PMID- 37299522
OWN - NLM
STAT- MEDLINE
DCOM- 20230612
LR  - 20230612
IS  - 2072-6643 (Electronic)
IS  - 2072-6643 (Linking)
VI  - 15
IP  - 11
DP  - 2023 May 30
TI  - Annona muricate Extract Supplementation Contributes to Improve Aberrant 
      Multi-Organ Energy Metabolism via Muscle-Brain Connectivity in Diabetic Mice.
LID - 10.3390/nu15112559 [doi]
LID - 2559
AB  - Type 2 diabetes mellitus (T2DM) is related with the incidence of sarcopenia and 
      cognitive impairment that reduces quality of life in the elderly. Recent evidence 
      has demonstrated that sarcopenia is associated with cognitive dysfunction, and 
      muscle-derived endocrine factors might contribute to cognitive function by the 
      skeletal muscle-brain endocrine loop. This study investigated the beneficial 
      effects of Annona muricata (AM, graviola) on multi-organ energy metabolism with 
      muscle-brain connectivity via brain function-related myokines in mice. Body 
      composition, fasting blood glucose level, insulin, HbA1c%, histopathological 
      changes, and the protein levels of insulin-signaling, energy metabolism, 
      neuroprotection, inflammation, and protein-degradation pathways were measured. AM 
      extract (AME) treatment selectively enhanced insulin signaling in the skeletal 
      muscle and hippocampus of T2DM mice. Furthermore, AME treatment effectively 
      increased muscle-derived fibroblast growth factor 21 (FGF21), cathepsin-B (CTSB), 
      irisin, brain-derived neurotrophic factor (BDNF), and liver-derived FGF21 that 
      contribute to whole-body energy homeostasis. In particular, AME increased the 
      levels of circulating myokines (FGF21, BDNF, irisin, and CTSB), and these were 
      accordance with the hippocampal neurotrophic factors (BDNF and CTSB) in T2DM 
      mice. In conclusion, we suggest that AME would be a potential nutraceutical for 
      improving the energy metabolism associated with muscle-brain connectivity via 
      brain function-related myokines in T2DM.
FAU - Lee, Heaji
AU  - Lee H
AD  - Department of Food and Nutrition, Kyung Hee University, 26 Kyunghee-Daero, 
      Dongdaemun-Gu, Seoul 02447, Republic of Korea.
FAU - Kim, Sun Yeou
AU  - Kim SY
AUID- ORCID: 0000-0001-8044-5613
AD  - Gachon Institute of Pharmaceutical Science, Gachon University, 191 Hambakmoero, 
      Yeonsu-gu, Incheon 21936, Republic of Korea.
FAU - Lim, Yunsook
AU  - Lim Y
AUID- ORCID: 0000-0002-3408-8595
AD  - Department of Food and Nutrition, Kyung Hee University, 26 Kyunghee-Daero, 
      Dongdaemun-Gu, Seoul 02447, Republic of Korea.
LA  - eng
GR  - 2021R1A2C2007708/Ministry of Education/
PT  - Journal Article
DEP - 20230530
PL  - Switzerland
TA  - Nutrients
JT  - Nutrients
JID - 101521595
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Fibronectins)
RN  - 0 (Insulin)
SB  - IM
MH  - Mice
MH  - Animals
MH  - *Diabetes Mellitus, Type 2/complications
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - *Annona/metabolism
MH  - *Diabetes Mellitus, Experimental/complications
MH  - *Sarcopenia/complications
MH  - Fibronectins/metabolism
MH  - Quality of Life
MH  - Muscle, Skeletal/metabolism
MH  - Brain/metabolism
MH  - Insulin/metabolism
MH  - Dietary Supplements
MH  - Energy Metabolism
PMC - PMC10255086
OTO - NOTNLM
OT  - brain
OT  - cognitive dysfunction
OT  - energy metabolism
OT  - hepatokines
OT  - myokines
OT  - sarcopenia
OT  - skeletal muscle
OT  - type 2 diabetes mellitus
COIS- The authors declare no conflict of interest.
EDAT- 2023/06/10 15:14
MHDA- 2023/06/12 06:43
PMCR- 2023/05/30
CRDT- 2023/06/10 01:19
PHST- 2023/05/09 00:00 [received]
PHST- 2023/05/28 00:00 [revised]
PHST- 2023/05/29 00:00 [accepted]
PHST- 2023/06/12 06:43 [medline]
PHST- 2023/06/10 15:14 [pubmed]
PHST- 2023/06/10 01:19 [entrez]
PHST- 2023/05/30 00:00 [pmc-release]
AID - nu15112559 [pii]
AID - nutrients-15-02559 [pii]
AID - 10.3390/nu15112559 [doi]
PST - epublish
SO  - Nutrients. 2023 May 30;15(11):2559. doi: 10.3390/nu15112559.