PMID- 37299403
OWN - NLM
STAT- MEDLINE
DCOM- 20230612
LR  - 20230715
IS  - 2072-6643 (Electronic)
IS  - 2072-6643 (Linking)
VI  - 15
IP  - 11
DP  - 2023 May 24
TI  - Inflammatory Mediators and Type 2 Diabetes Risk Factors before and in Response to 
      Lifestyle Intervention among Latino Adolescents with Obesity.
LID - 10.3390/nu15112442 [doi]
LID - 2442
AB  - Obesity is associated with chronic inflammation that may contribute to T2D among 
      youth. We examined the association between inflammatory biomarkers and insulin 
      sensitivity and beta-cell function and response to lifestyle intervention among 
      Latino youth with obesity. Latino youth (n = 64) were randomized to six months of 
      lifestyle intervention (INT, n = 40) or usual care (UC, n = 24). INT included 
      nutrition education and physical activity. UC involved meeting with a pediatric 
      endocrinologist and registered dietitian to discuss healthy lifestyles. At 
      baseline, multiple linear regression assessed fasting serum interleukin-6 (IL-6), 
      tumor necrosis factor-alpha (TNF-alpha), monocyte chemoattractant protein-1 (MCP-1), 
      high-molecular weight adiponectin (HMW Adpn), IL-10, IL-1 receptor antagonist 
      (IL-1ra) as predictors of insulin sensitivity (whole-body insulin sensitivity 
      index, WBISI) and beta-cell function (oral disposition index, oDI). Changes in 
      outcomes between groups were assessed using covariance pattern models. At 
      baseline, MCP-1 (beta +/- SE, -0.12 +/- 0.05, p = 0.027) and IL-1ra (-0.03 +/- 0.01, p = 
      0.005) were negatively associated with WBISI. Treatment effects were not observed 
      for inflammatory markers. WBISI was significantly increased among both INT (from 
      1.8 +/- 0.2 to 2.6 +/- 0.4, p = 0.005) and UC (from 1.6 +/- 0.2 to 2.8 +/- 0.5, p = 
      0.002) with no significant differences between the groups. Obesity-related 
      inflammatory mediators were associated with T2D risk factors but were unaffected 
      by lifestyle intervention among Latino youth.
FAU - Pena, Armando
AU  - Pena A
AUID- ORCID: 0000-0002-8219-9433
AD  - Department of Health and Wellness Design, School of Public Health-Bloomington, 
      Indiana University, Bloomington, IN 47405, USA.
AD  - College of Health Solutions, Arizona State University, Phoenix, AZ 85004, USA.
AD  - Center for Health Promotion and Disease Prevention, Arizona State University, 
      Phoenix, AZ 85004, USA.
FAU - Olson, Micah L
AU  - Olson ML
AD  - Center for Health Promotion and Disease Prevention, Arizona State University, 
      Phoenix, AZ 85004, USA.
AD  - Division of Pediatric Endocrinology and Diabetes, Phoenix Children's Hospital, 
      Phoenix, AZ 85016, USA.
FAU - Ayers, Stephanie L
AU  - Ayers SL
AD  - Southwestern Interdisciplinary Research Center, Arizona State University, 
      Phoenix, AZ 85004, USA.
FAU - Sears, Dorothy D
AU  - Sears DD
AUID- ORCID: 0000-0002-9260-3540
AD  - College of Health Solutions, Arizona State University, Phoenix, AZ 85004, USA.
FAU - Vega-Lopez, Sonia
AU  - Vega-Lopez S
AUID- ORCID: 0000-0001-8089-0725
AD  - College of Health Solutions, Arizona State University, Phoenix, AZ 85004, USA.
AD  - Southwestern Interdisciplinary Research Center, Arizona State University, 
      Phoenix, AZ 85004, USA.
FAU - Colburn, Abigail T
AU  - Colburn AT
AUID- ORCID: 0000-0002-9086-1730
AD  - Obstetrics, Gynecology and Reproductive Sciences, Yale School of Medicine, New 
      Haven, CT 06510, USA.
AD  - John B. Pierce Laboratory, Yale School of Medicine, New Haven, CT 06519, USA.
FAU - Shaibi, Gabriel Q
AU  - Shaibi GQ
AD  - Center for Health Promotion and Disease Prevention, Arizona State University, 
      Phoenix, AZ 85004, USA.
AD  - Division of Pediatric Endocrinology and Diabetes, Phoenix Children's Hospital, 
      Phoenix, AZ 85016, USA.
AD  - Southwestern Interdisciplinary Research Center, Arizona State University, 
      Phoenix, AZ 85004, USA.
LA  - eng
GR  - R01DK107579-03S1/DK/NIDDK NIH HHS/United States
GR  - F31 DK125037/DK/NIDDK NIH HHS/United States
GR  - F31DK125037/DK/NIDDK NIH HHS/United States
GR  - R01DK107579/DK/NIDDK NIH HHS/United States
GR  - R01 DK107579/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20230524
PL  - Switzerland
TA  - Nutrients
JT  - Nutrients
JID - 101521595
RN  - 0 (Interleukin 1 Receptor Antagonist Protein)
RN  - 0 (Inflammation Mediators)
SB  - IM
MH  - Adolescent
MH  - Child
MH  - Humans
MH  - *Insulin Resistance
MH  - Interleukin 1 Receptor Antagonist Protein
MH  - Inflammation Mediators
MH  - *Diabetes Mellitus, Type 2/complications
MH  - Obesity/complications
MH  - Life Style
MH  - Risk Factors
MH  - Hispanic or Latino
PMC - PMC10255740
OTO - NOTNLM
OT  - adipokine
OT  - diabetes prevention
OT  - exercise
OT  - inflammation
OT  - nutrition
OT  - pediatric obesity
COIS- The authors declare no conflict of interest.
EDAT- 2023/06/10 15:14
MHDA- 2023/06/12 06:43
PMCR- 2023/05/24
CRDT- 2023/06/10 01:18
PHST- 2023/04/11 00:00 [received]
PHST- 2023/05/15 00:00 [revised]
PHST- 2023/05/23 00:00 [accepted]
PHST- 2023/06/12 06:43 [medline]
PHST- 2023/06/10 15:14 [pubmed]
PHST- 2023/06/10 01:18 [entrez]
PHST- 2023/05/24 00:00 [pmc-release]
AID - nu15112442 [pii]
AID - nutrients-15-02442 [pii]
AID - 10.3390/nu15112442 [doi]
PST - epublish
SO  - Nutrients. 2023 May 24;15(11):2442. doi: 10.3390/nu15112442.