PMID- 37294688
OWN - NLM
STAT- MEDLINE
DCOM- 20240207
LR  - 20240228
IS  - 1399-3046 (Electronic)
IS  - 1397-3142 (Linking)
VI  - 28
IP  - 1
DP  - 2024 Feb
TI  - Outcomes of pediatric deceased donor kidney transplant in northeast Thailand.
PG  - e14411
LID - 10.1111/petr.14411 [doi]
AB  - BACKGROUND: Kidney transplantation (KT) is the best therapy in children with 
      end-stage renal disease (ESRD), however, improving long-term graft survival 
      remains challenging. The aim of this study was to determine graft survival and 
      potential risk factors in pediatric patients who undergo deceased donor KT with a 
      steroid-based regimen. METHODS: The medical records of children who underwent 
      their first deceased donor KT in Srinagarind Hospital (Khon Kaen, Thailand) 
      between 2001 and 2020 were reviewed. RESULTS: Seventy-two patients were studied. 
      Male adolescents were the predominant recipients and the majority of donors were 
      young adult males. Non-glomerular disease, particularly hypoplastic/dysplastic 
      kidney disease, was the major cause of ESRD (48.61%). The mean cold ischemic time 
      (CIT) was 18.29 +/- 5.29 h. Most of the recipients had more than 4 human leukocyte 
      antigen (HLA) mismatched loci with positive HLA-DR mismatch (52.78%). Induction 
      therapy was administered in 76.74% of recipients. Tacrolimus plus mycophenolate 
      sodium and prednisolone was the most common immunosuppressive maintenance regimen 
      (69.44%). Graft failure occurred in 18 patients, mostly due to graft rejection 
      (50%). Graft survival at 1, 3, and 5 years after KT were 94.40%, 86.25%, and 
      74.92%, respectively. The only significant risk factor of graft failure in this 
      study was delayed graft function (DGF) (adjusted HR = 3.55; 95%CI: 1.14, 11.12; 
      p = .029). Patient survival at 1, 3, and 5 years was 100%, 98.48%, and 96.19%, 
      respectively. CONCLUSION: The short-term outcomes of pediatric KT from deceased 
      donors were satisfactory; however, prevention of DGF would result in better 
      outcomes.
CI  - (c) 2023 Wiley Periodicals LLC.
FAU - Ratviset, Preeyapat
AU  - Ratviset P
AD  - Department of Pediatrics, Faculty of Medicine, Khon Kaen University, Khon Kaen, 
      Thailand.
FAU - Panombualert, Sunee
AU  - Panombualert S
AD  - Department of Pediatrics, Faculty of Medicine, Khon Kaen University, Khon Kaen, 
      Thailand.
FAU - Chathum, Kannika
AU  - Chathum K
AD  - Outpatient Department, Faculty of Medicine, Khon Kaen University, Khon Kaen, 
      Thailand.
FAU - Wisanuyotin, Suwannee
AU  - Wisanuyotin S
AUID- ORCID: 0000-0001-7181-0092
AD  - Department of Pediatrics, Faculty of Medicine, Khon Kaen University, Khon Kaen, 
      Thailand.
LA  - eng
GR  - IN64133/Khon Kaen University Faculty of Medicine/
PT  - Journal Article
DEP - 20230609
PL  - Denmark
TA  - Pediatr Transplant
JT  - Pediatric transplantation
JID - 9802574
SB  - IM
MH  - Adolescent
MH  - Young Adult
MH  - Humans
MH  - Child
MH  - Male
MH  - *Kidney Transplantation/adverse effects
MH  - Thailand
MH  - Tissue Donors
MH  - Kidney
MH  - Graft Survival
MH  - Graft Rejection/prevention & control
MH  - *Kidney Failure, Chronic/complications
MH  - Risk Factors
MH  - Delayed Graft Function/etiology
OTO - NOTNLM
OT  - children
OT  - chronic kidney disease
OT  - graft survival
OT  - renal transplantation
OT  - risk factor
EDAT- 2023/06/09 19:42
MHDA- 2024/02/07 06:42
CRDT- 2023/06/09 13:03
PHST- 2022/08/27 00:00 [revised]
PHST- 2022/04/25 00:00 [received]
PHST- 2022/09/30 00:00 [accepted]
PHST- 2024/02/07 06:42 [medline]
PHST- 2023/06/09 19:42 [pubmed]
PHST- 2023/06/09 13:03 [entrez]
AID - 10.1111/petr.14411 [doi]
PST - ppublish
SO  - Pediatr Transplant. 2024 Feb;28(1):e14411. doi: 10.1111/petr.14411. Epub 2023 Jun 
      9.