PMID- 37291477 OWN - NLM STAT- MEDLINE DCOM- 20231004 LR - 20231004 IS - 1995-8218 (Electronic) IS - 1673-7067 (Print) IS - 1995-8218 (Linking) VI - 39 IP - 10 DP - 2023 Oct TI - Compound from Magnolia officinalis Ameliorates White Matter Injury by Promoting Oligodendrocyte Maturation in Chronic Cerebral Ischemia Models. PG - 1497-1511 LID - 10.1007/s12264-023-01068-z [doi] AB - Chronic cerebral hypoperfusion leads to white matter injury (WMI), which subsequently causes neurodegeneration and even cognitive impairment. However, due to the lack of treatment specifically for WMI, novel recognized and effective therapeutic strategies are urgently needed. In this study, we found that honokiol and magnolol, two compounds derived from Magnolia officinalis, significantly facilitated the differentiation of primary oligodendrocyte precursor cells (OPCs) into mature oligodendrocytes, with a more prominent effect of the former compound. Moreover, our results demonstrated that honokiol treatment improved myelin injury, induced mature oligodendrocyte protein expression, attenuated cognitive decline, promoted oligodendrocyte regeneration, and inhibited astrocytic activation in the bilateral carotid artery stenosis model. Mechanistically, honokiol increased the phosphorylation of serine/threonine kinase (Akt) and mammalian target of rapamycin (mTOR) by activating cannabinoid receptor 1 during OPC differentiation. Collectively, our study indicates that honokiol might serve as a potential treatment for WMI in chronic cerebral ischemia. CI - (c) 2023. The Author(s). FAU - Zhang, Zhi AU - Zhang Z AD - Department of Neurology, Nanjing Drum Tower Hospital Clinical College of Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, 210008, China. AD - Department of Neurology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School and State Key Laboratory of Pharmaceutical Biotechnology and Institute of Translational Medicine for Brain Critical Diseases, Nanjing University, Nanjing, 210008, China. FAU - Shu, Xin AU - Shu X AD - Department of Neurology, Nanjing Drum Tower Hospital Clinical College of Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, 210008, China. AD - Department of Neurology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School and State Key Laboratory of Pharmaceutical Biotechnology and Institute of Translational Medicine for Brain Critical Diseases, Nanjing University, Nanjing, 210008, China. FAU - Cao, Qian AU - Cao Q AD - Department of Neurology, Nanjing Drum Tower Hospital Clinical College of Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, 210008, China. AD - Department of Neurology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School and State Key Laboratory of Pharmaceutical Biotechnology and Institute of Translational Medicine for Brain Critical Diseases, Nanjing University, Nanjing, 210008, China. FAU - Xu, Lushan AU - Xu L AD - Department of Neurology, Nanjing Drum Tower Hospital Clinical College of Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, 210008, China. AD - Department of Neurology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School and State Key Laboratory of Pharmaceutical Biotechnology and Institute of Translational Medicine for Brain Critical Diseases, Nanjing University, Nanjing, 210008, China. FAU - Wang, Zibu AU - Wang Z AD - Department of Neurology, Nanjing Drum Tower Hospital Clinical College of Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, 210008, China. AD - Department of Neurology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School and State Key Laboratory of Pharmaceutical Biotechnology and Institute of Translational Medicine for Brain Critical Diseases, Nanjing University, Nanjing, 210008, China. FAU - Li, Chenggang AU - Li C AD - Department of Neurology, Nanjing Drum Tower Hospital Clinical College of Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, 210008, China. AD - Department of Neurology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School and