PMID- 37280149
OWN - NLM
STAT- MEDLINE
DCOM- 20240119
LR  - 20240119
IS  - 1758-535X (Electronic)
IS  - 1079-5006 (Linking)
VI  - 79
IP  - 1
DP  - 2024 Jan 1
TI  - Plasma Level of ATPase Inhibitory Factor 1 and Intrinsic Capacity in 
      Community-Dwelling Older Adults: Prospective Data From the MAPT Study.
LID - glad142 [pii]
LID - 10.1093/gerona/glad142 [doi]
AB  - BACKGROUND: Intrinsic capacity (IC) is a concept related to functionality that 
      reflects healthy aging. ATPase inhibitory factor 1 (IF1) is a multifaceted 
      protein that regulates mitochondrial oxidative phosphorylation (OXPHOS), and may 
      be involved in IC. The objective of this study is to investigate the association 
      between plasma levels of IF1 and IC changes in community-dwelling older adults. 
      METHODS: Community-dwelling older adults from the Multidomain Alzheimer 
      Preventive Trial (MAPT Study) were enrolled in this study. A composite IC score 
      was calculated based on 4 IC domains: locomotion, psychological dimension, 
      cognition, and vitality (with data available annually over 4 years of follow-up). 
      Secondary analyses were conducted on the sensory domain (with data available only 
      for 1 year of follow-up). Mixed-model linear regression adjusted for confounders 
      was conducted. RESULTS: A total of 1 090 participants with usable IF1 values were 
      included in the study (75.3 +/- 4.4 years; 64% females). Compared to the lowest 
      quartile, both the low- and high-intermediate IF1 quartiles were found to be 
      cross-sectionally associated with greater composite IC scores across 4 domains 
      (betalow-intermediate, 1.33; 95% confidence interval [CI] 0.06-2.60 and 
      betahigh-intermediate, 1.78; 95% CI 0.49-3.06). In the secondary analyses, the 
      highest quartile was found to be associated with a slower decline in composite IC 
      scores across 5 domains over 1 year (betahigh 1.60; 95% CI 0.06-3.15). The low- and 
      high-intermediate IF1 quartiles were also found to be cross-sectionally 
      associated with greater locomotion (betalow-intermediate, 2.72; 95% CI 0.36-5.08) 
      and vitality scores (betahigh-intermediate, 1.59; 95% CI 0.06-3.12), respectively. 
      CONCLUSIONS: This study is the first to demonstrate that levels of circulating 
      IF1, a mitochondrial-related biomarker, are associated with IC composite scores 
      in both cross-sectional and prospective analyses among community-dwelling older 
      adults. However, further research is needed to confirm these findings and 
      elucidate the potential underlying mechanisms that may explain these 
      associations.
CI  - (c) The Author(s) 2023. Published by Oxford University Press on behalf of The 
      Gerontological Society of America. All rights reserved. For permissions, please 
      e-mail: journals.permissions@oup.com.
FAU - da Silva, Jaqueline Aragoni
AU  - da Silva JA
AUID- ORCID: 0000-0001-6344-9073
AD  - Institut du Vieillissement, Gerontopole de Toulouse, Centre 
      Hospitalo-Universitaire de Toulouse, Toulouse, France.
FAU - Martinez, Laurent O
AU  - Martinez LO
AUID- ORCID: 0000-0002-0985-3152
AD  - LiMitAging, Institut des Maladies Metaboliques et Cardiovasculaires, I2MC, 
      Universite de Toulouse, INSERM, Universite Toulouse III - Paul Sabatier (UPS), 
      Toulouse, France.
FAU - Rolland, Yves
AU  - Rolland Y
AUID- ORCID: 0000-0002-1157-0215
AD  - Institut du Vieillissement, Gerontopole de Toulouse, Centre 
      Hospitalo-Universitaire de Toulouse, Toulouse, France.
AD  - CERPOP UMR 1295, University of Toulouse III, INSERM, UPS, Toulouse, France.
FAU - Najib, Souad
AU  - Najib S
AUID- ORCID: 0000-0001-5509-1411
AD  - LiMitAging, Institut des Maladies Metaboliques et Cardiovasculaires, I2MC, 
      Universite de Toulouse, INSERM, Universite Toulouse III - Paul Sabatier (UPS), 
      Toulouse, France.
FAU - Croyal, Mikael
AU  - Croyal M
AUID- ORCID: 0000-0002-5449-5817
AD  - Nantes Universite, CHU Nantes, CNRS, INSERM, l'institut du Thorax, BioCore, US16, 
      SFR Bonamy, F-44000 Nantes, France.
