PMID- 37297506
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230612
IS  - 2304-8158 (Print)
IS  - 2304-8158 (Electronic)
IS  - 2304-8158 (Linking)
VI  - 12
IP  - 11
DP  - 2023 Jun 4
TI  - Determination of Biogenic Amines in Wine from Chinese Markets Using Ion 
      Chromatography-Tandem Mass Spectrometry.
LID - 10.3390/foods12112262 [doi]
LID - 2262
AB  - A method for the determination of nine biogenic amines (BAs) in wine was 
      established using ion chromatography-tandem mass spectrometry (IC-MS/MS) without 
      derivatization. BAs were separated by a cation exchange column (IonPac CG17, 50 
      mm x 4 mm, 7 microm) with a gradient aqueous formic acid elution. Good linearity was 
      obtained for nine BAs with coefficients of determination (R(2)) > 0.9972 within 
      the range of 0.01-50 mg/L. The limits of detection and quantification were within 
      the ranges of 0.6-40 microg/L and 2.0-135 microg/L, respectively, with the exception of 
      spermine (SPM). The recoveries were demonstrated within the range of 82.6-103.0%, 
      with relative standard deviations (RSDs) of less than 4.2%. This simple method 
      featuring excellent sensitivity and selectivity was suitable for the 
      quantification of BAs in wines. The occurrence of BAs in 236 wine samples that 
      are commercially available in China was determined. The BA levels in wines of 
      different geographical origins varied significantly. The acute dietary exposure 
      assessment of BAs was carried out by calculating the estimated short-term intake 
      (ESTI) and comparing the acute reference dose (ARfD) specified by the European 
      Food Safety Authority (EFSA). Results showed that the exposure to histamine (HIS) 
      and tyramine (TYR) via the consumption of wines was much lower than the 
      recommended ARfD level for healthy individuals. However, exposure could lead to 
      symptoms in susceptible individuals. These results provided basic data regarding 
      the occurrence and risk of BAs in wines for wine production, health guidance and 
      consumer safety.
FAU - Zhu, Zuoyi
AU  - Zhu Z
AD  - Institute of Agro-Product Safety and Nutrition, Zhejiang Academy of Agricultural 
      Science, Hangzhou 310021, China.
FAU - Song, Xinyue
AU  - Song X
AD  - College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 
      310014, China.
FAU - Jiang, Yunzhu
AU  - Jiang Y
AD  - Institute of Agro-Product Safety and Nutrition, Zhejiang Academy of Agricultural 
      Science, Hangzhou 310021, China.
FAU - Yao, Jiarong
AU  - Yao J
AD  - Institute of Agro-Product Safety and Nutrition, Zhejiang Academy of Agricultural 
      Science, Hangzhou 310021, China.
FAU - Li, Zhen
AU  - Li Z
AD  - Institute of Agro-Product Safety and Nutrition, Zhejiang Academy of Agricultural 
      Science, Hangzhou 310021, China.
FAU - Dai, Fen
AU  - Dai F
AD  - Institute of Agro-Product Safety and Nutrition, Zhejiang Academy of Agricultural 
      Science, Hangzhou 310021, China.
FAU - Wang, Qiang
AU  - Wang Q
AD  - Institute of Agro-Product Safety and Nutrition, Zhejiang Academy of Agricultural 
      Science, Hangzhou 310021, China.
LA  - eng
GR  - CARS-29/China Agriculture Research System/
PT  - Journal Article
DEP - 20230604
PL  - Switzerland
TA  - Foods
JT  - Foods (Basel, Switzerland)
JID - 101670569
PMC - PMC10252581
OTO - NOTNLM
OT  - biogenic amines
OT  - ion chromatography-tandem mass spectrometry
OT  - risk assessment
OT  - wine
COIS- The authors declare no conflict of interest.
EDAT- 2023/06/10 15:13
MHDA- 2023/06/10 15:14
PMCR- 2023/06/04
CRDT- 2023/06/10 01:07
PHST- 2023/04/25 00:00 [received]
PHST- 2023/05/24 00:00 [revised]
PHST- 2023/05/30 00:00 [accepted]
PHST- 2023/06/10 15:14 [medline]
PHST- 2023/06/10 15:13 [pubmed]
PHST- 2023/06/10 01:07 [entrez]
PHST- 2023/06/04 00:00 [pmc-release]
AID - foods12112262 [pii]
AID - foods-12-02262 [pii]
AID - 10.3390/foods12112262 [doi]
PST - epublish
SO  - Foods. 2023 Jun 4;12(11):2262. doi: 10.3390/foods12112262.