PMID- 37295234
OWN - NLM
STAT- MEDLINE
DCOM- 20230830
LR  - 20230831
IS  - 1973-8102 (Electronic)
IS  - 0010-9452 (Linking)
VI  - 166
DP  - 2023 Sep
TI  - Comparing two picture naming tasks in primary progressive aphasia: Insights from 
      behavioural and neural results.
PG  - 1-18
LID - S0010-9452(23)00117-X [pii]
LID - 10.1016/j.cortex.2023.04.014 [doi]
AB  - Picture naming tests are widely used to evaluate language impairments in 
      neurodegenerative diseases, especially in Primary Progressive Aphasia (PPA). The 
      available tests differ for many factors affecting the performance, e.g. format of 
      stimuli and their psycholinguistic properties. We aim to identify the most 
      appropriate naming test to be used on PPA according to the clinical and research 
      demands. We investigated the behavioural characteristics, i.e. proportion of 
      correct responses and error type, and their neural correlates in two Italian 
      naming tests, CaGi naming (CaGi) and naming subtest of the Screening for Aphasia 
      in NeuroDegeneration battery (SAND), administered to 52 PPA patients who 
      underwent an FDG-PET scan. We analysed the effectiveness of the tests in 
      distinguishing PPA versus controls and among PPA variants, considering the 
      psycholinguistic variables affecting performance. We explored the brain metabolic 
      correlates of behavioural performance in the tests. SAND, differently from CaGi, 
      has time limits for the response and its items are less frequent and acquired 
      later. SAND and CaGi differed in terms of number of correct responses and error 
      profile, suggesting a higher difficulty to name SAND items compared to CaGi. 
      Semantic errors predominated in CaGi, while anomic and semantic errors were 
      equally frequent in SAND. Both tests distinguished PPA from controls, but SAND 
      outperformed CaGi in discriminating among PPA variants. FDG-PET imaging revealed 
      a shared metabolic involvement of temporal areas associated with lexico-semantic 
      processing, encompassing anterior fusiform, temporal pole, and extending to 
      posterior fusiform in sv-PPA. Concluding, a picture naming test with response 
      time limit and items which are less frequent and acquired later in life, as SAND, 
      may be effective at highlighting subtle distinctions between PPA variants, 
      improving the diagnosis. Conversely, a naming test without time limit for the 
      response, as CaGi, may be useful for a better characterization of the nature of 
      the naming impairment at the behavioural level, eliciting more naming errors than 
      anomia, possibly helping in the development of rehabilitation protocols.
CI  - Copyright (c) 2023 Elsevier Ltd. All rights reserved.
FAU - Polito, Cristina
AU  - Polito C
AD  - IRCCS Fondazione Don Carlo Gnocchi, Florence, Italy.
FAU - Conca, Francesca
AU  - Conca F
AD  - IRCCS Mondino Foundation, Pavia, Italy.
FAU - Santi, Gaia C
AU  - Santi GC
AD  - ICoN Cognitive Neuroscience Center, Institute for Advanced Studies, IUSS, Pavia, 
      Italy.
FAU - Esposito, Valentina
AU  - Esposito V
AD  - IRCCS Mondino Foundation, Pavia, Italy.
FAU - Caminiti, Silvia P
AU  - Caminiti SP
AD  - Vita-Salute San Raffaele University, 20132, Milan, Italy; In Vivo Human Molecular 
      and Structural Neuroimaging Unit, Division of Neuroscience, San Raffaele 
      Scientific Institute, 20132, Milan, Italy; Nuclear Medicine Unit, San Raffaele 
      Hospital, 20132, Milan, Italy.
FAU - Boccalini, Cecilia
AU  - Boccalini C
AD  - Vita-Salute San Raffaele University, 20132, Milan, Italy; In Vivo Human Molecular 
      and Structural Neuroimaging Unit, Division of Neuroscience, San Raffaele 
      Scientific Institute, 20132, Milan, Italy.
FAU - Berti, Valentina
AU  - Berti V
AD  - Nuclear Medicine, Department of Biomedical Experimental and Clinical Sciences 
      "Mario Serio", University of Florence, Italy.