AD  - CRNH-Ouest Mass Spectrometry Core Facility, Nantes, France.
FAU - Perret, Bertrand
AU  - Perret B
AUID- ORCID: 0000-0001-7568-445X
AD  - LiMitAging, Institut des Maladies Metaboliques et Cardiovasculaires, I2MC, 
      Universite de Toulouse, INSERM, Universite Toulouse III - Paul Sabatier (UPS), 
      Toulouse, France.
FAU - Jabrane-Ferrat, Nabila
AU  - Jabrane-Ferrat N
AUID- ORCID: 0000-0003-4809-7836
AD  - Toulouse Institute for Infectious and Inflammatory Diseases (Infinity), 
      INSERM-CNRS-University Toulouse III, Toulouse, France.
FAU - El Costa, Hicham
AU  - El Costa H
AUID- ORCID: 0000-0001-8889-9759
AD  - Toulouse Institute for Infectious and Inflammatory Diseases (Infinity), 
      INSERM-CNRS-University Toulouse III, Toulouse, France.
FAU - Guyonnet, Sophie
AU  - Guyonnet S
AUID- ORCID: 0000-0001-9527-5282
AD  - Institut du Vieillissement, Gerontopole de Toulouse, Centre 
      Hospitalo-Universitaire de Toulouse, Toulouse, France.
AD  - CERPOP UMR 1295, University of Toulouse III, INSERM, UPS, Toulouse, France.
FAU - Vellas, Bruno
AU  - Vellas B
AUID- ORCID: 0000-0002-7678-5065
AD  - Institut du Vieillissement, Gerontopole de Toulouse, Centre 
      Hospitalo-Universitaire de Toulouse, Toulouse, France.
AD  - CERPOP UMR 1295, University of Toulouse III, INSERM, UPS, Toulouse, France.
FAU - de Souto Barreto, Philipe
AU  - de Souto Barreto P
AUID- ORCID: 0000-0002-8860-425X
AD  - Institut du Vieillissement, Gerontopole de Toulouse, Centre 
      Hospitalo-Universitaire de Toulouse, Toulouse, France.
AD  - CERPOP UMR 1295, University of Toulouse III, INSERM, UPS, Toulouse, France.
CN  - MAPT/DSA group
LA  - eng
GR  - 1901175/Region Occitanie/Pyrenees-Mediterranee/
GR  - MP0022856/European Regional Development Fund/
GR  - Alzheimer Prevention in Occitania and Catalonia/
GR  - Saint Louis University/
GR  - Gerontopole of Toulouse/
GR  - French Ministry of Health/
GR  - Pierre Fabre Research Institute/
GR  - ExonHit Therapeutics SA/
GR  - Avid Radiopharmaceuticals Inc/
GR  - University Hospital Center of Toulouse/
GR  - Association Monegasque pour la Recherche sur la maladie d'Alzheimer/
GR  - INSERM-University of Toulouse III UMR 1295 (CERPOP) Research Unit/
PT  - Journal Article
PL  - United States
TA  - J Gerontol A Biol Sci Med Sci
JT  - The journals of gerontology. Series A, Biological sciences and medical sciences
JID - 9502837
RN  - 0 (ATPIF1 protein, human)
RN  - 0 (ATPase Inhibitory Protein)
SB  - IM
MH  - Aged
MH  - Female
MH  - Humans
MH  - Male
MH  - *Alzheimer Disease
MH  - Cross-Sectional Studies
MH  - *Independent Living
MH  - Prospective Studies
MH  - *ATPase Inhibitory Protein/blood
OTO - NOTNLM
OT  - ATP synthase
OT  - Healthy aging
OT  - Intrinsic capacity
OT  - Mitochondria
OT  - Mitochondrial dysfunction
EDAT- 2023/06/07 01:07
MHDA- 2023/12/22 06:43
CRDT- 2023/06/06 22:03
PHST- 2022/10/14 00:00 [received]
PHST- 2023/12/22 06:43 [medline]
PHST- 2023/06/07 01:07 [pubmed]
PHST- 2023/06/06 22:03 [entrez]
AID - 7191210 [pii]
AID - 10.1093/gerona/glad142 [doi]
PST - ppublish
SO  - J Gerontol A Biol Sci Med Sci. 2024 Jan 1;79(1):glad142. doi: 
      10.1093/gerona/glad142.