PMID- 37279647
OWN - NLM
STAT- MEDLINE
DCOM- 20230608
LR  - 20240124
IS  - 2309-4990 (Electronic)
IS  - 1022-5536 (Linking)
VI  - 31
IP  - 2
DP  - 2023 May-Aug
TI  - The analgesic effect and safety of duloxetine in total knee arthroplasty: A 
      systematic review.
PG  - 10225536231177482
LID - 10.1177/10225536231177482 [doi]
AB  - Background: Duloxetine is a serotonin and norepinephrine reuptake inhibitor 
      (SNRI) with clinical efficacy in chronic pain conditions. In this study, we aim 
      to evaluate the analgesic effect and safety of duloxetine in total knee 
      arthroplasty (TKA). Methods: A systematic search was completed on MEDLINE, 
      PsycINFO, and Embase from inception to December 2022 to find relevant articles. 
      We used Cochrane methodology to evaluate the bias of included studies. 
      Investigated outcomes included postoperative pain, opioid consumption, adverse 
      events (AEs), range of motion (ROM), emotional and physical function, patient 
      satisfaction, patient-controlled analgesia (PCA), knee-specific outcomes, wound 
      complications, skin temperature, inflammatory markers, length of stay, and 
      incidence of manipulations. Results: Nine articles involving 942 participants 
      were included in our systematic review. Out of nine papers, eight were randomized 
      clinical trials and one was a retrospective study. The results of these studies 
      indicated the analgesic effect of duloxetine on postoperative pain, which was 
      measured using numeric rating scale and visual analogue scale. Deluxetine was 
      also effective in reducing the morphine requirement and wound complications and 
      enhancing patient satisfaction after surgery. However, the results on ROM, PCA, 
      and knee-specific outcomes were contraventional. Deluxetine was generally safe 
      without serious AEs. The most common AEs included headache, nausea, vomiting, dry 
      mouth, and constipation. Conclusion: Duloxetine may be an effective treatment 
      option for postoperative pain following TKA, but further rigorously designed and 
      well-controlled randomized trials are required.
FAU - Kouhestani, Emad
AU  - Kouhestani E
AUID- ORCID: 0000-0001-9526-468X
AD  - Department of Orthopedic Surgery, Shahid Beheshti University of Medical Sciences, 
      Tehran, Iran.
AD  - Bone Joint and Related Tissues Research Center, Akhtar Orthopedic Hospital, 
      Shahid Beheshti University of Medical Sciences, Tehran, Iran.
FAU - Minaei, Reza
AU  - Minaei R
AD  - Department of Orthopedic Surgery, Shahid Beheshti University of Medical Sciences, 
      Tehran, Iran.
AD  - Bone Joint and Related Tissues Research Center, Akhtar Orthopedic Hospital, 
      Shahid Beheshti University of Medical Sciences, Tehran, Iran.
FAU - Salimi, Amir
AU  - Salimi A
AD  - School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
FAU - Mehrabi, Yoosef
AU  - Mehrabi Y
AD  - School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
FAU - Meshkat, Shakila
AU  - Meshkat S
AD  - School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
LA  - eng
PT  - Journal Article
PT  - Review
PT  - Systematic Review
PL  - England
TA  - J Orthop Surg (Hong Kong)
JT  - Journal of orthopaedic surgery (Hong Kong)
JID - 9440382
RN  - 9044SC542W (Duloxetine Hydrochloride)
RN  - 0 (Analgesics, Opioid)
SB  - IM
CIN - J Orthop Surg (Hong Kong). 2023 Sep-Dec;31(3):10225536231198768. PMID: 37694724
MH  - Humans
MH  - Duloxetine Hydrochloride/therapeutic use
MH  - *Arthroplasty, Replacement, Knee/adverse effects/methods
MH  - Retrospective Studies
MH  - Pain, Postoperative/drug therapy
MH  - Analgesics, Opioid/therapeutic use
MH  - Randomized Controlled Trials as Topic
OTO - NOTNLM
OT  - duloxetine
OT  - postoperative pain
OT  - safety
OT  - systematic review
OT  - total knee arthroplasty
EDAT- 2023/06/07 01:07
MHDA- 2023/06/08 06:42
CRDT- 2023/06/06 18:03
PHST- 2023/06/08 06:42 [medline]
PHST- 2023/06/07 01:07 [pubmed]
PHST- 2023/06/06 18:03 [entrez]
AID - 10.1177/10225536231177482 [doi]
PST - ppublish
SO  - J Orthop Surg (Hong Kong). 2023 May-Aug;31(2):10225536231177482. doi: 
      10.1177/10225536231177482.