PMID- 37276941
OWN - NLM
STAT- MEDLINE
DCOM- 20231023
LR  - 20231027
IS  - 1539-7262 (Electronic)
IS  - 0022-2275 (Print)
IS  - 0022-2275 (Linking)
VI  - 64
IP  - 7
DP  - 2023 Jul
TI  - Lipoprotein(a), family history of cardiovascular disease, and incidence of heart 
      failure.
PG  - 100398
LID - S0022-2275(23)00071-8 [pii]
LID - 10.1016/j.jlr.2023.100398 [doi]
LID - 100398
AB  - Lipoprotein(a) (Lp(a)) is a largely genetically determined biomarker for 
      cardiovascular disease (CVD), while its potential interplay with family history 
      (FHx) of CVD, a measure of both genetic and environmental exposures, remains 
      unclear. We examined the associations of Lp(a) in terms of circulating 
      concentration or polygenetic risk score (PRS), and FHx of CVD with risk of 
      incident heart failure (HF). Included were 299,158 adults from the UK Biobank 
      without known HF and CVD at baseline. Hazards ratios (HRs) and 95% Cls were 
      estimated by Cox regression models adjusted for traditional risk factors defined 
      by the Atherosclerosis Risk in Communities study HF risk score. During the 
      11.8-year follow-up, 5,502 incidents of HF occurred. Higher levels of circulating 
      Lp(a), Lp(a) PRS, and positive FHx of CVD were associated with higher risks of 
      HF. Compared with individuals who had lower circulating Lp(a) and no FHx, HRs 
      (95% CIs) of HF were 1.36 (1.25, 1.49), 1.31 (1.19, 1.43), and 1.42 (1.22, 1.67) 
      for those with higher Lp(a) and a positive history of CVD for all family members, 
      parents, and siblings, respectively; similar results were observed by using Lp(a) 
      PRS. The risk estimates for HF associated with elevated Lp(a) and positive FHx 
      were attenuated after excluding those with incident myocardial infarction (MI) 
      during follow-up. Lp(a) and FHx of CVD were independent risk factors for incident 
      HF, and the highest risk of HF was observed among individuals with both risk 
      factors. The association may be partly mediated by myocardial infarction.
CI  - Copyright (c) 2023 The Authors. Published by Elsevier Inc. All rights reserved.
FAU - Wang, Hai-Peng
AU  - Wang HP
AD  - Department of Cardiology, The First Affiliated Hospital of Soochow University, 
      Suzhou, China.
FAU - Zhang, Na
AU  - Zhang N
AD  - School of Public Health, Shanghai Jiao Tong University School of Medicine, 
      Shanghai, China.
FAU - Liu, Yu-Jie
AU  - Liu YJ
AD  - Department of Nutrition and Food Hygiene, School of Public Health, Suzhou Medical 
      College of Soochow University, Suzhou, China.
FAU - Xia, Tian-Long
AU  - Xia TL
AD  - Division of Public Health Emergency, Shenzhen Center for Disease Control and 
      Prevention, Shenzhen, Guangdong, China.
FAU - Chen, Guo-Chong
AU  - Chen GC
AD  - Department of Nutrition and Food Hygiene, School of Public Health, Suzhou Medical 
      College of Soochow University, Suzhou, China.
FAU - Yang, Jing
AU  - Yang J
AD  - Department of Nutrition and Food Hygiene, School of Public Health, Suzhou Medical 
      College of Soochow University, Suzhou, China; Department of Clinical Nutrition, 
      The First Affiliated Hospital of Soochow University, Suzhou, China. Electronic 
      address: cristina83@163.com.
FAU - Li, Fu-Rong
AU  - Li FR
AD  - Shenzhen Key Laboratory of Cardiovascular Health and Precision Medicine, Southern 
      University of Science and Technology, Shenzhen, China; School of Public Health 
      and Emergency Management, Southern University of Science and Technology, 
      Shenzhen, China; Department of Epidemiology, School of Public Health, Southern 
      Medical University, Guangzhou, China. Electronic address: lifr@sustech.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20230603
PL  - United States
TA  - J Lipid Res
JT  - Journal of lipid research
JID - 0376606
RN  - 0 (Lipoprotein(a))
SB  - IM
MH  - Adult
MH  - Humans
MH  - *Cardiovascular Diseases/epidemiology/genetics
MH  - Incidence
MH  - Lipoprotein(a)/genetics
MH  - *Heart Failure/epidemiology/genetics/complications
MH  - *Myocardial Infarction/epidemiology/genetics
MH  - Risk Factors
PMC - PMC10339055
OTO - NOTNLM
OT  - Lipoprotein(a)
OT  - family history of cardiovascular disease
OT  - heart failure
COIS- Conflict of interest The authors declare that they have no known competing 
      financial interests or personal relationships that could have appeared to 
      influence the work reported in this paper.
EDAT- 2023/06/06 01:11
MHDA- 2023/10/23 00:44
PMCR- 2023/06/03
CRDT- 2023/06/05 19:21
PHST- 2023/03/28 00:00 [received]
PHST- 2023/05/26 00:00 [revised]
PHST- 2023/05/27 00:00 [accepted]
PHST- 2023/10/23 00:44 [medline]
PHST- 2023/06/06 01:11 [pubmed]
PHST- 2023/06/05 19:21 [entrez]
PHST- 2023/06/03 00:00 [pmc-release]
AID - S0022-2275(23)00071-8 [pii]
AID - 100398 [pii]
AID - 10.1016/j.jlr.2023.100398 [doi]
PST - ppublish
SO  - J Lipid Res. 2023 Jul;64(7):100398. doi: 10.1016/j.jlr.2023.100398. Epub 2023 Jun 
      3.