PMID- 37276891
OWN - NLM
STAT- MEDLINE
DCOM- 20230731
LR  - 20230731
IS  - 1873-4847 (Electronic)
IS  - 0955-2863 (Linking)
VI  - 119
DP  - 2023 Sep
TI  - Low glycemic index potato biscuits alleviate physio-histological damage and gut 
      dysbiosis in rats with type-2 diabetes mellitus induced by high-sugar and 
      high-fat diet and streptozotocin.
PG  - 109401
LID - S0955-2863(23)00134-1 [pii]
LID - 10.1016/j.jnutbio.2023.109401 [doi]
AB  - Type 2 diabetes mellitus (T2DM) is the most common type of diabetes globally and 
      poses a major concern for human health. This study aimed to investigate the 
      effects on T2DM of low-glycemic index (GI) potato biscuits with oat bran and 
      inulin as functional additives. T2DM was induced in rats by streptozotocin (STZ) 
      and a high-sugar and high-fat diet. The alleviation of T2DM by low-GI potato 
      biscuits at different doses was evaluated based on the analysis of glycolipid 
      levels, histological observations, inflammatory markers, and gut microbiota 
      structure. Compared to wheat biscuits, low-GI potato biscuits resulted in lower 
      postprandial blood glucose levels. After 8 weeks of intervention, fasting blood 
      sugar levels were 16.9% lower in T2DM rats fed high-dose low-GI potato biscuits 
      than in untreated T2DM rats. Moreover, the intervention with low-GI potato 
      biscuits significantly alleviated T2DM-induced pathological damage, glucose and 
      lipid metabolic disorders, and inflammation by reversing the levels of total 
      cholesterol, triglycerides, high-density lipoprotein cholesterol, low-density 
      lipoprotein cholesterol, transforming growth factor-beta, interleukin-1beta, 
      interleukin-6 and tumor necrosis factor-alpha. Moreover, the levels of short-chain 
      fatty acids and gut microbiota structure in T2DM rats were significantly 
      reversed. The abundance of beneficial bacteria (e.g., Bifidobacterium, 
      Lachnoclostridium, Roseburia) in the gut of T2DM rats was significantly increased 
      whereas the abundance of Escherichia-Shigella and Desulfovibrio decreased. The 
      present study revealed that low-GI potato biscuits alleviated damages caused by 
      high-sugar and high-fat diet- and STZ-induced T2DM in rats, as well as reversed 
      disturbances in the gut microbiota. Thus, low-GI potato biscuits are potentially 
      beneficial to T2DM patients.
CI  - Copyright (c) 2023 Elsevier Inc. All rights reserved.
FAU - Zhao, Renjie
AU  - Zhao R
AD  - Institute of Food Science and Technology, Chinese Academy of Agricultural 
      Sciences, Comprehensive Key Laboratory of Agro-Products Processing, Ministry of 
      Agriculture and Rural Affairs, Beijing, P.R. China.
FAU - Li, Nan
AU  - Li N
AD  - Institute of Food Science and Technology, Chinese Academy of Agricultural 
      Sciences, Comprehensive Key Laboratory of Agro-Products Processing, Ministry of 
      Agriculture and Rural Affairs, Beijing, P.R. China.
FAU - Liu, Wei
AU  - Liu W
AD  - Institute of Food Science and Technology, Chinese Academy of Agricultural 
      Sciences, Comprehensive Key Laboratory of Agro-Products Processing, Ministry of 
      Agriculture and Rural Affairs, Beijing, P.R. China.
FAU - Liu, Qiannan
AU  - Liu Q
AD  - Institute of Food Science and Technology, Chinese Academy of Agricultural 
      Sciences, Comprehensive Key Laboratory of Agro-Products Processing, Ministry of 
      Agriculture and Rural Affairs, Beijing, P.R. China.
FAU - Zhang, Liang
AU  - Zhang L
AD  - Institute of Food Science and Technology, Chinese Academy of Agricultural 
      Sciences, Comprehensive Key Laboratory of Agro-Products Processing, Ministry of 
      Agriculture and Rural Affairs, Beijing, P.R. China.
FAU - Peng, Xingyun
AU  - Peng X
AD  - College of Food Science and Nutritional Engineering, China Agricultural 
      University, Beijing, P.R. China.
FAU - Zhao, Ruixuan
AU  - Zhao R
AD  - Institute of Food Science and Technology, Chinese Academy of Agricultural 
      Sciences, Comprehensive Key Laboratory of Agro-Products Processing, Ministry of 
      Agriculture and Rural Affairs, Beijing, P.R. China. Electronic address: 
      zhaoruixuan@caas.com.
FAU - Hu, Honghai
AU  - Hu H
AD  - Institute of Food Science and Technology, Chinese Academy of Agricultural 
      Sciences, Comprehensive Key Laboratory of Agro-Products Processing, Ministry of 
      Agriculture and Rural Affairs, Beijing, P.R. China. Electronic address: 
      huhonghai@caas.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20230603
PL  - United States
TA  - J Nutr Biochem
JT  - The Journal of nutritional biochemistry
JID - 9010081
RN  - 5W494URQ81 (Streptozocin)
RN  - 0 (Cholesterol, HDL)
RN  - 0 (Blood Glucose)
SB  - IM
MH  - Humans
MH  - Rats
MH  - Animals
MH  - *Diabetes Mellitus, Type 2/metabolism
MH  - Glycemic Index
MH  - Streptozocin/adverse effects
MH  - *Solanum tuberosum/metabolism
MH  - Diet, High-Fat/adverse effects
MH  - Dysbiosis
MH  - Cholesterol, HDL
MH  - Blood Glucose/metabolism
OTO - NOTNLM
OT  - Gut microbiota
OT  - Inulin
OT  - Low-glycemic index
OT  - Oat bran
OT  - Potato biscuits
OT  - Type 2 diabetes
COIS- Declaration of Competing Interests The authors declare that there is no conflicts 
      of interest.
EDAT- 2023/06/06 01:11
MHDA- 2023/07/31 06:42
CRDT- 2023/06/05 19:20
PHST- 2022/12/19 00:00 [received]
PHST- 2023/05/25 00:00 [revised]
PHST- 2023/05/31 00:00 [accepted]
PHST- 2023/07/31 06:42 [medline]
PHST- 2023/06/06 01:11 [pubmed]
PHST- 2023/06/05 19:20 [entrez]
AID - S0955-2863(23)00134-1 [pii]
AID - 10.1016/j.jnutbio.2023.109401 [doi]
PST - ppublish
SO  - J Nutr Biochem. 2023 Sep;119:109401. doi: 10.1016/j.jnutbio.2023.109401. Epub 
      2023 Jun 3.