PMID- 37291156
OWN - NLM
STAT- MEDLINE
DCOM- 20230612
LR  - 20231121
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 13
IP  - 1
DP  - 2023 Jun 8
TI  - The effects of trans fat diet intake on metabolic parameters and pancreatic 
      tissue in offspring of prenatal bisphenol A exposed rats.
PG  - 9322
LID - 10.1038/s41598-023-36043-1 [doi]
LID - 9322
AB  - Bisphenol A (BPA) is a plasticiser used in the manufacturing of many products and 
      its effects on human health remain controversial. Up till now, BPA involvement in 
      metabolic syndrome risk and development is still not fully understood. In this 
      study, we aimed to investigate the effect of prenatal BPA exposure with postnatal 
      trans-fat diet intake on metabolic parameters and pancreatic tissue histology. 
      Eighteen pregnant rats were divided into control (CTL), vehicle tween 80 (VHC), 
      and BPA (5 mg/kg/day) from gestational day (GD) 2 until GD 21, then their weaning 
      rat's offspring were fed with normal diet (ND) or trans-fat diet (TFD) from 
      postnatal week (PNW) 3 until PNW 14. The rats were then sacrificed and the blood 
      (biochemical analysis) and pancreatic tissues (histological analysis) were 
      collected. Glucose, insulin, and lipid profile were measured. The study has shown 
      that there was no significant difference between groups with regard to glucose, 
      insulin, and lipid profiles (p > 0.05). All pancreatic tissues showed normal 
      architecture with irregular islets of Langerhans in TFD intake groups compared to 
      offspring that consumed ND. Furthermore, the pancreatic histomorphometry was also 
      affected whereby the study findings revealed that there was a significant 
      increase in the mean number of pancreatic islets in rats from BPA-TFD group 
      (5.987 +/- 0.3159 islets/field, p = 0.0022) compared to those fed with ND and BPA 
      non-exposed. In addition, the results have found that prenatal BPA exposure 
      resulted in a significant decrease in the pancreatic islets diameter of the 
      BPA-ND group (183.3 +/- 23.28 microm, p = 0.0022) compared to all other groups. In 
      conclusion, prenatal BPA exposure with postnatal TFD in the offspring may affect 
      glucose homeostasis and pancreatic islets in adulthood, and the effect may be 
      more aggravated in late adulthood.
CI  - (c) 2023. The Author(s).
FAU - Abulehia, Hala
AU  - Abulehia H
AD  - Institute of Medical Molecular Biotechnology (IMMB), Faculty of Medicine, 
      Universiti Teknologi MARA (UiTM), Cawangan Selangor, Kampus Sungai Buloh, Jalan 
      Hospital, 47000, Sungai Buloh, Malaysia.
FAU - Mohd Nor, Noor Shafina
AU  - Mohd Nor NS
AD  - Institute of Medical Molecular Biotechnology (IMMB), Faculty of Medicine, 
      Universiti Teknologi MARA (UiTM), Cawangan Selangor, Kampus Sungai Buloh, Jalan 
      Hospital, 47000, Sungai Buloh, Malaysia. drshafina@uitm.edu.my.
AD  - Department of Paediatrics, Faculty of Medicine, Universiti Teknologi MARA (UiTM), 
      Cawangan Selangor, Kampus Sungai Buloh, Jalan Hospital, 47000, Sungai Buloh, 
      Malaysia. drshafina@uitm.edu.my.
AD  - Institute for Pathology, Laboratory and Forensic Medicine (I-PPerForM), 
      Universiti Teknologi MARA (UiTM), Cawangan Selangor, Kampus Sungai Buloh, Jalan 
      Hospital, 47000, Sungai Buloh, Malaysia. drshafina@uitm.edu.my.
FAU - Sheikh Abdul Kadir, Siti Hamimah
AU  - Sheikh Abdul Kadir SH
AD  - Institute of Medical Molecular Biotechnology (IMMB), Faculty of Medicine, 
      Universiti Teknologi MARA (UiTM), Cawangan Selangor, Kampus Sungai Buloh, Jalan 
      Hospital, 47000, Sungai Buloh, Malaysia.
AD  - Institute for Pathology, Laboratory and Forensic Medicine (I-PPerForM), 
      Universiti Teknologi MARA (UiTM), Cawangan Selangor, Kampus Sungai Buloh, Jalan 
      Hospital, 47000, Sungai Buloh, Malaysia.
AD  - Department of Biochemistry and Molecular Medicine, Faculty of Medicine, 
      Universiti Teknologi MARA (UiTM), Cawangan Selangor, Kampus Sungai Buloh, Jalan 
      Hospital, 47000, Sungai Buloh, Malaysia.
FAU - Abdul Aziz, Mardiana
AU  - Abdul Aziz M
AD  - Department of Pathology, Faculty of Medicine, Universiti Teknologi MARA (UiTM), 
      Cawangan Selangor, Kampus Sungai Buloh, Jalan Hospital, Sungai Buloh, 47000, 
      Selangor, Malaysia.
FAU - Zulkifli, Sarah
AU  - Zulkifli S
AD  - Institute for Pathology, Laboratory and Forensic Medicine (I-PPerForM), 
      Universiti Teknologi MARA (UiTM), Cawangan Selangor, Kampus Sungai Buloh, Jalan 
      Hospital, 47000, Sungai Buloh, Malaysia.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20230608
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - MLT3645I99 (bisphenol A)
RN  - 0 (Benzhydryl Compounds)
RN  - 0 (Insulin)
RN  - IY9XDZ35W2 (Glucose)
RN  - 0 (Lipids)
SB  - IM
MH  - Humans
MH  - Female
MH  - Pregnancy
MH  - Rats
MH  - Animals
MH  - *Benzhydryl Compounds/toxicity
MH  - Insulin
MH  - Glucose/metabolism
MH  - Diet
MH  - Lipids
MH  - *Prenatal Exposure Delayed Effects/pathology
PMC - PMC10250527
COIS- The authors declare no competing interests.
EDAT- 2023/06/09 01:09
MHDA- 2023/06/12 06:43
PMCR- 2023/06/08
CRDT- 2023/06/08 23:19
PHST- 2022/12/02 00:00 [received]
PHST- 2023/05/28 00:00 [accepted]
PHST- 2023/06/12 06:43 [medline]
PHST- 2023/06/09 01:09 [pubmed]
PHST- 2023/06/08 23:19 [entrez]
PHST- 2023/06/08 00:00 [pmc-release]
AID - 10.1038/s41598-023-36043-1 [pii]
AID - 36043 [pii]
AID - 10.1038/s41598-023-36043-1 [doi]
PST - epublish
SO  - Sci Rep. 2023 Jun 8;13(1):9322. doi: 10.1038/s41598-023-36043-1.