PMID- 37282363
OWN - NLM
STAT- MEDLINE
DCOM- 20231102
LR  - 20231102
IS  - 1476-4431 (Electronic)
IS  - 1476-4431 (Linking)
VI  - 33
IP  - 4
DP  - 2023 Jul-Aug
TI  - Total serum and ionized magnesium concentrations in healthy and hospitalized 
      dogs.
PG  - 427-434
LID - 10.1111/vec.13302 [doi]
AB  - OBJECTIVE: To determine if an association between ionized magnesium (iMg) and 
      total magnesium (tMg) exists in healthy and hospitalized dogs admitted through an 
      emergency service and to assess the associations between iMg and tMg with total 
      protein, albumin, ionized calcium, and total calcium. DESIGN: Prospective cohort 
      study. SETTING: Veterinary teaching hospital. ANIMALS: Sixty-nine dogs were 
      enrolled. The healthy control group (group 1) included 24 dogs, and the 
      hospitalized group (group 2) included 45 dogs. INTERVENTIONS: None. MEASUREMENTS 
      AND MAIN RESULTS: For both groups, signalment, a venous blood gas, and serum 
      biochemistry were obtained. In addition, the presumptive diagnosis was recorded 
      for group 2. Blood was obtained prior to any therapeutic interventions. Group 1 
      tMg was within the reference interval (RI), and the values for iMg were used to 
      provide a healthy group range (HGR) of 0.44-0.50 mmol/L. Group 2 tMg was within 
      the RI, but iMg was below the calculated HGR range (group 2 median 
      iMg = 0.4 mmol/L; range = 0.27-0.70). There was a significant positive 
      correlation between iMg and tMg in each group (group 1: r = 0.6713, P = 0.0003; 
      group 2: r = 0.5312, P = 0.0002). Ionized Mg and tMg were not significantly 
      associated with any of the other evaluated variables in either group. 
      CONCLUSIONS: Ionized Mg and tMg were significantly associated in both healthy and 
      hospitalized dogs, but the relationship was weaker in the hospitalized dogs 
      compared with the healthy population. For hospitalized dogs, the relationship was 
      weak enough to question the validity of using iMg and tMg interchangeably to 
      track magnesium status.
CI  - (c) Veterinary Emergency and Critical Care Society 2023.
FAU - Murray, Megan E
AU  - Murray ME
AUID- ORCID: 0000-0003-1941-1443
AD  - School of Veterinary Medicine, University of Pennsylvania, Philadelphia, 
      Pennsylvania, USA.
FAU - Boiron, Ludivine
AU  - Boiron L
AUID- ORCID: 0000-0003-0731-5593
AD  - School of Veterinary Medicine, University of Pennsylvania, Philadelphia, 
      Pennsylvania, USA.
FAU - Buriko, Yekaterina
AU  - Buriko Y
AD  - School of Veterinary Medicine, University of Pennsylvania, Philadelphia, 
      Pennsylvania, USA.
FAU - Drobatz, Kenneth
AU  - Drobatz K
AD  - School of Veterinary Medicine, University of Pennsylvania, Philadelphia, 
      Pennsylvania, USA.
FAU - Waddell, Lori S
AU  - Waddell LS
AD  - School of Veterinary Medicine, University of Pennsylvania, Philadelphia, 
      Pennsylvania, USA.
LA  - eng
PT  - Journal Article
DEP - 20230606
PL  - United States
TA  - J Vet Emerg Crit Care (San Antonio)
JT  - Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001)
JID - 101152804
RN  - I38ZP9992A (Magnesium)
RN  - SY7Q814VUP (Calcium)
RN  - 0 (Electrolytes)
SB  - IM
MH  - Humans
MH  - Dogs
MH  - Animals
MH  - *Magnesium
MH  - *Calcium
MH  - Prospective Studies
MH  - Hospitals, Animal
MH  - Hospitals, Teaching
MH  - Electrolytes
OTO - NOTNLM
OT  - calcium
OT  - clinical pathology
OT  - critical care
OT  - magnesium
OT  - small animal
EDAT- 2023/06/07 06:42
MHDA- 2023/06/07 06:43
CRDT- 2023/06/07 02:14
PHST- 2022/05/10 00:00 [revised]
PHST- 2022/01/13 00:00 [received]
PHST- 2022/05/28 00:00 [accepted]
PHST- 2023/06/07 06:43 [medline]
PHST- 2023/06/07 06:42 [pubmed]
PHST- 2023/06/07 02:14 [entrez]
AID - 10.1111/vec.13302 [doi]
PST - ppublish
SO  - J Vet Emerg Crit Care (San Antonio). 2023 Jul-Aug;33(4):427-434. doi: 
      10.1111/vec.13302. Epub 2023 Jun 6.