PMID- 37298692
OWN - NLM
STAT- MEDLINE
DCOM- 20230612
LR  - 20230612
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 24
IP  - 11
DP  - 2023 Jun 4
TI  - Common Genetic Variants of Response to Hepatitis B Vaccines Correlate with Risks 
      of Chronic Infection of Hepatitis B Virus: A Community-Based Case-Control Study.
LID - 10.3390/ijms24119741 [doi]
LID - 9741
AB  - Hepatitis B (HB) vaccination effectively reduces the risks of chronic infection 
      with the hepatitis B virus (HBV). It is unknown whether there is a common genetic 
      determinant for response to the HB vaccine and susceptibility to chronic HBV 
      infection. This case-control study, which included 193 chronic HBV carriers and 
      495 non-carriers, aimed to explore the effects of the most significant single 
      nucleotide polymorphisms (SNPs) in response to the HB vaccine on the risks of 
      chronic HBV infection. Out of 13 tested SNPs, the genotype distributions of four 
      SNPs at the human leukocyte antigen (HLA) class II region, including rs34039593, 
      rs614348, rs7770370, and rs9277535, were significantly different between HBV 
      carriers and non-carriers. The age-sex-adjusted odds ratios (OR) of chronic HBV 
      infection for rs34039593 TG, rs614348 TC, rs7770370 AA, and rs9277535 AA 
      genotypes were 0.51 (95% confidence interval [CI], 0.33-0.79; p = 0.0028), 0.49 
      (95% CI, 0.32-0.75; p = 6.5 x 10(-4)), 0.33 (95% CI, 0.18-0.63; p = 7.4 x 
      10(-4)), and 0.31 (95% CI, 0.14-0.70; p = 0.0043), respectively. Multivariable 
      analyses showed that rs614348 TC and rs7770370 AA genotypes were significantly 
      independent protectors against chronic HBV infection. The multivariable-adjusted 
      ORs for subjects with none, either one, or both of the protective genotypes were 
      1.00 (referent), 0.47 (95% CI: 0.32-0.71; p = 3.0 x 10(-4)), and 0.16 (95% CI: 
      0.05-0.54; p = 0.0032), respectively. Among eight HBeAg-positive carriers, only 
      one of them carried a protective genotype. This study shows that response to the 
      HB vaccine and susceptibility to chronic HBV infection share common genetic 
      determinants and indicates that HLA class II members are the main responsible 
      host genetic factors.
FAU - Wu, Tzu-Wei
AU  - Wu TW
AD  - Department of Medicine, MacKay Medical College, New Taipei City 252, Taiwan.
FAU - Chou, Chao-Liang
AU  - Chou CL
AD  - Department of Medicine, MacKay Medical College, New Taipei City 252, Taiwan.
AD  - Department of Neurology, MacKay Memorial Hospital, New Taipei City 251, Taiwan.
FAU - Chen, Chuen-Fei
AU  - Chen CF
AD  - Department of Medicine, MacKay Medical College, New Taipei City 252, Taiwan.
FAU - Wang, Li-Yu
AU  - Wang LY
AUID- ORCID: 0000-0001-9101-5694
AD  - Department of Medicine, MacKay Medical College, New Taipei City 252, Taiwan.
LA  - eng
GR  - MOST 108-2314-B-715-005-MY3; MOST 111-2314-B-715-007/Council of Science and 
      Technology of Taiwan/
GR  - MMC-RD-110-1B-P010 & MMC-RD-111-1B-P007/MacKay Medical College/
PT  - Journal Article
DEP - 20230604
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - 0 (Hepatitis B Vaccines)
SB  - IM
MH  - Humans
MH  - Hepatitis B virus/genetics
MH  - Hepatitis B Vaccines
MH  - Case-Control Studies
MH  - *Hepatitis B, Chronic/genetics/prevention & control
MH  - Persistent Infection
MH  - Genotype
MH  - Polymorphism, Single Nucleotide
MH  - *Hepatitis B/genetics
MH  - Genetic Predisposition to Disease
PMC - PMC10253545
OTO - NOTNLM
OT  - case-control study
OT  - community-based study
OT  - hepatitis B
OT  - hepatitis B vaccination
OT  - hepatitis B virus
OT  - human leukocyte antigen
OT  - single nucleotide polymorphism
COIS- The authors declare no conflict of interest. The funders had no role in the 
      design of the study.
EDAT- 2023/06/10 15:13
MHDA- 2023/06/12 06:42
PMCR- 2023/06/04
CRDT- 2023/06/10 01:14
PHST- 2023/05/08 00:00 [received]
PHST- 2023/05/26 00:00 [revised]
PHST- 2023/06/02 00:00 [accepted]
PHST- 2023/06/12 06:42 [medline]
PHST- 2023/06/10 15:13 [pubmed]
PHST- 2023/06/10 01:14 [entrez]
PHST- 2023/06/04 00:00 [pmc-release]
AID - ijms24119741 [pii]
AID - ijms-24-09741 [pii]
AID - 10.3390/ijms24119741 [doi]
PST - epublish
SO  - Int J Mol Sci. 2023 Jun 4;24(11):9741. doi: 10.3390/ijms24119741.