PMID- 37280611
OWN - NLM
STAT- MEDLINE
DCOM- 20230608
LR  - 20230610
IS  - 1471-2415 (Electronic)
IS  - 1471-2415 (Linking)
VI  - 23
IP  - 1
DP  - 2023 Jun 6
TI  - Hyperreflective material in patients with non-neovascular pachychoroid disease.
PG  - 255
LID - 10.1186/s12886-023-03011-2 [doi]
LID - 255
AB  - BACKGROUND: This study aimed to report eleven cases of non-neovascular 
      pachychoroid disease with hyperreflective material (HRM) that occurred in 
      Japanese patients. METHODS: A retrospective review of data from eleven patients 
      who had non-neovascular retinal pigment epithelium (RPE) protrusion with HRM in 
      the neurosensory retina between March 2017 and June 2022 was conducted. Clinical 
      examination, color fundus photography, fluorescein angiography, spectral-domain 
      optical coherence tomography (SD-OCT), and OCT angiography data were analyzed. 
      Main outcome measures were patient characteristics, changes in SD-OCT findings, 
      and symptom outcomes. RESULTS: All cases had RPE protrusion and HRM with dilated 
      choroidal veins, which were characteristic of pachychoroid disease. However, none 
      of the cases had macular neovascularization (MNV). In 9 eyes (81.8%), HRM 
      improved spontaneously without intervention and resulted in alterations in RPE, 
      referred to as pachychoroid pigment epitheliopathy (PPE) or focal choroidal 
      excavation (FCE). In these cases, symptoms such as metamorphopsia and distortion 
      improved without treatment. In the remaining two cases (18.2%), HRM still 
      persisted during the follow-up period. CONCLUSION: There are some cases of 
      non-neovascular pachychoroid disorder with HRM, which might be a new entity of 
      pachychoroid spectrum disease or an early stage of PPE or FCE. These cases should 
      not be misdiagnosed as MNV, and careful observation is necessary.
CI  - (c) 2023. The Author(s).
FAU - Maruyama-Inoue, Maiko
AU  - Maruyama-Inoue M
AUID- ORCID: 0000-0002-8191-1329
AD  - Department of Ophthalmology and Micro-Technology, Yokohama City University, 4-57 
      Urafune-cho, Minami-ku, Kanagawa, 232 - 0024, Yokohama, Japan. 
      maicoo@urahp.yokohama-cu.ac.jp.
FAU - Yanagi, Yasuo
AU  - Yanagi Y
AD  - Department of Ophthalmology and Micro-Technology, Yokohama City University, 4-57 
      Urafune-cho, Minami-ku, Kanagawa, 232 - 0024, Yokohama, Japan.
FAU - Mohamed, Shaheeda
AU  - Mohamed S
AD  - Department of Ophthalmology and Visual Sciences, Hong Kong Eye Hospital, The 
      Chinese University of Hong Kong, Hong Kong Special Administrative Region, Hong 
      Kong, China.
FAU - Inoue, Tatsuya
AU  - Inoue T
AD  - Department of Ophthalmology and Micro-Technology, Yokohama City University, 4-57 
      Urafune-cho, Minami-ku, Kanagawa, 232 - 0024, Yokohama, Japan.
FAU - Kitajima, Yoko
AU  - Kitajima Y
AD  - Department of Ophthalmology and Micro-Technology, Yokohama City University, 4-57 
      Urafune-cho, Minami-ku, Kanagawa, 232 - 0024, Yokohama, Japan.
FAU - Ikeda, Shoko
AU  - Ikeda S
AD  - Department of Ophthalmology and Micro-Technology, Yokohama City University, 4-57 
      Urafune-cho, Minami-ku, Kanagawa, 232 - 0024, Yokohama, Japan.
FAU - Kadonosono, Kazuaki
AU  - Kadonosono K
AD  - Department of Ophthalmology and Micro-Technology, Yokohama City University, 4-57 
      Urafune-cho, Minami-ku, Kanagawa, 232 - 0024, Yokohama, Japan.
LA  - eng
PT  - Journal Article
DEP - 20230606
PL  - England
TA  - BMC Ophthalmol
JT  - BMC ophthalmology
JID - 100967802
SB  - IM
MH  - Humans
MH  - *Choroid/blood supply
MH  - *Retinal Pigment Epithelium
MH  - Fluorescein Angiography/methods
MH  - Tomography, Optical Coherence/methods
MH  - Neovascularization, Pathologic
MH  - Retrospective Studies
PMC - PMC10245594
OTO - NOTNLM
OT  - Age-related macular degeneration
OT  - Drusen ooze
OT  - Focal choroidal excavation
OT  - Hyperreflective foci
OT  - Idiopathic choroidal neovascularization
OT  - Macular neovascularization
OT  - Pachychoroid
OT  - Pachychoroid pigment epitheliopathy
OT  - Subretinal hyperreflective material
COIS- The authors declare no competing interests.
EDAT- 2023/06/07 01:07
MHDA- 2023/06/08 06:42
PMCR- 2023/06/06
CRDT- 2023/06/06 23:40
PHST- 2022/12/22 00:00 [received]
PHST- 2023/06/01 00:00 [accepted]
PHST- 2023/06/08 06:42 [medline]
PHST- 2023/06/07 01:07 [pubmed]
PHST- 2023/06/06 23:40 [entrez]
PHST- 2023/06/06 00:00 [pmc-release]
AID - 10.1186/s12886-023-03011-2 [pii]
AID - 3011 [pii]
AID - 10.1186/s12886-023-03011-2 [doi]
PST - epublish
SO  - BMC Ophthalmol. 2023 Jun 6;23(1):255. doi: 10.1186/s12886-023-03011-2.