FAU - Morinelli, Carmen
AU  - Morinelli C
AD  - SOD Neurologia 1, Dipartimento Neuromuscolo-Scheletrico e Degli Organi di Senso, 
      Azienda Ospedaliera-Universitaria Careggi, Florence, Italy.
FAU - Mazzeo, Salvatore
AU  - Mazzeo S
AD  - IRCCS Fondazione Don Carlo Gnocchi, Florence, Italy; NEUROFARBA, Department of 
      Neuroscience, Psychology, Drug Research and Child Health, University of Florence, 
      Florence, Italy.
FAU - Marcone, Alessandra
AU  - Marcone A
AD  - Department of Rehabilitation and Functional Recovery, San Raffaele Hospital, 
      Milan, Italy.
FAU - Iannaccone, Sandro
AU  - Iannaccone S
AD  - Department of Rehabilitation and Functional Recovery, San Raffaele Hospital, 
      Milan, Italy.
FAU - Bessi, Valentina
AU  - Bessi V
AD  - IRCCS Fondazione Don Carlo Gnocchi, Florence, Italy; SOD Neurologia 1, 
      Dipartimento Neuromuscolo-Scheletrico e Degli Organi di Senso, Azienda 
      Ospedaliera-Universitaria Careggi, Florence, Italy; NEUROFARBA, Department of 
      Neuroscience, Psychology, Drug Research and Child Health, University of Florence, 
      Florence, Italy.
FAU - Sorbi, Sandro
AU  - Sorbi S
AD  - IRCCS Fondazione Don Carlo Gnocchi, Florence, Italy; SOD Neurologia 1, 
      Dipartimento Neuromuscolo-Scheletrico e Degli Organi di Senso, Azienda 
      Ospedaliera-Universitaria Careggi, Florence, Italy; NEUROFARBA, Department of 
      Neuroscience, Psychology, Drug Research and Child Health, University of Florence, 
      Florence, Italy.
FAU - Perani, Daniela
AU  - Perani D
AD  - Vita-Salute San Raffaele University, 20132, Milan, Italy; In Vivo Human Molecular 
      and Structural Neuroimaging Unit, Division of Neuroscience, San Raffaele 
      Scientific Institute, 20132, Milan, Italy; Nuclear Medicine Unit, San Raffaele 
      Hospital, 20132, Milan, Italy.
FAU - Cappa, Stefano F
AU  - Cappa SF
AD  - IRCCS Mondino Foundation, Pavia, Italy; ICoN Cognitive Neuroscience Center, 
      Institute for Advanced Studies, IUSS, Pavia, Italy. Electronic address: 
      stefano.cappa@iusspavia.it.
FAU - Catricala, Eleonora
AU  - Catricala E
AD  - ICoN Cognitive Neuroscience Center, Institute for Advanced Studies, IUSS, Pavia, 
      Italy.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20230521
PL  - Italy
TA  - Cortex
JT  - Cortex; a journal devoted to the study of the nervous system and behavior
JID - 0100725
SB  - IM
MH  - *Aphasia, Primary Progressive/diagnostic imaging/psychology
MH  - Humans
MH  - Male
MH  - Female
MH  - Aged
MH  - *Neuropsychological Tests
MH  - Positron-Emission Tomography
MH  - Psycholinguistics
MH  - Behavior
MH  - Neuroimaging
MH  - *Brain/diagnostic imaging
OTO - NOTNLM
OT  - Picture naming
OT  - Primary progressive aphasia
OT  - Semantic errors
COIS- Declaration of competing interest None.
EDAT- 2023/06/10 15:13
MHDA- 2023/08/29 12:43
CRDT- 2023/06/09 18:07
PHST- 2022/10/29 00:00 [received]
PHST- 2023/02/24 00:00 [revised]
PHST- 2023/04/26 00:00 [accepted]
PHST- 2023/08/29 12:43 [medline]
PHST- 2023/06/10 15:13 [pubmed]
PHST- 2023/06/09 18:07 [entrez]
AID - S0010-9452(23)00117-X [pii]
AID - 10.1016/j.cortex.2023.04.014 [doi]
PST - ppublish
SO  - Cortex. 2023 Sep;166:1-18. doi: 10.1016/j.cortex.2023.04.014. Epub 2023 May 21.