PMID- 37277102
OWN - NLM
STAT- MEDLINE
DCOM- 20230607
LR  - 20230607
IS  - 1464-5157 (Electronic)
IS  - 0265-6736 (Linking)
VI  - 40
IP  - 1
DP  - 2023
TI  - Occurrence of adverse events after magnetic resonance-guided high-intensity 
      focused ultrasound (MR-HIFU) therapy in symptomatic uterine fibroids-a 
      retrospective case-control study.
PG  - 2219436
LID - 10.1080/02656736.2023.2219436 [doi]
AB  - OBJECTIVES: Our study aims at the comprehensive analysis of adverse events (AEs) 
      in patients with symptomatic uterine fibroids (UFs) who underwent magnetic 
      resonance-guided high-intensity focused ultrasound (MR-HIFU) in the last 6 years 
      in one of the major Polish centers performing this type of therapy. METHODS: The 
      presented retrospective case-control study was conducted in the Department of 
      Obstetrics and Gynecology, Pro-Familia Hospital, Rzeszow in cooperation with the 
      Second Department of Obstetrics and Gynecology, Center of Postgraduate Medical 
      Education, Warsaw. The study enrolled 372 women with symptomatic UFs who 
      underwent MR-HIFU and reported AEs during or after the procedure. The occurrence 
      of particular AEs was analyzed. Statistical comparison of two cohorts (patients 
      with and without AEs) was conducted based on epidemiological factors, UF 
      characteristics, fat layer thickness, the presence of abdominal scars and 
      technical parameters of the procedure. RESULTS: The overall mean occurrence rate 
      of AEs was 8.9% (n = 33). No major AEs were reported. The only statistically 
      significant risk factor of AEs was the treatment of type II UFs according to 
      Funaki (OR 2.12, CI 95%, p = 0.043). Other investigated factors did not have a 
      statistically significant influence on AE occurrence. Abdominal pain was the most 
      common AE. CONCLUSION: Our data showed that MR-HIFU seemed to be a safe 
      procedure. The AE rate after the treatment is relatively low. According to the 
      obtained data it seems that the occurrence of AEs does not depend on the 
      technical parameters of the procedure and the volume, position and location of 
      UFs. Further prospective, randomized studies and with long follow-up are 
      necessary to confirm the final conclusions.
FAU - Kociuba, Jakub
AU  - Kociuba J
AUID- ORCID: 0000-0003-4957-4921
AD  - Second Department of Obstetrics and Gynecology, Center of Postgraduate Medical 
      Education, Warsaw, Poland.
FAU - Lozinski, Tomasz
AU  - Lozinski T
AUID- ORCID: 0000-0002-5129-5262
AD  - Department of Obstetrics and Gynecology, Pro-Familia Hospital, Rzeszow, Poland.
AD  - Department of Gynecology and Obstetrics, Institute of Medical Sciences, Medical 
      College of Rzeszow University, Rzeszow, Poland.
AD  - Development and Research Center of Non-Invasive Therapies, Pro-Familia Hospital, 
      Rzeszow, Poland.
FAU - Zgliczynska, Magdalena
AU  - Zgliczynska M
AUID- ORCID: 0000-0001-7959-3707
AD  - Department of Obstetrics, Perinatology and Neonatology, Center of Postgraduate 
      Medical Education, Warsaw, Poland.
FAU - Byrczak, Maciej
AU  - Byrczak M
AUID- ORCID: 0000-0002-8476-8759
AD  - Second Department of Obstetrics and Gynecology, Center of Postgraduate Medical 
      Education, Warsaw, Poland.
FAU - Dymon, Milosz
AU  - Dymon M
AUID- ORCID: 0000-0002-3989-2013
AD  - Second Department of Obstetrics and Gynecology, Center of Postgraduate Medical 
      Education, Warsaw, Poland.
FAU - Ciebiera, Michal
AU  - Ciebiera M
AUID- ORCID: 0000-0001-5780-5983
AD  - Second Department of Obstetrics and Gynecology, Center of Postgraduate Medical 
      Education, Warsaw, Poland.
AD  - Development and Research Center of Non-Invasive Therapies, Pro-Familia Hospital, 
      Rzeszow, Poland.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Int J Hyperthermia
JT  - International journal of hyperthermia : the official journal of European Society 
      for Hyperthermic Oncology, North American Hyperthermia Group
JID - 8508395
SB  - IM
MH  - Pregnancy
MH  - Female
MH  - Humans
MH  - *Uterine Neoplasms/diagnostic imaging/surgery
MH  - Retrospective Studies
MH  - Case-Control Studies
MH  - *Leiomyoma/diagnostic imaging/surgery
MH  - Magnetic Resonance Imaging/methods
MH  - *High-Intensity Focused Ultrasound Ablation/adverse effects/methods
MH  - Magnetic Resonance Spectroscopy
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Magnetic resonance-guided high-intensity focused ultrasound
OT  - adverse event
OT  - complication
OT  - high intensity focused ultrasound
OT  - leiomyoma
OT  - non-oncologic applications of hyperthermia
OT  - thermal ablation
OT  - ultrasound
OT  - uterine fibroid
EDAT- 2023/06/06 01:11
MHDA- 2023/06/07 06:42
CRDT- 2023/06/05 19:25
PHST- 2023/06/07 06:42 [medline]
PHST- 2023/06/06 01:11 [pubmed]
PHST- 2023/06/05 19:25 [entrez]
AID - 10.1080/02656736.2023.2219436 [doi]
PST - ppublish
SO  - Int J Hyperthermia. 2023;40(1):2219436. doi: 10.1080/02656736.2023.2219436.