PMID- 37276980
OWN - NLM
STAT- MEDLINE
DCOM- 20230807
LR  - 20230807
IS  - 1872-8227 (Electronic)
IS  - 0168-8227 (Linking)
VI  - 202
DP  - 2023 Aug
TI  - Impact of SGLT2-inhibitors on contrast-induced acute kidney injury in diabetic 
      patients with acute myocardial infarction with and without chronic kidney 
      disease: Insight from SGLT2-I AMI PROTECT registry.
PG  - 110766
LID - S0168-8227(23)00529-6 [pii]
LID - 10.1016/j.diabres.2023.110766 [doi]
AB  - AIMS: To analyze the association between chronic SGLT2-I treatment and 
      development of contrast-induced acute kidney injury (CI-AKI) in diabetic patients 
      with acute myocardial infarction (AMI) undergoing PCI. METHODS: Multicenter 
      international registry of consecutive patients with type 2 diabetes mellitus 
      (T2DM) and AMI undergoing PCI between 2018 and 2021. The study population was 
      stratified by the presence of chronic kidney disease (CKD) and anti-diabetic 
      therapy at admission (SGLT2-I versus non-SGLT2-I users). RESULTS: The study 
      population consisted of 646 patients: 111 SGLT2-I users [28 (25.2%) with CKD] and 
      535 non-SGLT2-I users [221 (41.3%) with CKD]. The median age was 70 [61-79] 
      years. SGLT2-I users exhibited significantly lower creatinine values at 72 h 
      after PCI, both in the non-CKD and CKD stratum. The overall rate of CI-AKI was 76 
      (11.8%), significantly lower in SGLT2-I users compared to non-SGLT2-I patients 
      (5.4% vs 13.1%, p = 0.022). This finding was also confirmed in patients without 
      CKD (p = 0.040). In the CKD cohort, SGLT2-I users maintained significantly lower 
      creatinine values at discharge. The use of SGLT2-I was an independent predictor 
      of reduced rate of CI-AKI (OR 0.356; 95%CI 0.134-0.943, p = 0.038). CONCLUSION: 
      In T2DM patients with AMI, the use of SGLT2-I was associated with a lower risk of 
      CI-AKI, mostly in patients without CKD.
CI  - Copyright (c) 2023 Elsevier B.V. All rights reserved.
FAU - Paolisso, Pasquale
AU  - Paolisso P
AD  - Cardiovascular Center Aalst, OLV-Clinic, Aalst, Belgium; Dept. of Advanced 
      Biomedical Sciences, University Federico II, Naples, Italy.
FAU - Bergamaschi, Luca
AU  - Bergamaschi L
AD  - Cardiology Unit, Cardiac Thoracic and Vascular Department, IRCCS Azienda 
      Ospedaliera-Universitaria di Bologna, Department of Medical and Surgical Sciences 
      - DIMEC, Alma Mater Studiorum, University of Bologna, Italy.
FAU - Cesaro, Arturo
AU  - Cesaro A
AD  - Department of Translational Medical Sciences, University of Campania 'Luigi 
      Vanvitelli', Naples, Italy; Division of Cardiology, A.O.R.N. "Sant'Anna e San 
      Sebastiano", Caserta, Italy.
FAU - Gallinoro, Emanuele
AU  - Gallinoro E
AD  - Clinical Cardiology and Cardiovascular Imaging Unit, Galeazzi-Sant'Ambrogio 
      Hospital, IRCCS, Milan, Italy, Department of Biomedical and Clinical Sciences, 
      University of Milan, Italy.
FAU - Gragnano, Felice
AU  - Gragnano F
AD  - Department of Translational Medical Sciences, University of Campania 'Luigi 
      Vanvitelli', Naples, Italy; Division of Cardiology, A.O.R.N. "Sant'Anna e San 
      Sebastiano", Caserta, Italy.
FAU - Sardu, Celestino
AU  - Sardu C
AD  - Department of Advanced Medical and Surgical Sciences, University of Campania 
      "Luigi Vanvitelli", Naples, Italy.
FAU - Mileva, Niya
AU  - Mileva N
AD  - Medical University of Sofia, Sofia, Bulgaria.
FAU - Foa, Alberto
AU  - Foa A
AD  - Cardiology Unit, Cardiac Thoracic and Vascular Department, IRCCS Azienda 
      Ospedaliera-Universitaria di Bologna, Department of Medical and Surgical Sciences 
      - DIMEC, Alma Mater Studiorum, University of Bologna, Italy.
FAU - Armillotta, Matteo
AU  - Armillotta M
AD  - Cardiology Unit, Cardiac Thoracic and Vascular Department, IRCCS Azienda 
      Ospedaliera-Universitaria di Bologna, Department of Medical and Surgical Sciences 
      - DIMEC, Alma Mater Studiorum, University of Bologna, Italy.
FAU - Sansonetti, Angelo
AU  - Sansonetti A
AD  - Cardiology Unit, Cardiac Thoracic and Vascular Department, IRCCS Azienda 
      Ospedaliera-Universitaria di Bologna, Department of Medical and Surgical Sciences 
      - DIMEC, Alma Mater Studiorum, University of Bologna, Italy.
FAU - Amicone, Sara
AU  - Amicone S
AD  - Cardiology Unit, Cardiac Thoracic and Vascular Department, IRCCS Azienda 
      Ospedaliera-Universitaria di Bologna, Department of Medical and Surgical Sciences 
      - DIMEC, Alma Mater Studiorum, University of Bologna, Italy.
