PMID- 37274214
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230606
IS  - 1662-4548 (Print)
IS  - 1662-453X (Electronic)
IS  - 1662-453X (Linking)
VI  - 17
DP  - 2023
TI  - Cortical depth-dependent human fMRI of resting-state networks using EPIK.
PG  - 1151544
LID - 10.3389/fnins.2023.1151544 [doi]
LID - 1151544
AB  - INTRODUCTION: Recent laminar-fMRI studies have substantially improved 
      understanding of the evoked cortical responses in multiple sub-systems; in 
      contrast, the laminar component of resting-state networks spread over the whole 
      brain has been less studied due to technical limitations. Animal research 
      strongly suggests that the supragranular layers of the cortex play a critical 
      role in maintaining communication within the default mode network (DMN); however, 
      whether this is true in this and other human cortical networks remains unclear. 
      METHODS: Here, we used EPIK, which offers unprecedented coverage at 
      sub-millimeter resolution, to investigate cortical broad resting-state dynamics 
      with depth specificity in healthy volunteers. RESULTS: Our results suggest that 
      human DMN connectivity is primarily supported by intermediate and superficial 
      layers of the cortex, and furthermore, the preferred cortical depth used for 
      communication can vary from one network to another. In addition, the laminar 
      connectivity profile of some networks showed a tendency to change upon engagement 
      in a motor task. In line with these connectivity changes, we observed that the 
      amplitude of the low-frequency-fluctuations (ALFF), as well as the regional 
      homogeneity (ReHo), exhibited a different laminar slope when subjects were either 
      performing a task or were in a resting state (less variation among laminae, i.e., 
      lower slope, during task performance compared to rest). DISCUSSION: The 
      identification of varied laminar profiles concerning network connectivity, ALFF, 
      and ReHo, observed across two brain states (task vs. rest) has major implications 
      for the characterization of network-related diseases and suggests the potential 
      diagnostic value of laminar fMRI in psychiatric disorders, e.g., to differentiate 
      the cortical dynamics associated with disease stages linked, or not linked, to 
      behavioral changes. The evaluation of laminar-fMRI across the brain encompasses 
      computational challenges; nonetheless, it enables the investigation of a new 
      dimension of the human neocortex, which may be key to understanding neurological 
      disorders from a novel perspective.
CI  - Copyright (c) 2023 Pais-Roldan, Yun, Palomero-Gallagher and Shah.
FAU - Pais-Roldan, Patricia
AU  - Pais-Roldan P
AD  - Institute of Neuroscience and Medicine 4, Medical Imaging Physics, 
      Forschungszentrum Julich, Julich, Germany.
FAU - Yun, Seong Dae
AU  - Yun SD
AD  - Institute of Neuroscience and Medicine 4, Medical Imaging Physics, 
      Forschungszentrum Julich, Julich, Germany.
FAU - Palomero-Gallagher, Nicola
AU  - Palomero-Gallagher N
AD  - Institute of Neuroscience and Medicine 1, Structural and Functional Organisation 
      of the Brain, Forschungszentrum Julich, Julich, Germany.
AD  - C. and O. Vogt Institute for Brain Research, Heinrich-Heine-University, 
      Dusseldorf, Germany.
AD  - Department of Psychiatry, Psychotherapy and Psychosomatics, Medical Faculty, RWTH 
      Aachen, Aachen, Germany.
FAU - Shah, N Jon
AU  - Shah NJ
AD  - Institute of Neuroscience and Medicine 4, Medical Imaging Physics, 
      Forschungszentrum Julich, Julich, Germany.
AD  - Institute of Neuroscience and Medicine 11, Molecular Neuroscience and 
      Neuroimaging, JARA, Forschungszentrum Julich, Julich, Germany.
AD  - JARA-BRAIN-Translational Medicine, Aachen, Germany.
AD  - Department of Neurology, RWTH Aachen University, Aachen, Germany.
LA  - eng
PT  - Journal Article
DEP - 20230518
PL  - Switzerland
TA  - Front Neurosci
JT  - Frontiers in neuroscience
JID - 101478481
PMC - PMC10232833
OTO - NOTNLM
OT  - EPIK
OT  - cerebral cortex
OT  - cortical layer
OT  - high-resolution
OT  - resting-state fMRI
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2023/06/05 13:05
MHDA- 2023/06/05 13:06
PMCR- 2023/01/01
CRDT- 2023/06/05 11:59
PHST- 2023/01/26 00:00 [received]
PHST- 2023/04/26 00:00 [accepted]
PHST- 2023/06/05 13:06 [medline]
PHST- 2023/06/05 13:05 [pubmed]
PHST- 2023/06/05 11:59 [entrez]
PHST- 2023/01/01 00:00 [pmc-release]
AID - 10.3389/fnins.2023.1151544 [doi]
PST - epublish
SO  - Front Neurosci. 2023 May 18;17:1151544. doi: 10.3389/fnins.2023.1151544. 
      eCollection 2023.