PMID- 37298291
OWN - NLM
STAT- MEDLINE
DCOM- 20230612
LR  - 20230612
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 24
IP  - 11
DP  - 2023 May 26
TI  - Targeting the Inflammatory Hallmarks of Obesity-Associated Osteoarthritis: 
      Towards Nutraceutical-Oriented Preventive and Complementary Therapeutic 
      Strategies Based on n-3 Polyunsaturated Fatty Acids.
LID - 10.3390/ijms24119340 [doi]
LID - 9340
AB  - Obesity (Ob), which has dramatically increased in the last decade, is one of the 
      main risk factors that contribute to the incidence and progression of 
      osteoarthritis (OA). Targeting the characteristics of obesity-associated 
      osteoarthritis (ObOA) may offer new chances for precision medicine strategies in 
      this patient cohort. First, this review outlines how the medical perspective of 
      ObOA has shifted from a focus on biomechanics to the significant contribution of 
      inflammation, mainly mediated by changes in the adipose tissue metabolism through 
      the release of adipokines and the modification of fatty acid (FA) compositions in 
      joint tissues. Preclinical and clinical studies on n-3 polyunsaturated FAs 
      (PUFAs) are critically reviewed to outline the strengths and weaknesses of n-3 
      PUFAs' role in alleviating inflammatory, catabolic and painful processes. 
      Emphasis is placed on potential preventive and therapeutic nutritional strategies 
      based on n-3 PUFAs, with a focus on ObOA patients who could specifically benefit 
      from reformulating the dietary composition of FAs towards a protective phenotype. 
      Finally, tissue engineering approaches that involve the delivery of n-3 PUFAs 
      directly into the joint are explored to address the perspectives and current 
      limitations, such as safety and stability issues, for implementing preventive and 
      therapeutic strategies based on dietary compounds in ObOA patients.
FAU - Gambari, Laura
AU  - Gambari L
AUID- ORCID: 0000-0001-8126-5040
AD  - Laboratorio Ramses, IRCCS Istituto Ortopedico Rizzoli, via di Barbiano 1/10, 
      40136 Bologna, Italy.
FAU - Cellamare, Antonella
AU  - Cellamare A
AD  - Laboratorio Ramses, IRCCS Istituto Ortopedico Rizzoli, via di Barbiano 1/10, 
      40136 Bologna, Italy.
FAU - Grassi, Francesco
AU  - Grassi F
AUID- ORCID: 0000-0002-5127-9561
AD  - Laboratorio Ramses, IRCCS Istituto Ortopedico Rizzoli, via di Barbiano 1/10, 
      40136 Bologna, Italy.
FAU - Grigolo, Brunella
AU  - Grigolo B
AUID- ORCID: 0000-0002-3990-6745
AD  - Laboratorio Ramses, IRCCS Istituto Ortopedico Rizzoli, via di Barbiano 1/10, 
      40136 Bologna, Italy.
FAU - Panciera, Alessandro
AU  - Panciera A
AD  - 1st Orthopedic and Traumatology Clinic, IRCCS Istituto Ortopedico Rizzoli, via 
      G.C. Pupilli 1, 40136 Bologna, Italy.
FAU - Ruffilli, Alberto
AU  - Ruffilli A
AD  - 1st Orthopedic and Traumatology Clinic, IRCCS Istituto Ortopedico Rizzoli, via 
      G.C. Pupilli 1, 40136 Bologna, Italy.
FAU - Faldini, Cesare
AU  - Faldini C
AD  - 1st Orthopedic and Traumatology Clinic, IRCCS Istituto Ortopedico Rizzoli, via 
      G.C. Pupilli 1, 40136 Bologna, Italy.
FAU - Desando, Giovanna
AU  - Desando G
AUID- ORCID: 0000-0003-3338-5747
AD  - Laboratorio Ramses, IRCCS Istituto Ortopedico Rizzoli, via di Barbiano 1/10, 
      40136 Bologna, Italy.
LA  - eng
GR  - GR-2019-12370030/Italian Ministry of Health/
PT  - Journal Article
PT  - Review
DEP - 20230526
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - 0 (Fatty Acids, Omega-3)
RN  - 0 (Fatty Acids)
SB  - IM
MH  - Humans
MH  - *Fatty Acids, Omega-3/therapeutic use/metabolism
MH  - *Osteoarthritis/etiology/prevention & control
MH  - Obesity/complications/metabolism
MH  - Adipose Tissue/metabolism
MH  - Fatty Acids/metabolism
MH  - Dietary Supplements
PMC - PMC10253881
OTO - NOTNLM
OT  - dietary supplementation
OT  - dysbiosis
OT  - inflammation
OT  - intra-articular deliveries
OT  - n-3 polyunsaturated fatty acids
OT  - nutraceuticals
OT  - obesity
OT  - osteoarthritis
OT  - pain
OT  - phytochemicals
OT  - translational interventions
COIS- The authors declare no conflict of interest.
EDAT- 2023/06/10 15:13
MHDA- 2023/06/12 06:43
PMCR- 2023/05/26
CRDT- 2023/06/10 01:11
PHST- 2023/03/15 00:00 [received]
PHST- 2023/05/15 00:00 [revised]
PHST- 2023/05/23 00:00 [accepted]
PHST- 2023/06/12 06:43 [medline]
PHST- 2023/06/10 15:13 [pubmed]
PHST- 2023/06/10 01:11 [entrez]
PHST- 2023/05/26 00:00 [pmc-release]
AID - ijms24119340 [pii]
AID - ijms-24-09340 [pii]
AID - 10.3390/ijms24119340 [doi]
PST - epublish
SO  - Int J Mol Sci. 2023 May 26;24(11):9340. doi: 10.3390/ijms24119340.