State Key Laboratory of Pharmaceutical Biotechnology and Institute of Translational Medicine for Brain Critical Diseases, Nanjing University, Nanjing, 210008, China. FAU - Xia, Shengnan AU - Xia S AD - Department of Neurology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School and State Key Laboratory of Pharmaceutical Biotechnology and Institute of Translational Medicine for Brain Critical Diseases, Nanjing University, Nanjing, 210008, China. AD - Jiangsu Key Laboratory for Molecular Medicine, Medical School of Nanjing University, Nanjing, 210008, China. FAU - Shao, Pengfei AU - Shao P AD - Department of Neurology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School and State Key Laboratory of Pharmaceutical Biotechnology and Institute of Translational Medicine for Brain Critical Diseases, Nanjing University, Nanjing, 210008, China. AD - Jiangsu Key Laboratory for Molecular Medicine, Medical School of Nanjing University, Nanjing, 210008, China. FAU - Bao, Xinyu AU - Bao X AD - Department of Neurology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School and State Key Laboratory of Pharmaceutical Biotechnology and Institute of Translational Medicine for Brain Critical Diseases, Nanjing University, Nanjing, 210008, China. AD - Jiangsu Key Laboratory for Molecular Medicine, Medical School of Nanjing University, Nanjing, 210008, China. FAU - Sun, Liang AU - Sun L AD - Department of Neurology, Nanjing Drum Tower Hospital Clinical College of Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, 210008, China. AD - Department of Neurology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School and State Key Laboratory of Pharmaceutical Biotechnology and Institute of Translational Medicine for Brain Critical Diseases, Nanjing University, Nanjing, 210008, China. FAU - Xu, Yuhao AU - Xu Y AD - Department of Neurology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School and State Key Laboratory of Pharmaceutical Biotechnology and Institute of Translational Medicine for Brain Critical Diseases, Nanjing University, Nanjing, 210008, China. AD - Jiangsu Key Laboratory for Molecular Medicine, Medical School of Nanjing University, Nanjing, 210008, China. FAU - Xu, Yun AU - Xu Y AUID- ORCID: 0000-0001-5288-0319 AD - Department of Neurology, Nanjing Drum Tower Hospital Clinical College of Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, 210008, China. xuyun20042001@aliyun.com. AD - Department of Neurology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School and State Key Laboratory of Pharmaceutical Biotechnology and Institute of Translational Medicine for Brain Critical Diseases, Nanjing University, Nanjing, 210008, China. xuyun20042001@aliyun.com. AD - Jiangsu Key Laboratory for Molecular Medicine, Medical School of Nanjing University, Nanjing, 210008, China. xuyun20042001@aliyun.com. AD - Jiangsu Provincial Key Discipline of Neurology, Nanjing, 210008, China. xuyun20042001@aliyun.com. AD - Nanjing Neurology Medical Center, Nanjing, 210008, China. xuyun20042001@aliyun.com. LA - eng PT - Journal Article DEP - 20230609 PL - Singapore TA - Neurosci Bull JT - Neuroscience bulletin JID - 101256850 RN - 11513CCO0N (honokiol) SB - IM MH - *Magnolia MH - *White Matter MH - *Brain Ischemia/drug therapy/metabolism MH - Oligodendroglia/metabolism PMC - PMC10533772 OTO - NOTNLM OT - Honokiol OT - Oligodendrocyte OT - Vascular dementia OT - White matter injury COIS- The authors declare that they have no conflicts of interest in this work. EDAT- 2023/06/09 01:09 MHDA- 2023/10/04 06:43 PMCR- 2023/06/09 CRDT- 2023/06/08 23:35 PHST- 2022/08/17 00:00 [received] PHST- 2023/02/20 00:00 [accepted] PHST- 2023/10/04 06:43 [medline] PHST- 2023/06/09 01:09 [pubmed] PHST- 2023/06/08 23:35 [entrez] PHST- 2023/06/09 00:00 [pmc-release] AID - 10.1007/s12264-023-01068-z [pii] AID - 1068 [pii] AID - 10.1007/s12264-023-01068-z [doi] PST - ppublish SO - Neurosci Bull. 2023 Oct;39(10):1497-1511. doi: 10.1007/s12264-023-01068-z. Epub 2023 Jun 9.