PMID- 37274647
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230606
IS  - 2405-8440 (Print)
IS  - 2405-8440 (Electronic)
IS  - 2405-8440 (Linking)
VI  - 9
IP  - 6
DP  - 2023 Jun
TI  - Homocysteine levels, H-Hypertension, and the MTHFR C677T genotypes: A complex 
      interaction.
PG  - e16444
LID - 10.1016/j.heliyon.2023.e16444 [doi]
LID - e16444
AB  - BACKGROUND AND OBJECTIVES: High homocysteine levels are associated with increased 
      risk of hypertension and stroke. Homocysteine is metabolized by the 
      methylenetetrahydrofolate reductase (MTHFR). We aimed to investigate the levels 
      of homocysteine and their association with hypertension, stroke, and 
      antihypertensive medication usage in patients with different MTHFR C677T 
      genotypes. METHODS AND RESULTS: Genotype frequency of MTHFR polymorphism was 
      performed, and plasma homocysteine levels were measured in 2,640 adult Lebanese 
      patients. Hypertension, history of stroke, and list of medications were 
      documented, among other clinical and demographic parameters. The TT mutant 
      genotype and the T mutant allele of MTHFR were more prevalent in 
      hyperhomocysteinemia (HHcy) and H-hypertensive (H-HTN, defined as hypertension 
      with hyperhomocysteinemia) patients when compared to non-HHcy subjects and non 
      H-HTN patients respectively. Homocysteine levels were significantly higher in 
      hypertensive patients specifically among those on diuretics. A higher level of 
      homocysteine was found in hypertensive patients with the MTHFR T allele compared 
      to patients carrying the C allele. Among the T allele carriers, the average 
      plasma homocysteine level was 13.3 +/- 0.193 mumol/L for hypertensive subjects 
      compared to 11.9 +/- 0.173 mumol/L (non-hypertensives). Furthermore, homocysteine 
      levels significantly correlated with stroke risk in patients with the T alleles. 
      CONCLUSIONS: We found an association of homocysteine with hypertension, 
      hypertensive medication, and stroke risk among patients with the MTHFR T allele 
      and the TT genotype. The association of diuretics therapy with higher 
      homocysteine levels calls for routine measurements and therapeutic control of 
      homocysteine in patients on diuretic, to improve health-related outcomes.
CI  - (c) 2023 The Authors.
FAU - Al Hageh, Cynthia
AU  - Al Hageh C
AD  - College of Medicine and Health Sciences, Khalifa University of Science and 
      Technology, Abu Dhabi, United Arab Emirates.
FAU - Alefishat, Eman
AU  - Alefishat E
AD  - College of Medicine and Health Sciences, Khalifa University of Science and 
      Technology, Abu Dhabi, United Arab Emirates.
AD  - Department Biopharmaceutics and Clinical Pharmacy, Faculty of Pharmacy, The 
      University of Jordan, Amman 11942, Jordan.
AD  - Center for Biotechnology, Khalifa University, Abu Dhabi 127788, United Arab 
      Emirates.
FAU - Ghassibe-Sabbagh, Michella
AU  - Ghassibe-Sabbagh M
AD  - School of Arts and Sciences, Lebanese American University, Beirut, Lebanon.
FAU - Platt, Daniel E
AU  - Platt DE
AD  - Computational Biology Center, IBM TJ Watson Research Centre, Yorktown Hgts, NY, 
      USA.
FAU - Hamdan, Hamdan
AU  - Hamdan H
AD  - College of Medicine and Health Sciences, Khalifa University of Science and 
      Technology, Abu Dhabi, United Arab Emirates.
FAU - Tcheroyan, Raya
AU  - Tcheroyan R
AD  - School of Medicine, American University of Beirut, Beirut, Lebanon.
FAU - Chammas, Elie
AU  - Chammas E
AD  - School of Medicine, Lebanese University, Beirut, Lebanon.
FAU - O'Sullivan, Siobhan
AU  - O'Sullivan S
AD  - College of Medicine and Health Sciences, Khalifa University of Science and 
      Technology, Abu Dhabi, United Arab Emirates.
FAU - Abchee, Antoine
AU  - Abchee A
AD  - Sheikh Shakhbout Medical City, Abu Dhabi, United Arab Emirates.
FAU - Wang, Binyan
AU  - Wang B
AD  - Shenzhen Evergreen Medical Institute, Shenzhen, China.
FAU - Xu, Xiping
AU  - Xu X
AD  - Key Laboratory of Precision Nutrition and Food Quality, Ministry of Education, 
      Department of Nutrition and Health, College of Food Sciences and Nutritional 
      Engineering, China Agricultural University, Beijing, China.
FAU - Nader, Moni
AU  - Nader M
AD  - College of Medicine and Health Sciences, Khalifa University of Science and 
      Technology, Abu Dhabi, United Arab Emirates.
AD  - Center for Biotechnology, Khalifa University, Abu Dhabi 127788, United Arab 
      Emirates.
FAU - Zalloua, Pierre
AU  - Zalloua P
AD  - College of Medicine and Health Sciences, Khalifa University of Science and 
      Technology, Abu Dhabi, United Arab Emirates.
AD  - Center for Biotechnology, Khalifa University, Abu Dhabi 127788, United Arab 
      Emirates.
AD  - Harvard T.H. Chan School of Public Health, Boston, MA, USA.
LA  - eng
PT  - Journal Article
DEP - 20230523
PL  - England
TA  - Heliyon
JT  - Heliyon
JID - 101672560
PMC - PMC10238895
OTO - NOTNLM
OT  - C677T
OT  - Diuretics
OT  - H-hypertension
OT  - HHcy
OT  - MTHFR
OT  - rs1801133
COIS- The authors declare that they have no known competing financial interests or 
      personal relationships that could have appeared to influence the work reported in 
      this paper.
EDAT- 2023/06/05 13:04
MHDA- 2023/06/05 13:05
PMCR- 2023/05/23
CRDT- 2023/06/05 12:05
PHST- 2022/08/03 00:00 [received]
PHST- 2023/04/11 00:00 [revised]
PHST- 2023/05/16 00:00 [accepted]
PHST- 2023/06/05 13:05 [medline]
PHST- 2023/06/05 13:04 [pubmed]
PHST- 2023/06/05 12:05 [entrez]
PHST- 2023/05/23 00:00 [pmc-release]
AID - S2405-8440(23)03651-4 [pii]
AID - e16444 [pii]
AID - 10.1016/j.heliyon.2023.e16444 [doi]
PST - epublish
SO  - Heliyon. 2023 May 23;9(6):e16444. doi: 10.1016/j.heliyon.2023.e16444. eCollection 
      2023 Jun.