PMID- 37293307
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230612
IS  - 2296-858X (Print)
IS  - 2296-858X (Electronic)
IS  - 2296-858X (Linking)
VI  - 10
DP  - 2023
TI  - Improved clinical outcomes in response to a 12-week blended digital and 
      community-based long-COVID-19 rehabilitation programme.
PG  - 1149922
LID - 10.3389/fmed.2023.1149922 [doi]
LID - 1149922
AB  - INTRODUCTION: Two million people in the UK are experiencing long COVID (LC), 
      which necessitates effective and scalable interventions to manage this condition. 
      This study provides the first results from a scalable rehabilitation programme 
      for participants presenting with LC. METHODS: 601 adult participants with 
      symptoms of LC completed the Nuffield Health COVID-19 Rehabilitation Programme 
      between February 2021 and March 2022 and provided written informed consent for 
      the inclusion of outcomes data in external publications. The 12-week programme 
      included three exercise sessions per week consisting of aerobic and 
      strength-based exercises, and stability and mobility activities. The first 6 
      weeks of the programme were conducted remotely, whereas the second 6 weeks 
      incorporated face-to-face rehabilitation sessions in a community setting. A 
      weekly telephone call with a rehabilitation specialist was also provided to 
      support queries and advise on exercise selection, symptom management and 
      emotional wellbeing. RESULTS: The 12-week rehabilitation programme significantly 
      improved Dyspnea-12 (D-12), Duke Activity Status Index (DASI), World Health 
      Orginaisation-5 (WHO-5) and EQ-5D-5L utility scores (all p < 0.001), with the 95% 
      confidence intervals (CI) for the improvement in each of these outcomes exceeding 
      the minimum clinically important difference (MCID) for each measure (mean change 
      [CI]: D-12: -3.4 [-3.9, -2.9]; DASI: 9.2 [8.2, 10.1]; WHO-5: 20.3 [18.6, 22.0]; 
      EQ-5D-5L utility: 0.11 [0.10, 0.13]). Significant improvements exceeding the MCID 
      were also observed for sit-to-stand test results (4.1 [3.5, 4.6]). On completion 
      of the rehabilitation programme, participants also reported significantly fewer 
      GP consultations (p < 0.001), sick days (p = 0.003) and outpatient visits (p = 
      0.007) during the previous 3 months compared with baseline. DISCUSSION: The 
      blended and community design of this rehabilitation model makes it scalable and 
      meets the urgent need for an effective intervention to support patients 
      experiencing LC. This rehabilitation model is well placed to support the NHS (and 
      other healthcare systems worldwide) in its aim of controlling the impacts of 
      COVID-19 and delivering on its long-term plan. CLINICAL TRIAL REGISTRATION: 
      https://www.isrctn.com/ISRCTN14707226, identifier 14707226.
CI  - Copyright (c) 2023 Smith, Deighton, Innes, Holl, Mould, Liao, Doherty, Whyte, King, 
      Deniszczyc and Kelly.
FAU - Smith, Jemma L
AU  - Smith JL
AD  - Nuffield Health, Epsom, United Kingdom.
FAU - Deighton, Kevin
AU  - Deighton K
AD  - Nuffield Health, Epsom, United Kingdom.
FAU - Innes, Aidan Q
AU  - Innes AQ
AD  - Nuffield Health, Epsom, United Kingdom.
FAU - Holl, Marc
AU  - Holl M
AD  - Nuffield Health, Epsom, United Kingdom.
FAU - Mould, Laura
AU  - Mould L
AD  - Nuffield Health, Epsom, United Kingdom.
FAU - Liao, Zhining
AU  - Liao Z
AD  - Nuffield Health, Epsom, United Kingdom.
FAU - Doherty, Patrick
AU  - Doherty P
AD  - Department of Health Sciences, University of York, York, United Kingdom.
FAU - Whyte, Greg
AU  - Whyte G
AD  - School of Sport and Exercise Sciences, Liverpool John Moores University, 
      Liverpool, United Kingdom.
FAU - King, James A
AU  - King JA
AD  - National Centre for Sport and Exercise Medicine, Loughborough University, 
      Loughborough, United Kingdom.
AD  - NIHR Leicester Biomedical Research Centre, University Hospitals of Leicester NHS 
      Trust, University of Leicester, Leicester, United Kingdom.
FAU - Deniszczyc, Davina
AU  - Deniszczyc D
AD  - Nuffield Health, Epsom, United Kingdom.
FAU - Kelly, Benjamin M
AU  - Kelly BM
AD  - Nuffield Health, Epsom, United Kingdom.
AD  - Department of Health Professions, Faculty of Health and Education, Manchester 
      Metropolitan University, Manchester, United Kingdom.
LA  - eng
PT  - Journal Article
DEP - 20230524
PL  - Switzerland
TA  - Front Med (Lausanne)
JT  - Frontiers in medicine
JID - 101648047
PMC - PMC10244528
OTO - NOTNLM
OT  - SARS-CoV-2
OT  - SeaCole
OT  - coronavirus
OT  - digital health
OT  - emotional wellbeing
OT  - exercise
OT  - fatigue
COIS- JS, KD, AI, MH, LM, ZL, DD, and BK were employed by Nuffield Health. The 
      remaining authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2023/06/09 06:42
MHDA- 2023/06/09 06:43
PMCR- 2023/05/24
CRDT- 2023/06/09 04:33
PHST- 2023/01/30 00:00 [received]
PHST- 2023/05/02 00:00 [accepted]
PHST- 2023/06/09 06:43 [medline]
PHST- 2023/06/09 06:42 [pubmed]
PHST- 2023/06/09 04:33 [entrez]
PHST- 2023/05/24 00:00 [pmc-release]
AID - 10.3389/fmed.2023.1149922 [doi]
PST - epublish
SO  - Front Med (Lausanne). 2023 May 24;10:1149922. doi: 10.3389/fmed.2023.1149922. 
      eCollection 2023.