FAU - Impellizzeri, Andrea
AU  - Impellizzeri A
AD  - Cardiology Unit, Cardiac Thoracic and Vascular Department, IRCCS Azienda 
      Ospedaliera-Universitaria di Bologna, Department of Medical and Surgical Sciences 
      - DIMEC, Alma Mater Studiorum, University of Bologna, Italy.
FAU - Belmonte, Marta
AU  - Belmonte M
AD  - Cardiovascular Center Aalst, OLV-Clinic, Aalst, Belgium; Dept. of Advanced 
      Biomedical Sciences, University Federico II, Naples, Italy.
FAU - Esposito, Giuseppe
AU  - Esposito G
AD  - Dept. of Advanced Biomedical Sciences, University Federico II, Naples, Italy; 
      Interventional Cardiology Unit, De Gasperis Cardio Center, Niguarda Hospital, 
      Milan, Italy.
FAU - Morici, Nuccia
AU  - Morici N
AD  - IRCCS S. Maria Nascente - Fondazione Don Carlo Gnocchi ONLUS, Milan, Italy.
FAU - Andrea Oreglia, Jacopo
AU  - Andrea Oreglia J
AD  - Interventional Cardiology Unit, De Gasperis Cardio Center, Niguarda Hospital, 
      Milan, Italy.
FAU - Casella, Gianni
AU  - Casella G
AD  - Unit of Cardiology, Maggiore Hospital, Bologna, Italy.
FAU - Mauro, Ciro
AU  - Mauro C
AD  - Department of Cardiology, Hospital Cardarelli, Naples, Italy.
FAU - Vassilev, Dobrin
AU  - Vassilev D
AD  - Medica Cor Hospital, Russe, Bulgaria.
FAU - Galie, Nazzareno
AU  - Galie N
AD  - Cardiology Unit, Cardiac Thoracic and Vascular Department, IRCCS Azienda 
      Ospedaliera-Universitaria di Bologna, Department of Medical and Surgical Sciences 
      - DIMEC, Alma Mater Studiorum, University of Bologna, Italy.
FAU - Santulli, Gaetano
AU  - Santulli G
AD  - Dept. of Advanced Biomedical Sciences, University Federico II, Naples, Italy; 
      International Translational Research and Medical Education (ITME) Consortium, 
      Naples, Italy; Department of Medicine (Division of Cardiology) and Department of 
      Molecular Pharmacology, Wilf Family Cardiovascular Research Institute, 
      Einstein-Sinai Diabetes Research Center, The Fleischer Institute for Diabetes and 
      Metabolism, Albert Einstein College of Medicine, NY, USA.
FAU - Calabro, Paolo
AU  - Calabro P
AD  - Department of Translational Medical Sciences, University of Campania 'Luigi 
      Vanvitelli', Naples, Italy; Division of Cardiology, A.O.R.N. "Sant'Anna e San 
      Sebastiano", Caserta, Italy.
FAU - Barbato, Emanuele
AU  - Barbato E
AD  - Department of Clinical and Molecular Medicine, Sapienza University of Rome, Rome, 
      Italy.
FAU - Marfella, Raffaele
AU  - Marfella R
AD  - Department of Translational Medical Sciences, University of Campania 'Luigi 
      Vanvitelli', Naples, Italy.
FAU - Pizzi, Carmine
AU  - Pizzi C
AD  - Cardiology Unit, Cardiac Thoracic and Vascular Department, IRCCS Azienda 
      Ospedaliera-Universitaria di Bologna, Department of Medical and Surgical Sciences 
      - DIMEC, Alma Mater Studiorum, University of Bologna, Italy. Electronic address: 
      carmine.pizzi@unibo.it.
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
DEP - 20230603
PL  - Ireland
TA  - Diabetes Res Clin Pract
JT  - Diabetes research and clinical practice
JID - 8508335
RN  - 0 (Sodium-Glucose Transporter 2 Inhibitors)
RN  - AYI8EX34EU (Creatinine)
SB  - IM
MH  - Humans
MH  - Aged
MH  - *Diabetes Mellitus, Type 2/complications/drug therapy
MH  - *Sodium-Glucose Transporter 2 Inhibitors/adverse effects
MH  - *Percutaneous Coronary Intervention
MH  - Creatinine
MH  - *Myocardial Infarction
MH  - *Renal Insufficiency, Chronic/complications/drug therapy/epidemiology
MH  - *Acute Kidney Injury/chemically induced/epidemiology/complications
MH  - Registries
MH  - Risk Factors
OTO - NOTNLM
OT  - Acute myocardial infarction
OT  - Chronic kidney disease
OT  - Contrast-induced-acute kidney injury
OT  - SGLT2-I
COIS- Declaration of Competing Interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2023/06/06 01:11
MHDA- 2023/08/07 06:41
CRDT- 2023/06/05 19:22
PHST- 2023/05/02 00:00 [received]
PHST- 2023/05/29 00:00 [revised]
PHST- 2023/05/31 00:00 [accepted]
PHST- 2023/08/07 06:41 [medline]
PHST- 2023/06/06 01:11 [pubmed]
PHST- 2023/06/05 19:22 [entrez]
AID - S0168-8227(23)00529-6 [pii]
AID - 10.1016/j.diabres.2023.110766 [doi]
PST - ppublish
SO  - Diabetes Res Clin Pract. 2023 Aug;202:110766. doi: 10.1016/j.diabres.2023.110766. 
      Epub 2023 Jun 3.