PMID- 37293481
OWN - NLM
STAT- MEDLINE
DCOM- 20230612
LR  - 20240227
IS  - 1664-2392 (Print)
IS  - 1664-2392 (Electronic)
IS  - 1664-2392 (Linking)
VI  - 14
DP  - 2023
TI  - Analysis of retinal and choroidal characteristics in patients with early diabetic 
      retinopathy using WSS-OCTA.
PG  - 1184717
LID - 10.3389/fendo.2023.1184717 [doi]
LID - 1184717
AB  - INTRODUCTION: Diabetic retinopathy (DR) is one of the most common and destructive 
      microvascular complications of DM, and has become a major cause of irreversible 
      visual impairment. The purpose of this study was to evaluate the changes in 
      fundus microcirculation in non-diabetic retinopathy (NDR) and mild 
      non-proliferative diabetic retinopathy (NPDR) in patients with type 2 diabetic 
      mellitus (T2DM) using widefield swept-source optical coherence tomography 
      angiography (WSSOCTA), and to investigate the correlation with laboratory indices 
      of T2DM. METHODS: Eighty nine, 58 and 28 eyes were included in the NDR, NPDR and 
      Control groups, respectively, were enrolled in this study. The 12mmx12mm fundus 
      images obtained by WSS-OCTA were divided into 9 regions (supratemporal, ST; 
      temporal, T; inferotemporal, IT; superior, S; central macular area, C; inferior, 
      I; supranasal, SN; nasal, N; inferonasal, IN) to evaluate changes in vessel 
      density (VD) of the superficial capillary plexus (SCP), deep capillary plexus 
      (DCP), choriocapillaris, and mid-large choroidal vessel (MLCV), as well as 
      changes in inner retinal thickness (IRT), outer retinal thickness (ORT), and 
      choroidal thickness (CT). Results: Compared with control group, MLCV VD (I, N, 
      IN) was significantly decreased in NDR group, SCP VD (IT, C, I) and DCP VD (T, 
      IT, I) were significantly decreased in NPDR group. In NPDR group, DCP VD (IT) was 
      significantly decreased compared with that in NDR group. Compared with control 
      group, CT (ST, T, IT, S, SN, IN) was significantly declined in NDR group, and IRT 
      (ST, IT) and ORT (ST, N) were significantly increased in NPDR group. In NPDR 
      group, IRT (ST) and ORT (T, S) were significantly increased compared with NDR 
      group. Correlation analysis showed that age, body mass index, fasting blood 
      glucose, fasting insulin, fasting C-peptide, and estimated glomerular filtration 
      rate in T2DM patients were statistically correlated with retinal and choroidal 
      thickness/VD. DISCUSSION: Structural and blood flow changes in the choroid occur 
      before the onset of DR and precede changes in the retinal microcirculation, and 
      MLCV thickness/VD is a more sensitive imaging biomarker for the clinical 
      detection of DR. WSS-OCTA enables large-scale non-invasive visual screening and 
      follow-up of the retinal and choroidal vasculature in DR patients, providing a 
      new strategy for the prevention and monitoring of DR in patients with T2DM.
CI  - Copyright (c) 2023 Qi, Si, Feng, Zhu, Yang, Wang, Zhang and Cui.
FAU - Qi, Zhihao
AU  - Qi Z
AD  - Department of Ophthalmology, Qilu Hospital of Shandong University, Jinan, China.
AD  - Cheeloo College of Medicine, Shandong University, Jinan, China.
FAU - Si, Yuanyuan
AU  - Si Y
AD  - Department of Ophthalmology, Qilu Hospital of Shandong University, Jinan, China.
AD  - Cheeloo College of Medicine, Shandong University, Jinan, China.
FAU - Feng, Feng
AU  - Feng F
AD  - Cheeloo College of Medicine, Shandong University, Jinan, China.
AD  - Department of Nephrology, Qilu Hospital of Shandong University, Jinan, China.
FAU - Zhu, Jing
AU  - Zhu J
AD  - Department of Ophthalmology, Qilu Hospital of Shandong University, Jinan, China.
FAU - Yang, Xuepeng
AU  - Yang X
AD  - Department of Ophthalmology, Qilu Hospital of Shandong University, Jinan, China.
AD  - Cheeloo College of Medicine, Shandong University, Jinan, China.
FAU - Wang, Wenjuan
AU  - Wang W
AD  - Department of Ophthalmology, Qilu Hospital of Shandong University, Jinan, China.
FAU - Zhang, Yuting
AU  - Zhang Y
AD  - Department of Ophthalmology, Qilu Hospital of Shandong University, Jinan, China.
FAU - Cui, Yan
AU  - Cui Y
AD  - Department of Ophthalmology, Qilu Hospital of Shandong University, Jinan, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20230524
PL  - Switzerland
TA  - Front Endocrinol (Lausanne)
JT  - Frontiers in endocrinology
JID - 101555782
SB  - IM
MH  - Humans
MH  - Fluorescein Angiography/methods
MH  - Retinal Vessels/diagnostic imaging
MH  - Retina/diagnostic imaging
MH  - *Diabetic Retinopathy/diagnosis
MH  - Choroid/diagnostic imaging/blood supply
MH  - *Diabetes Mellitus, Type 2
PMC - PMC10244727
OTO - NOTNLM
OT  - early-diabetic retinopathy
OT  - mid-large choroidal vessel
OT  - midperipheral fundus
OT  - physiological indices
OT  - type 2 diabetes mellitus
OT  - widefield swept-source optical coherence tomography angiography
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2023/06/09 06:42
MHDA- 2023/06/12 06:42
PMCR- 2023/01/01
CRDT- 2023/06/09 04:36
PHST- 2023/03/12 00:00 [received]
PHST- 2023/05/11 00:00 [accepted]
PHST- 2023/06/12 06:42 [medline]
PHST- 2023/06/09 06:42 [pubmed]
PHST- 2023/06/09 04:36 [entrez]
PHST- 2023/01/01 00:00 [pmc-release]
AID - 10.3389/fendo.2023.1184717 [doi]
PST - epublish
SO  - Front Endocrinol (Lausanne). 2023 May 24;14:1184717. doi: 
      10.3389/fendo.2023.1184717. eCollection 2023.