous transluminal coronary angioplasty)
OT  - echocardiogram (echo)
OT  - myocardial infarction  
OT  - primary percutaneous coronary intervention (pci)
OT  - st elevated myocardial infarction (stemi)
OT  - supersaturated oxygen therapy
COIS- The authors have declared that no competing interests exist.
EDAT- 2023/06/05 13:04
MHDA- 2023/06/05 13:05
PMCR- 2023/06/03
CRDT- 2023/06/05 11:49
PHST- 2023/06/03 00:00 [accepted]
PHST- 2023/06/05 13:05 [medline]
PHST- 2023/06/05 13:04 [pubmed]
PHST- 2023/06/05 11:49 [entrez]
PHST- 2023/06/03 00:00 [pmc-release]
AID - 10.7759/cureus.39915 [doi]
PST - epublish
SO  - Cureus. 2023 Jun 3;15(6):e39915. doi: 10.7759/cureus.39915. eCollection 2023 Jun.