PMID- 37289316
OWN - NLM
STAT- MEDLINE
DCOM- 20230911
LR  - 20230923
IS  - 1678-4405 (Electronic)
IS  - 1517-8382 (Print)
IS  - 1517-8382 (Linking)
VI  - 54
IP  - 3
DP  - 2023 Sep
TI  - Paracoccidioidomycosis cases by Paracoccidioides lutzii in southeastern Brazil.
PG  - 1761-1767
LID - 10.1007/s42770-023-01019-w [doi]
AB  - BACKGROUND AND OBJECTIVE: Paracoccidioidomycosis (PCM) is a systemic fungal 
      disease caused by the thermodimorphic fungi Paracoccidioides spp. Their 
      distribution is highly variable. Paracoccidioides lutzii is predominantly found 
      in North and Middle-West Brazil and Ecuador. This study evaluated the 
      clinicopathological characteristics of 10 patients diagnosed with PCM caused by 
      P. lutzii in a reference center located in southeastern Brazil. DESIGN: Double 
      immunodiffusion assay (DID) was used to investigate 35 patients' sera with 
      negative serology for P. brasiliensis against a P. lutzii CFA (cell-free 
      antigen). RESULTS: Out of the 35 retested patients, 10 (28.6%) were positive for 
      P. lutzii CFA. Four patients did not report any displacement to P. lutzii endemic 
      areas. Our results reinforce the importance of using different antigens when 
      testing patients with clinical manifestations of PCM and negative serological 
      tests for P. brasiliensis, primarily in cases of the report of displacement to or 
      former residence in P. lutzii endemic regions. CONCLUSIONS: The availability of 
      tests for different Paracoccidioides species antigens is fundamental for reaching 
      an adequate diagnosis, patient follow-up, and definition of prognosis.
CI  - (c) 2023. The Author(s) under exclusive licence to Sociedade Brasileira de 
      Microbiologia.
FAU - Kruschewsky, Wdson Luis Lima
AU  - Kruschewsky WLL
AD  - Cassiano Antonio Moraes University Hospital (HUCAM), Federal University of 
      Espirito Santo (UFES), Vitoria, Espirito Santo, Brazil.
FAU - Patricio, Suzana Alves
AU  - Patricio SA
AD  - Department of General and Specialized Surgery, Federal Fluminense University 
      (UFF), Niteroi, Rio de Janeiro, Brazil.
FAU - Bahiense, Isabela Cruz
AU  - Bahiense IC
AD  - Infectious Diseases Postgraduate Program, Center for Research in Medical 
      Mycology, Federal University of Espirito Santo (UFES), Espirito Santo, Brazil.
FAU - Maifrede, Simone Bravim
AU  - Maifrede SB
AD  - Center for Research in Medical Mycology, Department of Pathology, Federal 
      University of Espirito Santo (UFES), Vitoria - ES, Brazil.
FAU - Possa, Ana Paula
AU  - Possa AP
AD  - Laboratory of Emerging Fungal Pathogens, Department of Microbiology, Immunology, 
      and Parasitology, Discipline of Cellular Biology, Federal University of Sao Paulo 
      (UNIFESP), Sao Paulo, Brazil.
FAU - de Camargo, Zoilo Pires
AU  - de Camargo ZP
AD  - Laboratory of Emerging Fungal Pathogens, Department of Microbiology, Immunology, 
      and Parasitology, Discipline of Cellular Biology, Federal University of Sao Paulo 
      (UNIFESP), Sao Paulo, Brazil.
FAU - Rodrigues, Anderson Messias
AU  - Rodrigues AM
AD  - Laboratory of Emerging Fungal Pathogens, Department of Microbiology, Immunology, 
      and Parasitology, Discipline of Cellular Biology, Federal University of Sao Paulo 
      (UNIFESP), Sao Paulo, Brazil.
FAU - Pecanha, Paulo Mendes
AU  - Pecanha PM
AD  - Cassiano Antonio Moraes University Hospital (HUCAM), Federal University of 
      Espirito Santo (UFES), Vitoria, Espirito Santo, Brazil.
AD  - Department of Clinical Medicine, Espirito Santo Federal University - UFES, Avenue 
      Marechal Campos, 1468, Maruipe, Espirito Santo, Vitoria, CEP 29047-105, Brazil.
FAU - Falqueto, Aloisio
AU  - Falqueto A
AD  - Cassiano Antonio Moraes University Hospital (HUCAM), Federal University of 
      Espirito Santo (UFES), Vitoria, Espirito Santo, Brazil.
AD  - Department of Social Medicine, Espirito Santo Federal University - UFES, Avenue 
      Marechal Campos, Maruipe, Vitoria, Espirito Santo, 1468, CEP 29047-105, Brazil.
FAU - Grao-Velloso, Tania Regina
AU  - Grao-Velloso TR
AUID- ORCID: 0000-0001-6865-7955
AD  - Department of Clinical Dentistry Federal, University of Espirito Santo - UFES, 
      Marechal Campos Avenue, CEP 29, Vitoria-ES, 1468040-090, Brazil. 
      taniag.velloso@gmail.com.
FAU - Goncalves, Sarah Santos
AU  - Goncalves SS
AD  - Infectious Diseases Postgraduate Program, Center for Research in Medical 
      Mycology, Federal University of Espirito Santo (UFES), Espirito Santo, Brazil.
AD  - Center for Research in Medical Mycology, Department of Pathology, Federal 
      University of Espirito Santo (UFES), Vitoria - ES, Brazil.
LA  - eng
PT  - Journal Article
DEP - 20230608
PL  - Brazil
TA  - Braz J Microbiol
JT  - Brazilian journal of microbiology : [publication of the Brazilian Society for 
      Microbiology]
JID - 101095924
RN  - 0 (Antigens, Fungal)
RN  - Paracoccidioides lutzii
SB  - IM
EIN - Braz J Microbiol. 2023 Jul 18;:. PMID: 37460870
MH  - Humans
MH  - *Paracoccidioidomycosis/diagnosis/epidemiology
MH  - *Paracoccidioides/genetics
MH  - Brazil/epidemiology
MH  - Antigens, Fungal
PMC - PMC10485217
OTO - NOTNLM
OT  - Double immunodiffusion assay
OT  - Endemic mycosis
OT  - Paracoccidioides lutzii
OT  - Paracoccidioidomycosis
COIS- The authors declare no competing interests.
EDAT- 2023/06/08 13:08
MHDA- 2023/09/11 06:42
PMCR- 2024/06/08
CRDT- 2023/06/08 11:09
PHST- 2023/01/22 00:00 [received]
PHST- 2023/05/25 00:00 [accepted]
PHST- 2024/06/08 00:00 [pmc-release]
PHST- 2023/09/11 06:42 [medline]
PHST- 2023/06/08 13:08 [pubmed]
PHST- 2023/06/08 11:09 [entrez]
AID - 10.1007/s42770-023-01019-w [pii]
AID - 1019 [pii]
AID - 10.1007/s42770-023-01019-w [doi]
PST - ppublish
SO  - Braz J Microbiol. 2023 Sep;54(3):1761-1767. doi: 10.1007/s42770-023-01019-w. Epub 
      2023 Jun 8.