PMID- 37279611 OWN - NLM STAT- MEDLINE DCOM- 20230619 LR - 20231116 IS - 1618-131X (Electronic) IS - 1438-4639 (Linking) VI - 251 DP - 2023 Jun TI - Exposure of Swedish adolescents to elements, persistent organic pollutants (POPs), and rapidly excreted substances - The Riksmaten adolescents 2016-17 national survey. PG - 114196 LID - S1438-4639(23)00087-1 [pii] LID - 10.1016/j.ijheh.2023.114196 [doi] AB - Adolescence is a period of significant physiological changes, and likely a sensitive window to chemical exposure. Few nation-wide population-based studies of chemical body burdens in adolescents have been published. In the national dietary survey Riksmaten Adolescents (RMA) 2016-17, over 13 chemical substance groups, including elements, chlorinated/brominated/fluorinated persistent organic pollutants (POPs) were analysed in blood, and in urine metabolites of phthalates/phthalate alternatives, phosphorous flame retardants, polycyclic aromatic hydrocarbons (PAHs), and pesticides, along with bisphenols and biocide/preservative/antioxidant/UV filter substances (N = 1082, ages 11-21). The aim was to characterize the body burdens in a representative population of adolescents in Sweden, and to compare results with human biomonitoring guidance values (HBM-GVs). Cluster analyses and Spearman's rank order correlations suggested that concentrations of substances with known common exposure sources and similar toxicokinetics formed obvious clusters and showed moderate to very strong correlations (r >/= 0.4). No clusters were formed between substances from different matrices. Geometric mean (GM) concentrations of the substances were generally less than 3-fold different from those observed among adolescents in NHANES (USA 2015-16) and GerES V (Germany 2014-17). Notable exceptions were brominated diphenyl ethers (PBDEs) with >20-fold lower GM concentrations, and the biocide triclosan and ultraviolet (UV) filter benzophenone-3 with >15-fold lower mean concentrations in RMA compared to NHANES. Exceedance of the most conservative HBM-GVs were observed for aluminium (Al, 26% of subjects), perfluorooctanesulfonic acid (PFOS, 19%), perfluorooctanoic acid (PFOA, 12%), lead (Pb, 12%), MBP (dibutyl phthalate metabolite, 4.8%), hexachlorobenzene (HCB, 3.1%) and 3-phenoxybenzoic acid (PBA, pyrethroid metabolite, 2.2%). Males showed a higher proportion of exceedances than females for Pb, HCB and PFOS; otherwise no gender-related differences in exceedances were observed. A higher proportion of males than females had a Hazard Index (HI) of substances with liver and kidney toxicity and neurotoxicity >1. Industrialized countries with similarly high standards of living, with some exceptions, show comparable average body burdens of a variety of toxic chemicals among adolescents from the general population. The exceedances of HBM-GVs and HIs strongly suggests that further efforts to limit chemical exposure are warranted. CI - Copyright (c) 2023 The Authors. Published by Elsevier GmbH.. All rights reserved. FAU - Pineda, Sebastian AU - Pineda S AD - Department of Biomedicine and Veterinary Public Health Sciences, Swedish University of Agricultural Sciences, Uppsala, Sweden. Electronic address: sebastian.pineda@slu.se. FAU - Lignell, Sanna AU - Lignell S AD - Department of Risk and Bene fi t Assessment, Swedish National Food Agency, Uppsala, Sweden. FAU - Gyllenhammar, Irina AU - Gyllenhammar I AD - Department of Risk and Bene fi t Assessment, Swedish National Food Agency, Uppsala, Sweden. FAU - Lampa, Erik AU - Lampa E AD - Department of Medical Sciences, Uppsala University, Uppsala, Sweden. FAU - Benskin, Jonathan P AU - Benskin JP AD - Department of Environmental Science, Stockholm University, Stockholm, Sweden. FAU - Lundh, Thomas AU - Lundh T AD - Department of Laboratory Medicine, Division of Occupational and Environmental Medicine, Lund University, Lund, Sweden. FAU - Lindh, Christian AU - Lindh C AD - Department of Laboratory Medicine, Division of Occupational and Environmental Medicine, Lund University, Lund, Sweden. FAU - Kiviranta, Hannu AU - Kiviranta H AD - Department of Health Security, Finnish Institute for Health and Welfare, Helsinki, Finland. FAU - Glynn, Anders AU - Glynn A AD - Department of Biomedicine and Veterinary Public Health Sciences, Swedish University of Agricultural Sciences, Uppsala, Sweden. LA - eng PT - Journal Article DEP - 20230604 PL - Germany TA - Int J Hyg Environ Health JT - International journal of hygiene and environmental health JID - 100898843 RN - 0 (Persistent Organic Pollutants) RN - 0 (Hydrocarbons, Chlorinated) RN - 4Z87H0LKUY (Hexachlorobenzene) RN - 2P299V784P (Lead) RN - 0 (Environmental Pollutants) RN - 0 (Halogenated Diphenyl Ethers) SB - IM MH - Male MH - Female MH - Humans MH - Adolescent MH - Persistent Organic Pollutants MH - Environmental Monitoring MH - Sweden MH - *Hydrocarbons, Chlorinated MH - Nutrition Surveys MH - Hexachlorobenzene/analysis MH - Lead/analysis MH - *Environmental Pollutants MH - Halogenated Diphenyl Ethers OTO - NOTNLM OT - Adolescents OT - Biomonitoring OT - Chemical mixtures OT - Hazard index OT - Neurotoxic OT - Pollutants COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2023/06/06 19:13 MHDA- 2023/06/19 13:08 CRDT- 2023/06/06 18:00 PHST- 2023/02/03 00:00 [received] PHST- 2023/05/24 00:00 [revised] PHST- 2023/05/26 00:00 [accepted] PHST- 2023/06/19 13:08 [medline] PHST- 2023/06/06 19:13 [pubmed] PHST- 2023/06/06 18:00 [entrez] AID - S1438-4639(23)00087-1 [pii] AID - 10.1016/j.ijheh.2023.114196 [doi] PST - ppublish SO - Int J Hyg Environ Health. 2023 Jun;251:114196. doi: 10.1016/j.ijheh.2023.114196. Epub 2023 Jun 4.