PMID- 37273960
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230606
IS  - 1874-3064 (Print)
IS  - 1874-3064 (Electronic)
IS  - 1874-3064 (Linking)
VI  - 16
DP  - 2022
TI  - Impaired Cardiovascular Response to Exercise in Patients with Severe Asthma: A 
      Case-Control Study.
PG  - e187430642201170
LID - 10.2174/18743064-v16-e2201170 [doi]
LID - e187430642201170
AB  - BACKGROUND: Although asthmatics may present reduced exercise capacity, data on 
      their cardiovascular responses during exercise testing have been scarcely 
      investigated. The aim of this pilot case-control study is to test: a) whether 
      double product (DP), an index of cardiovascular reserve, differs among patients 
      with severe and mild-moderate asthma, and b) whether DP is associated with asthma 
      control level, physical activity (PA) and exercise capacity, in asthmatics 
      population. MATERIALS AND METHODS: A group of patients with severe asthma (group 
      S) and a matched group of patients with mild-moderate asthma (group M) was 
      studied. All participants completed asthma control and physical activity (IPAC) 
      questionnaires, lung function measurements and six-minute walk test. The exercise 
      capacity (as 6-minute walk distance (6MWD) and corresponding work), the Borg 
      Dyspnea, the rating of perceived excursion and the average PA METS were recorded. 
      RESULTS: A total of 18 patients were studied. DP at exercise end was 
      significantly lower in group S, compared to group M (16412.2+/-4732.1 vs. 
      18594.8+/-3984.4 mmHgXbpm; p=0.041) and was moderately associated with % predicted 
      6MWD (r=0.592; p=0.001). Group S patients were also presented with lower moderate 
      intensity PA, compared to group M, while exercise capacity was similar between 
      the groups. Asthma control level had no impact on exercise capacity nor PA 
      parameters. CONCLUSION: Patients with severe asthma may have impaired 
      cardiovascular reserve as established by DP, even when exercise capacity is 
      indifferent from patients with milder disease. As an easy-to-assess parameter, DP 
      may offer further information in the functional evaluation of these patients.
CI  - (c) 2022 Georgopoulou et al.
FAU - Georgopoulou, Athina
AU  - Georgopoulou A
AD  - Department of Respiratory Medicine, G. Papanikolaou Hospital, Thessaloniki, 
      Greece.
AD  - Postgraduate Course, Medical School and Department of Physical Education, 
      University of Thessaly, Larissa, Greece.
FAU - Fotiadou, Laskarina
AU  - Fotiadou L
AD  - Department of Respiratory Medicine, G. Papanikolaou Hospital, Thessaloniki, 
      Greece.
FAU - Tryfon, Stavros
AU  - Tryfon S
AD  - Department of Respiratory Medicine, G. Papanikolaou Hospital, Thessaloniki, 
      Greece.
FAU - Daniil, Zoi
AU  - Daniil Z
AD  - Postgraduate Course, Medical School and Department of Physical Education, 
      University of Thessaly, Larissa, Greece.
AD  - Department of Respiratory Medicine, Medical School, University of Thessaly, 
      Larissa, Greece.
FAU - Boutou, Afroditi K
AU  - Boutou AK
AD  - Department of Respiratory Medicine, G. Papanikolaou Hospital, Thessaloniki, 
      Greece.
AD  - Postgraduate Course, Medical School and Department of Physical Education, 
      University of Thessaly, Larissa, Greece.
LA  - eng
PT  - Journal Article
DEP - 20220315
PL  - United Arab Emirates
TA  - Open Respir Med J
JT  - The open respiratory medicine journal
JID - 101480481
PMC - PMC10158080
OTO - NOTNLM
OT  - Asthma
OT  - Cardiovascular reserve
OT  - Double product
OT  - Exercise capacity
OT  - Lung function
OT  - Physical activity
COIS- The authors declare no conflict of interest, financial or otherwise.
EDAT- 2022/03/15 00:00
MHDA- 2022/03/15 00:01
PMCR- 2022/01/01
CRDT- 2023/06/05 11:54
PHST- 2021/04/27 00:00 [received]
PHST- 2021/09/15 00:00 [revised]
PHST- 2021/12/24 00:00 [accepted]
PHST- 2022/03/15 00:01 [medline]
PHST- 2022/03/15 00:00 [pubmed]
PHST- 2023/06/05 11:54 [entrez]
PHST- 2022/01/01 00:00 [pmc-release]
AID - TORMJ-16-e187430642201170 [pii]
AID - 10.2174/18743064-v16-e2201170 [doi]
PST - epublish
SO  - Open Respir Med J. 2022 Mar 15;16:e187430642201170. doi: 
      10.2174/18743064-v16-e2201170. eCollection 2022.