PMID- 37295458
OWN - NLM
STAT- MEDLINE
DCOM- 20231030
LR  - 20231030
IS  - 1538-9375 (Electronic)
IS  - 1525-8610 (Linking)
VI  - 24
IP  - 11
DP  - 2023 Nov
TI  - Efficacy and Safety of Moderate-Intensity Continuous Training on the Improvement 
      of Cardiopulmonary Function in Patients After Transcatheter Aortic Valve 
      Replacement (ENERGY): A Randomized Controlled Trial.
PG  - 1783-1790.e2
LID - S1525-8610(23)00416-4 [pii]
LID - 10.1016/j.jamda.2023.04.025 [doi]
AB  - OBJECTIVES: To investigate the effect of moderate-intensity continuous training 
      (MICT) on the improvement of cardiopulmonary function for patients undergoing 
      transcatheter aortic valve replacement (TAVR). DESIGN: Randomized controlled 
      study. SETTING AND PARTICIPANTS: Between August 20, 2021, and February 28, 2022, 
      a total of 66 patients after TAVR were screened for inclusion and randomly 
      divided into the MICT and control groups at a ratio of 1:1. MICT was scheduled 3 
      times per week for 3 months in the intervention group. Patients in the control 
      group received one-time advice on physical activity according to the current 
      guideline. METHODS: The primary endpoint was the 3-month change in peak oxygen 
      consumption (peak VO(2)) assessed by cardiopulmonary exercise testing. The 
      secondary endpoints included the 3-month change in 6-minute walk test (6MWT), the 
      12-Item Short Form Health Survey (SF-12), New York Heart Association (NYHA) 
      class, echocardiographic parameters, and laboratory parameters. RESULTS: After 
      3 months, the change in peak VO(2) was higher in the MICT group than that in the 
      control group (1.63 mL/kg/min, 95% CI 0.58-2.67, P = .003). Change in 6MWT 
      (21.55 m, 95% CI 0.38-42.71, P = .046) was higher in the MICT group compared with 
      the control group. A significant change in favor of MICT was also observed for 
      low-density lipoprotein cholesterol (-0.62 mmol/L, 95% CI -1.00 to -0.23, P = 
      .002). However, there were no significant changes in other echocardiographic 
      indices, laboratory parameters, and SF-12 between the 2 groups (all P > .05). 
      CONCLUSIONS AND IMPLICATIONS: MICT had a positive effect on the cardiopulmonary 
      function and physical capacity of patients after TAVR.
CI  - Copyright (c) 2023 AMDA - The Society for Post-Acute and Long-Term Care Medicine. 
      Published by Elsevier Inc. All rights reserved.
FAU - Hu, Qiang
AU  - Hu Q
AD  - Department of Cardiology, General Hospital of Northern Theater Command, Shenyang, 
      China; Department of Cardiology, Air Force Hospital of Western Theater Command, 
      Chengdu, China.
FAU - Li, Yu-Shan
AU  - Li YS
AD  - Department of Cardiology, General Hospital of Northern Theater Command, Shenyang, 
      China.
FAU - Ren, Qiang
AU  - Ren Q
AD  - Department of Cardiology, General Hospital of Northern Theater Command, Shenyang, 
      China.
FAU - Liang, Yan-Chun
AU  - Liang YC
AD  - Department of Cardiology, General Hospital of Northern Theater Command, Shenyang, 
      China.
FAU - Zhang, Jian
AU  - Zhang J
AD  - Department of Cardiology, General Hospital of Northern Theater Command, Shenyang, 
      China.
FAU - Wang, Yan-Xia
AU  - Wang YX
AD  - Department of Cardiology, General Hospital of Northern Theater Command, Shenyang, 
      China.
FAU - Wang, Cai-Lian
AU  - Wang CL
AD  - Department of Cardiology, General Hospital of Northern Theater Command, Shenyang, 
      China.
FAU - Hong, Tai-Lian
AU  - Hong TL
AD  - Department of Cardiology, General Hospital of Northern Theater Command, Shenyang, 
      China.
FAU - Wang, Sheng-Yi
AU  - Wang SY
AD  - Department of Cardiology, General Hospital of Northern Theater Command, Shenyang, 
      China.
FAU - Zhang, Yi
AU  - Zhang Y
AD  - Department of Cardiology, General Hospital of Northern Theater Command, Shenyang, 
      China.
FAU - Zhang, Quan-Yu
AU  - Zhang QY
AD  - Department of Cardiology, General Hospital of Northern Theater Command, Shenyang, 
      China. Electronic address: zqyfmmu@foxmail.com.
FAU - Han, Ya-Ling
AU  - Han YL
AD  - Department of Cardiology, General Hospital of Northern Theater Command, Shenyang, 
      China. Electronic address: hanyaling@163.net.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20230607
PL  - United States
TA  - J Am Med Dir Assoc
JT  - Journal of the American Medical Directors Association
JID - 100893243
SB  - IM
MH  - Humans
MH  - *Transcatheter Aortic Valve Replacement
MH  - Exercise
MH  - Exercise Therapy
MH  - Walking
MH  - *Aortic Valve Stenosis/surgery/complications
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Cardiac rehabilitation
OT  - cardiopulmonary exercise testing
OT  - quality of life
OT  - transcatheter aortic valve replacement
EDAT- 2023/06/10 15:13
MHDA- 2023/10/30 06:46
CRDT- 2023/06/09 19:21
PHST- 2023/02/01 00:00 [received]
PHST- 2023/04/19 00:00 [revised]
PHST- 2023/04/21 00:00 [accepted]
PHST- 2023/10/30 06:46 [medline]
PHST- 2023/06/10 15:13 [pubmed]
PHST- 2023/06/09 19:21 [entrez]
AID - S1525-8610(23)00416-4 [pii]
AID - 10.1016/j.jamda.2023.04.025 [doi]
PST - ppublish
SO  - J Am Med Dir Assoc. 2023 Nov;24(11):1783-1790.e2. doi: 
      10.1016/j.jamda.2023.04.025. Epub 2023 Jun 7.