PMID- 37295809
OWN - NLM
STAT- MEDLINE
DCOM- 20231023
LR  - 20231023
IS  - 1938-9116 (Electronic)
IS  - 1538-5744 (Linking)
VI  - 57
IP  - 8
DP  - 2023 Nov
TI  - Botulinum Toxin Type a for Treating Rest Pain in Chronic Limb-threatening 
      Ischemia: A Case Report.
PG  - 927-931
LID - 10.1177/15385744231183493 [doi]
AB  - Botulinum toxin type A (BoNT/A) is a potent neurotoxin with widely use range, for 
      the good outcomes in the treatment of pain, it was considered as an unique 
      analgesic drugs with the feature of sustained efficacy after a single 
      application, but up to now, treating chronic limb-threatening ischemia (CLTI) 
      with BoNT/A was rarely reported. We present a 91-year-old man with CLTI, the main 
      clinical manifestations were left foot rest pain, intermittent claudication and 
      toe necrosis, the patient refused invasive treatments, and the pain failure to 
      respond to conventional analgesic drugs, the subcutaneous injections of BoNT/A 
      was performed to the patient. The pain score on the visual analog scale (VAS), 
      decreased from 5-6 (before treatment) to 1 within days after infiltration, and 
      keep in 1-2 of VAS during follow-up. Our case report demonstrated that BoNT/A may 
      be an unique minimally invasive solution for treating rest pain in CLTI.
FAU - Xu, Jiaoxiong
AU  - Xu J
AUID- ORCID: 0000-0003-1175-6527
AD  - Department of Dermatology and Burn, Huangpu People's Hospital of Zhongshan, 
      Zhongshan, China. RINGGOLD: 595836
FAU - Lin, Haofeng
AU  - Lin H
AD  - Department of Surgery, Huangpu People's Hospital of Zhongshan, Zhongshan, China. 
      RINGGOLD: 595836
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20230609
PL  - United States
TA  - Vasc Endovascular Surg
JT  - Vascular and endovascular surgery
JID - 101136421
RN  - EC 3.4.24.69 (Botulinum Toxins, Type A)
RN  - 0 (Neuromuscular Agents)
RN  - 0 (Analgesics)
SB  - IM
MH  - Male
MH  - Humans
MH  - Aged, 80 and over
MH  - *Botulinum Toxins, Type A
MH  - *Neuromuscular Agents/therapeutic use
MH  - Chronic Limb-Threatening Ischemia
MH  - Treatment Outcome
MH  - Pain
MH  - Analgesics/therapeutic use
OTO - NOTNLM
OT  - Botulinum toxin type A
OT  - chronic limb-threatening ischemia
OT  - rest pain
OT  - subcutaneous injections
EDAT- 2023/06/10 15:13
MHDA- 2023/10/23 00:42
CRDT- 2023/06/09 20:42
PHST- 2023/10/23 00:42 [medline]
PHST- 2023/06/10 15:13 [pubmed]
PHST- 2023/06/09 20:42 [entrez]
AID - 10.1177/15385744231183493 [doi]
PST - ppublish
SO  - Vasc Endovascular Surg. 2023 Nov;57(8):927-931. doi: 10.1177/15385744231183493. 
      Epub 2023 Jun 9.