PMID- 37292743
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240215
DP  - 2023 May 26
TI  - Type-2 diabetes alters hippocampal neural oscillations and disrupts synchrony 
      between hippocampus and cortex.
LID - 2023.05.25.542288 [pii]
LID - 10.1101/2023.05.25.542288 [doi]
AB  - Type 2 diabetes mellitus (T2DM) increases the risk of neurological diseases, yet 
      how brain oscillations change as age and T2DM interact is not well characterized. 
      To delineate the age and diabetic effect on neurophysiology, we recorded local 
      field potentials with multichannel electrodes spanning the somatosensory cortex 
      and hippocampus (HPC) under urethane anesthesia in diabetic and normoglycemic 
      control mice, at 200 and 400 days of age. We analyzed the signal power of brain 
      oscillations, brain state, sharp wave associate ripples (SPW-Rs), and functional 
      connectivity between the cortex and HPC. We found that while both age and T2DM 
      were correlated with a breakdown in long-range functional connectivity and 
      reduced neurogenesis in the dentate gyrus and subventricular zone, T2DM further 
      slowed brain oscillations and reduced theta-gamma coupling. Age and T2DM also 
      prolonged the duration of SPW-Rs and increased gamma power during SPW-R phase. 
      Our results have identified potential electrophysiological substrates of 
      hippocampal changes associated with T2DM and age. The perturbed brain oscillation 
      features and diminished neurogenesis may underlie T2DM-accelerated cognitive 
      impairment.
FAU - Rabiller, Gratianne
AU  - Rabiller G
FAU - Ip, Zachary
AU  - Ip Z
AUID- ORCID: 0000-0002-4542-8479
FAU - Zarrabian, Shahram
AU  - Zarrabian S
AUID- ORCID: 0000-0001-9022-4806
FAU - Zhang, Hongxia
AU  - Zhang H
AUID- ORCID: 0000-0003-1594-6707
FAU - Sato, Yoshimichi
AU  - Sato Y
FAU - Yazdan-Shahmorad, Azadeh
AU  - Yazdan-Shahmorad A
AUID- ORCID: 0000-0001-5212-509X
FAU - Liu, Jialing
AU  - Liu J
LA  - eng
GR  - I01 BX003335/BX/BLRD VA/United States
GR  - IK6 BX004600/BX/BLRD VA/United States
GR  - IS1 BX005033/BX/BLRD VA/United States
GR  - R21 NS120193/NS/NINDS NIH HHS/United States
PT  - Preprint
DEP - 20230526
PL  - United States
TA  - bioRxiv
JT  - bioRxiv : the preprint server for biology
JID - 101680187
UIN - Aging Dis. 2023 Nov 15;:. PMID: 38029397
PMC - PMC10245872
EDAT- 2023/06/09 06:42
MHDA- 2023/06/09 06:43
PMCR- 2023/06/07
CRDT- 2023/06/09 04:26
PHST- 2023/06/09 06:43 [medline]
PHST- 2023/06/09 06:42 [pubmed]
PHST- 2023/06/09 04:26 [entrez]
PHST- 2023/06/07 00:00 [pmc-release]
AID - 2023.05.25.542288 [pii]
AID - 10.1101/2023.05.25.542288 [doi]
PST - epublish
SO  - bioRxiv [Preprint]. 2023 May 26:2023.05.25.542288. doi: 
      10.1101/2023.05.25.542288.