PMID- 37299745
OWN - NLM
STAT- MEDLINE
DCOM- 20230612
LR  - 20230612
IS  - 1424-8220 (Electronic)
IS  - 1424-8220 (Linking)
VI  - 23
IP  - 11
DP  - 2023 May 24
TI  - Solid-Phase Optical Sensing Techniques for Sensitive Virus Detection.
LID - 10.3390/s23115018 [doi]
LID - 5018
AB  - Viral infections can pose a major threat to public health by causing serious 
      illness, leading to pandemics, and burdening healthcare systems. The global 
      spread of such infections causes disruptions to every aspect of life including 
      business, education, and social life. Fast and accurate diagnosis of viral 
      infections has significant implications for saving lives, preventing the spread 
      of the diseases, and minimizing social and economic damages. Polymerase chain 
      reaction (PCR)-based techniques are commonly used to detect viruses in the 
      clinic. However, PCR has several drawbacks, as highlighted during the recent 
      COVID-19 pandemic, such as long processing times and the requirement for 
      sophisticated laboratory instruments. Therefore, there is an urgent need for fast 
      and accurate techniques for virus detection. For this purpose, a variety of 
      biosensor systems are being developed to provide rapid, sensitive, and 
      high-throughput viral diagnostic platforms, enabling quick diagnosis and 
      efficient control of the virus's spread. Optical devices, in particular, are of 
      great interest due to their advantages such as high sensitivity and direct 
      readout. The current review discusses solid-phase optical sensing techniques for 
      virus detection, including fluorescence-based sensors, surface plasmon resonance 
      (SPR), surface-enhanced Raman scattering (SERS), optical resonators, and 
      interferometry-based platforms. Then, we focus on an interferometric biosensor 
      developed by our group, the single-particle interferometric reflectance imaging 
      sensor (SP-IRIS), which has the capability to visualize single nanoparticles, to 
      demonstrate its application for digital virus detection.
FAU - Seymour, Elif
AU  - Seymour E
AD  - Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M4P 
      1R2, Canada.
AD  - Department of Biomedical Engineering, Boston University, Boston, MA 02215, USA.
FAU - Ekiz Kanik, Fulya
AU  - Ekiz Kanik F
AD  - Department of Electrical Engineering, Boston University, Boston, MA 02215, USA.
FAU - Diken Gur, Sinem
AU  - Diken Gur S
AUID- ORCID: 0000-0001-6105-4609
AD  - Department of Biology, Hacettepe University, Ankara 06800, Turkiye.
FAU - Bakhshpour-Yucel, Monireh
AU  - Bakhshpour-Yucel M
AUID- ORCID: 0000-0002-5737-720X
AD  - Department of Electrical Engineering, Boston University, Boston, MA 02215, USA.
AD  - Department of Chemistry, Bursa Uludag University, Bursa 16059, Turkiye.
FAU - Araz, Ali
AU  - Araz A
AD  - Department of Chemistry, Dokuz Eylul University, Izmir 35390, Turkiye.
FAU - Lortlar Unlu, Nese
AU  - Lortlar Unlu N
AD  - Department of Biomedical Engineering, Boston University, Boston, MA 02215, USA.
FAU - Unlu, M Selim
AU  - Unlu MS
AUID- ORCID: 0000-0002-8594-892X
AD  - Department of Biomedical Engineering, Boston University, Boston, MA 02215, USA.
AD  - Department of Electrical Engineering, Boston University, Boston, MA 02215, USA.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20230524
PL  - Switzerland
TA  - Sensors (Basel)
JT  - Sensors (Basel, Switzerland)
JID - 101204366
SB  - IM
MH  - Humans
MH  - *COVID-19/diagnosis
MH  - Pandemics
MH  - *Biosensing Techniques/methods
MH  - Surface Plasmon Resonance/methods
MH  - *Viruses
PMC - PMC10255700
OTO - NOTNLM
OT  - fluorescence-based sensors
OT  - interferometric biosensors
OT  - optical resonators
OT  - single-virus detection
OT  - solid-phase optical biosensors
OT  - surface plasmon resonance
OT  - virus diagnostics
COIS- The authors declare no conflict of interest.
EDAT- 2023/06/10 15:14
MHDA- 2023/06/12 06:43
PMCR- 2023/05/24
CRDT- 2023/06/10 01:20
PHST- 2023/04/18 00:00 [received]
PHST- 2023/05/15 00:00 [revised]
PHST- 2023/05/16 00:00 [accepted]
PHST- 2023/06/12 06:43 [medline]
PHST- 2023/06/10 15:14 [pubmed]
PHST- 2023/06/10 01:20 [entrez]
PHST- 2023/05/24 00:00 [pmc-release]
AID - s23115018 [pii]
AID - sensors-23-05018 [pii]
AID - 10.3390/s23115018 [doi]
PST - epublish
SO  - Sensors (Basel). 2023 May 24;23(11):5018. doi: 10.3390/s23115018.