PMID- 37277059
OWN - NLM
STAT- Publisher
LR  - 20231016
IS  - 1532-8600 (Electronic)
IS  - 0026-0495 (Linking)
VI  - 148
DP  - 2023 Nov
TI  - LncRNA Nron deficiency protects mice from diet-induced adiposity and hepatic 
      steatosis.
PG  - 155609
LID - S0026-0495(23)00213-5 [pii]
LID - 10.1016/j.metabol.2023.155609 [doi]
AB  - Obesity, as a worldwide healthcare problem, has attracted more and more 
      attention. Here we identify a long non-coding RNA NRON, which is highly conserved 
      across species, as an important regulator of glucose/lipid metabolism and 
      whole-body energy expenditure. Depletion of Nron leads to metabolic benefits in 
      DIO (diet-induced obesity) mice, including reduced body weight and fat mass, 
      improved insulin sensitivity and serum lipid parameters, attenuated hepatic 
      steatosis and enhanced adipose function. Mechanistically, Nron deletion improves 
      hepatic lipid homeostasis via PER2/Rev-Erbalpha/FGF21 axis coupled with AMPK 
      activation, and enhances adipose function via activating the process of 
      triacylglycerol hydrolysis and fatty acid re-esterification (TAG/FA cycling) and 
      coupled metabolic network. These interactive and integrative effects 
      cooperatively account for a healthier metabolic phenotype in NKO (Nron knockout) 
      mice. Genetic or pharmacological inhibition of Nron may have potential for future 
      therapy of obesity.
CI  - Copyright (c) 2023. Published by Elsevier Inc.
FAU - Liu, Bing
AU  - Liu B
AD  - Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, China; Clinic Center of Human Gene 
      Research, Union Hospital, Tongji Medical College, Huazhong University of Science 
      and Technology, Wuhan, China; The First Affiliated Hospital of Xi'an Jiaotong 
      University, Xi'an, China.
FAU - Zhong, Yi
AU  - Zhong Y
AD  - Clinic Center of Human Gene Research, Union Hospital, Tongji Medical College, 
      Huazhong University of Science and Technology, Wuhan, China; Department of 
      Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of 
      Science and Technology, Wuhan, China.
FAU - Huang, Dandan
AU  - Huang D
AD  - Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, China; Clinic Center of Human Gene 
      Research, Union Hospital, Tongji Medical College, Huazhong University of Science 
      and Technology, Wuhan, China.
FAU - Yang, Liuye
AU  - Yang L
AD  - Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, China; Clinic Center of Human Gene 
      Research, Union Hospital, Tongji Medical College, Huazhong University of Science 
      and Technology, Wuhan, China.
FAU - Wang, Pengchao
AU  - Wang P
AD  - Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, China; Clinic Center of Human Gene 
      Research, Union Hospital, Tongji Medical College, Huazhong University of Science 
      and Technology, Wuhan, China.
FAU - Yang, Liu
AU  - Yang L
AD  - Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, China; Clinic Center of Human Gene 
      Research, Union Hospital, Tongji Medical College, Huazhong University of Science 
      and Technology, Wuhan, China; Hubei Key Laboratory of Metabolic Abnormalities and 
      Vascular Aging, Huazhong University of Science and Technology, Wuhan, China; 
      Hubei Clinical Research Center of Metabolic and Cardiovascular Disease, Huazhong 
      University of Science and Technology, Wuhan, China.
FAU - Zhang, Fengxiao
AU  - Zhang F
AD  - Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, China; Clinic Center of Human Gene 
      Research, Union Hospital, Tongji Medical College, Huazhong University of Science 
      and Technology, Wuhan, China; Hubei Key Laboratory of Metabolic Abnormalities and 
      Vascular Aging, Huazhong University of Science and Technology, Wuhan, China; 
      Hubei Clinical Research Center of Metabolic and Cardiovascular Disease, Huazhong 
      University of Science and Technology, Wuhan, China.
FAU - Li, Xiaoguang
AU  - Li X
AD  - Clinic Center of Human Gene Research, Union Hospital, Tongji Medical College, 
      Huazhong University of Science and Technology, Wuhan, China; Hubei Key Laboratory 
      of Metabolic Abnormalities and Vascular Aging, Huazhong University of Science and 
      Technology, Wuhan, China; Hubei Clinical Research Center of Metabolic and 
      Cardiovascular Disease, Huazhong University of Science and Technology, Wuhan, 
      China.
FAU - Liang, Minglu
AU  - Liang M
AD  - Clinic Center of Human Gene Research, Union Hospital, Tongji Medical College, 
      Huazhong University of Science and Technology, Wuhan, China; Hubei Key Laboratory 
      of Metabolic Abnormalities and Vascular Aging, Huazhong University of Science and 
      Technology, Wuhan, China; Hubei Clinical Research Center of Metabolic and 
      Cardiovascular Disease, Huazhong University of Science and Technology, Wuhan, 
      China.
FAU - Huang, Kai
AU  - Huang K
AD  - Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, China; Clinic Center of Human Gene 
      Research, Union Hospital, Tongji Medical College, Huazhong University of Science 
      and Technology, Wuhan, China; Hubei Key Laboratory of Metabolic Abnormalities and 
      Vascular Aging, Huazhong University of Science and Technology, Wuhan, China; 
      Hubei Clinical Research Center of Metabolic and Cardiovascular Disease, Huazhong 
      University of Science and Technology, Wuhan, China. Electronic address: 
      unionhuang@163.com.
FAU - Du, Meng
AU  - Du M
AD  - Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, China; Clinic Center of Human Gene 
      Research, Union Hospital, Tongji Medical College, Huazhong University of Science 
      and Technology, Wuhan, China; Hubei Key Laboratory of Metabolic Abnormalities and 
      Vascular Aging, Huazhong University of Science and Technology, Wuhan, China; 
      Hubei Clinical Research Center of Metabolic and Cardiovascular Disease, Huazhong 
      University of Science and Technology, Wuhan, China. Electronic address: 
      D201378184@alumin.hust.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20230603
PL  - United States
TA  - Metabolism
JT  - Metabolism: clinical and experimental
JID - 0375267
SB  - IM
OTO - NOTNLM
OT  - FGF21
OT  - Hepatic steatosis
OT  - LncRNA
OT  - Obesity
OT  - TAG/FA cycling
COIS- Declaration of competing interest The authors declare no potential conflicts of 
      interest.
EDAT- 2023/06/06 01:11
MHDA- 2023/06/06 01:11
CRDT- 2023/06/05 19:23
PHST- 2023/02/11 00:00 [received]
PHST- 2023/04/27 00:00 [revised]
PHST- 2023/05/30 00:00 [accepted]
PHST- 2023/06/06 01:11 [pubmed]
PHST- 2023/06/06 01:11 [medline]
PHST- 2023/06/05 19:23 [entrez]
AID - S0026-0495(23)00213-5 [pii]
AID - 10.1016/j.metabol.2023.155609 [doi]
PST - ppublish
SO  - Metabolism. 2023 Nov;148:155609. doi: 10.1016/j.metabol.2023.155609. Epub 2023 
      Jun 3.