PMID- 37289437
OWN - NLM
STAT- MEDLINE
DCOM- 20240111
LR  - 20240202
IS  - 2831-090X (Electronic)
IS  - 2831-0896 (Print)
IS  - 2831-0896 (Linking)
VI  - 24
IP  - 1
DP  - 2024 Jan 3
TI  - Alcoholic extracts of Teucrium polium exhibit remarkable anti-inflammatory 
      activity: In vivo study.
PG  - 82-88
LID - 10.17305/bb.2023.9239 [doi]
AB  - Teucrium polium (germander, Lamiaceae) is a local plant in Qatar that has been 
      used in folk medicine to treat numerous illnesses. It is known for its 
      antioxidant, analgesic, anticancer, and antibacterial activities. This study 
      aimed to evaluate the anti-inflammatory activity of Teucrium polium (TP) extract 
      by alpha-carrageen-induced paw edema in adult Sprague Dawley rats. The animals were 
      randomly grouped into control, acute inflammation, and plant extract groups. 
      Acute inflammation was induced by a sub-plantar injection of 100 microL of 1% 
      alpha-carrageenan into the rat's right hind paw. Three different doses of the 
      ethanolic extract of TP were tested at different time periods (1, 3, and 5 
      hours). All doses of the TP ethanolic extract showed significant inhibition of 
      alpha-carrageenan-induced rat paw edema in a dose-dependent manner in both early and 
      late phases of edema formation. The size of the alpha-carrageen induced paw edema was 
      significantly reduced one, three, and five hours after TP extract injection 
      compared to the acute inflammation group. This inhibition was accompanied by high 
      expression of interleukin 10 (IL-10) and low expression of monocyte 
      chemoattractant protein 1 (MCP-1), IL-1beta and tumor necrosis factor alpha (TNF-alpha). 
      The results indicated that the ethanolic extracts of TP possess significant 
      anti-inflammatory and potential pharmaceutical properties.
FAU - Al-Naemi, Hamda A
AU  - Al-Naemi HA
AD  - Laboratory Animal Research Centre, Qatar University, Doha, Qatar; Department of 
      Biological and Environmental Sciences, Qatar University, Doha, Qatar.
FAU - Alasmar, Reem Moath
AU  - Alasmar RM
AD  - Laboratory Animal Research Centre, Qatar University, Doha, Qatar.
FAU - Al-Ghanim, Kaltham
AU  - Al-Ghanim K
AD  - Social and Economic Survey Research Institute (SESRI), Qatar University, Doha, 
      Qatar.
LA  - eng
PT  - Journal Article
DEP - 20240103
PL  - Bosnia and Herzegovina
TA  - Biomol Biomed
JT  - Biomolecules & biomedicine
JID - 9918522188506676
RN  - 9000-07-1 (Carrageenan)
RN  - 0 (Plant Extracts)
RN  - 0 (Anti-Inflammatory Agents)
SB  - IM
MH  - Rats
MH  - Animals
MH  - Carrageenan/toxicity
MH  - *Teucrium
MH  - Rats, Sprague-Dawley
MH  - Plant Extracts/pharmacology
MH  - Anti-Inflammatory Agents/pharmacology
MH  - Inflammation/chemically induced
MH  - Edema/chemically induced
PMC - PMC10787626
COIS- Conflicts of interest: Authors declare no conflicts of interest.
EDAT- 2023/06/08 13:08
MHDA- 2024/01/11 07:43
PMCR- 2024/02/01
CRDT- 2023/06/08 11:22
PHST- 2023/04/30 00:00 [received]
PHST- 2023/05/26 00:00 [accepted]
PHST- 2024/01/11 07:43 [medline]
PHST- 2023/06/08 13:08 [pubmed]
PHST- 2023/06/08 11:22 [entrez]
PHST- 2024/02/01 00:00 [pmc-release]
AID - BB-24-82 [pii]
AID - 10.17305/bb.2023.9239 [doi]
PST - epublish
SO  - Biomol Biomed. 2024 Jan 3;24(1):82-88. doi: 10.17305/bb.2023.9239.