PMID- 37292102 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20230611 IS - 2398-8835 (Electronic) IS - 2398-8835 (Linking) VI - 6 IP - 6 DP - 2023 Jun TI - Quality of glycemic control in type 2 diabetes mellitus (T2DM) and its association with markers of coagulation and inhibitors of fibrinolysis: A case-control study in the Upper West Region, Ghana. PG - e1297 LID - 10.1002/hsr2.1297 [doi] LID - e1297 AB - BACKGROUND AND AIMS: Type 2 diabetes mellitus (T2DM) individuals are at a higher risk of developing diabetes complications, with approximately 80% complication-related mortality. The increased morbidity and mortality among T2DM patients are partly due to dysregulated hemostasis. This study determined the quality of glycemic control in T2DM and its association with markers of coagulation and inhibitors of fibrinolysis. METHODS: This case-control study recruited 90 participants involving: 30 T2DM patients with good glycemic control, 30 with poor glycemic control, and 30 nondiabetic subjects as controls at a Municipal Hospital in Ghana. Fasting blood glucose, glycated hemoglobin, activated partial thromboplastin time (APTT), prothrombin time (PT), calculated international normalized ratio (INR), and full blood count (FBC) were determined for each respondent. Plasma levels of plasminogen activator inhibitor-1 (PAI-1) and thrombin activatable fibrinolysis inhibitor (TAFI) were determined using the solid-phase sandwich enzyme-linked immunosorbent assay method. Data were analyzed using R language software. RESULTS: Plasma PAI-1 antigen levels were significantly higher in the participants with poor glycemic control as compared to participants with good glycemic control (p < 0.0001). There was no significant difference in plasma TAFI levels between the participants with poor glycemic control as compared to participants with good glycemic control (p = 0.900). T2DM patients had significantly shorter APTT, PT, and INR than controls (p < 0.05). At a cut-off of >/=161.70 pg/muL, PAI was independently associated with increasing odds (adjusted odds ratio = 13.71, 95% confidence interval: 3.67-51.26, p < 0.0001) of poor glycemic control and showed the best diagnostic accuracy for poor glycemic control (area under the curve = 0.85, p < 0.0001). CONCLUSION: PAI-1 levels were significantly increased in T2DM with poor glycemic control and emerged as the best predictor for poor glycemic control. Good glycemic management to control the plasma levels of PAI-1 is required to prevent hypercoagulability and thrombotic disorders. CI - (c) 2023 The Authors. Health Science Reports published by Wiley Periodicals LLC. FAU - Selleh, Peter K AU - Selleh PK AD - Department of Medical Diagnostics, Faculty of Allied Health Sciences, College of Health Sciences Kwame Nkrumah University of Science and Technology Kumasi Ghana. FAU - Anto, Enoch O AU - Anto EO AUID- ORCID: 0000-0001-9023-6612 AD - Department of Medical Diagnostics, Faculty of Allied Health Sciences, College of Health Sciences Kwame Nkrumah University of Science and Technology Kumasi Ghana. AD - School of Medical and Health Sciences Edith Cowan University Joondalup Western Australia Australia. AD - Centre for Precision Health, ECU Strategic Research Centre Edith Cowan University Joondalup Western Australia Australia. FAU - Boadu, Wina I O AU - Boadu WIO AUID- ORCID: 0000-0002-2660-1707 AD - Department of Medical Diagnostics, Faculty of Allied Health Sciences, College of Health Sciences Kwame Nkrumah University of Science and Technology Kumasi Ghana. FAU - Sackey, Benedict AU - Sackey B AD - Department of Medical Diagnostics, Faculty of Allied Health Sciences, College of Health Sciences Kwame Nkrumah University of Science and Technology Kumasi Ghana. FAU - Boateng, Lilian A AU - Boateng LA AD - Department of Medical Diagnostics, Faculty of Allied Health Sciences, College of Health Sciences Kwame Nkrumah University of Science and Technology Kumasi Ghana. FAU - Nkansah, Charles AU - Nkansah C AUID- ORCID: 0000-0001-6986-9976 AD - Department of Medical Diagnostics, Faculty of Allied Health Sciences, College of Health Sciences Kwame Nkrumah University of Science and Technology Kumasi Ghana. FAU - Nsafoah, Frederick AU - Nsafoah F AD - Department of Medical Diagnostics, Faculty of Allied Health Sciences, College of Health Sciences Kwame Nkrumah University of Science and Technology Kumasi Ghana. FAU - Saasi, Abdul R AU - Saasi AR AD - Department of Medical Diagnostics, Faculty of Allied Health Sciences, College of Health Sciences Kwame Nkrumah University of Science and Technology Kumasi Ghana. FAU - Mintaah, Selina AU - Mintaah S AD - Department of Medical Diagnostics, Faculty of Allied Health Sciences, College of Health Sciences Kwame Nkrumah University of Science and Technology Kumasi Ghana. FAU - Wiafe, Yaw A AU - Wiafe YA AD - Department of Medical Diagnostics, Faculty of Allied Health Sciences, College of Health Sciences Kwame Nkrumah University of Science and Technology Kumasi Ghana. FAU - Derigubah, Charles AU - Derigubah C AD - Department of Medical Diagnostics, Faculty of Allied Health Sciences, College of Health Sciences Kwame Nkrumah University of Science and Technology Kumasi Ghana. FAU - Korsah, Emmanuel E AU - Korsah EE AD - Department of Medical Diagnostics, Faculty of Allied Health Sciences, College of Health Sciences Kwame Nkrumah University of Science and Technology Kumasi Ghana. FAU - Frimpong, Joseph AU - Frimpong J AUID- ORCID: 0000-0002-9128-7208 AD - Department of Medical Diagnostics, Faculty of Allied Health Sciences, College of Health Sciences Kwame Nkrumah University of Science and Technology Kumasi Ghana. FAU - Ansah, Ezekiel AU - Ansah E AD - Department of Medical Diagnostics, Faculty of Allied Health Sciences, College of Health Sciences Kwame Nkrumah University of Science and Technology Kumasi Ghana. FAU - Tamakloe, Valentine C K T AU - Tamakloe VCKT AUID- ORCID: 0000-0002-2411-6441 AD - Department of Medical Diagnostics, Faculty of Allied Health Sciences, College of Health Sciences Kwame Nkrumah University of Science and Technology Kumasi Ghana. FAU - Adu, Patrick AU - Adu P AD - Department of Medical Laboratory Science, School of Allied Health Sciences University of Cape Coast Cape Coast Ghana. FAU - Boachie, Joseph AU - Boachie J AD - Department of Medical Laboratory Science, School of Allied Health Sciences University of Cape Coast Cape Coast Ghana. FAU - Addai-Mensah, Otchere AU - Addai-Mensah O AUID- ORCID: 0000-0001-9225-5876 AD - Department of Medical Diagnostics, Faculty of Allied Health Sciences, College of Health Sciences Kwame Nkrumah University of Science and Technology Kumasi Ghana. LA - eng PT - Journal Article DEP - 20230607 PL - United States TA - Health Sci Rep JT - Health science reports JID - 101728855 PMC - PMC10246457 OTO - NOTNLM OT - coagulation OT - glycemic control OT - plasminogen activator inhibitor OT - thrombin activatable fibrinolysis inhibitor OT - type 2 diabetes mellitus COIS- The authors declare no conflict of interest. EDAT- 2023/06/09 06:42 MHDA- 2023/06/09 06:43 PMCR- 2023/06/07 CRDT- 2023/06/09 04:16 PHST- 2023/03/15 00:00 [received] PHST- 2023/04/17 00:00 [revised] PHST- 2023/04/18 00:00 [accepted] PHST- 2023/06/09 06:43 [medline] PHST- 2023/06/09 06:42 [pubmed] PHST- 2023/06/09 04:16 [entrez] PHST- 2023/06/07 00:00 [pmc-release] AID - HSR21297 [pii] AID - 10.1002/hsr2.1297 [doi] PST - epublish SO - Health Sci Rep. 2023 Jun 7;6(6):e1297. doi: 10.1002/hsr2.1297. eCollection 2023 Jun.