PMID- 37301401
OWN - NLM
STAT- MEDLINE
DCOM- 20230710
LR  - 20230718
IS  - 1879-1026 (Electronic)
IS  - 0048-9697 (Linking)
VI  - 892
DP  - 2023 Sep 20
TI  - Organophosphate esters, airway inflammation, and lung function among U.S. 
      participants: A nationally representative cross-sectional study from NHANES, 
      2011-2012.
PG  - 164755
LID - S0048-9697(23)03378-8 [pii]
LID - 10.1016/j.scitotenv.2023.164755 [doi]
AB  - BACKGROUND: Human beings are widespread exposed to organophosphate esters (OPEs), 
      but little is known about their effects on respiratory health. OBJECTIVES: To 
      investigate the associations of exposure to OPEs with lung function and airway 
      inflammation among U.S. participants from NHANES, 2011-2012. METHODS: A total of 
      1636 participants aged 6-79 years were included. Concentrations of OPE 
      metabolites were measured in urine and lung function was assessed with 
      spirometry. Fractional exhaled nitric oxide (FeNO) and blood eosinophils (B-Eos), 
      two important inflammatory biomarkers, were also measured. Linear regression was 
      performed to examine the relationships of OPEs with FeNO, B-Eos and lung 
      function. Bayesian kernel machine regression (BKMR) was used to evaluate the 
      joint associations between OPEs mixtures and lung function. RESULTS: Three of 
      seven OPE metabolites had detection frequencies > 80 %, including diphenyl 
      phosphate (DPHP), bis (1,3-dichloro-2-propyl) phosphate (BDCPP), 
      bis-2-chloroethyl phosphate (BCEP). A 10-fold increase in DPHP concentrations 
      were associated with 1.02 mL decreases in FEV(1) (beta = -0.01, 95 % CIs = -0.02, 
      -0.003) and FVC (beta = -0.01, 95 % CIs = -0.02, -0.003), respectively, and the 
      similar, modest decreases were seen for BDCPP. For each 10-fold increase in BCEP 
      concentration, FVC was also reduced by 1.02 mL (beta = -0.01, 95 % CIs = -0.02, 
      -0.002). Moreover, the negative associations were only found in non-smokers aged 
      >35 years. The aforementioned associations were confirmed by BKMR, but we cannot 
      definitively identify a constituent driving this association. B-Eos was 
      negatively associated with FEV(1) and FEV(1)/FVC, but not with OPEs. No 
      associations were found of FeNO with OPEs and lung function. CONCLUSIONS: 
      Exposure to OPEs was associated with modest decrements in lung function, although 
      the observed decrease in FVC and FEV(1) is unlikely to be of real clinical 
      relevance for the majority of subjects in this series. Moreover, those 
      associations presented age and smoking status-dependent pattern. Unexpectedly, 
      the adverse effect was not mediated by FeNO/B-Eos.
CI  - Copyright (c) 2023 Elsevier B.V. All rights reserved.
FAU - Hu, Peipei
AU  - Hu P
AD  - Department of Pediatrics, Xinhua Hospital, Shanghai Jiao Tong University School 
      of Medicine, Shanghai, China; Ministry of Education-Shanghai Key Laboratory of 
      Children's Environmental Health, Xinhua Hospital, Shanghai Jiao Tong University 
      School of Medicine, Shanghai, China.
FAU - Ke, Shujun
AU  - Ke S
AD  - Department of Radiology, Shanghai Children's Hospital, Shanghai Jiao Tong 
      University School of Medicine, Shanghai, China. Electronic address: 
      keshujun@shchildren.com.cn.
FAU - Vinturache, Angela
AU  - Vinturache A
AD  - Department of Obstetrics & Gynecology, University of Alberta, Edmonton, Alberta, 
      Canada; Department of Neuroscience, University of Lethbridge, Lethbridge, 
      Alberta, Canada.
FAU - Chen, Yan
AU  - Chen Y
AD  - Department of Pediatrics, Xinhua Hospital, Shanghai Jiao Tong University School 
      of Medicine, Shanghai, China; Ministry of Education-Shanghai Key Laboratory of 
      Children's Environmental Health, Xinhua Hospital, Shanghai Jiao Tong University 
      School of Medicine, Shanghai, China.
FAU - Ding, Guodong
AU  - Ding G
AD  - Department of Pediatrics, Xinhua Hospital, Shanghai Jiao Tong University School 
      of Medicine, Shanghai, China; Ministry of Education-Shanghai Key Laboratory of 
      Children's Environmental Health, Xinhua Hospital, Shanghai Jiao Tong University 
      School of Medicine, Shanghai, China. Electronic address: dingguodong@sjtu.edu.cn.
FAU - Zhang, Yongjun
AU  - Zhang Y
AD  - Department of Pediatrics, Xinhua Hospital, Shanghai Jiao Tong University School 
      of Medicine, Shanghai, China; Ministry of Education-Shanghai Key Laboratory of 
      Children's Environmental Health, Xinhua Hospital, Shanghai Jiao Tong University 
      School of Medicine, Shanghai, China. Electronic address: 
      zhangyongjun@sjtu.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20230608
PL  - Netherlands
TA  - Sci Total Environ
JT  - The Science of the total environment
JID - 0330500
RN  - 0 (bis(1,3-dichloropropyl)phosphate)
RN  - 0 (Flame Retardants)
RN  - 0 (Organophosphates)
RN  - 0 (Phosphates)
RN  - 2L9GJK6MGN (diphenyl)
RN  - 0 (Esters)
SB  - IM
MH  - Humans
MH  - Cross-Sectional Studies
MH  - Nutrition Surveys
MH  - Bayes Theorem
MH  - *Flame Retardants/metabolism
MH  - Organophosphates/metabolism
MH  - Phosphates
MH  - Esters/urine
MH  - Lung/metabolism
OTO - NOTNLM
OT  - Bayesian kernel machine regression
OT  - Lung function
OT  - NHANES
OT  - Organophosphate esters
OT  - Respiratory inflammation
COIS- Declaration of competing interest The authors have no conflicts of interest to 
      declare.
EDAT- 2023/06/11 01:06
MHDA- 2023/07/10 06:42
CRDT- 2023/06/10 19:28
PHST- 2022/12/27 00:00 [received]
PHST- 2023/06/06 00:00 [revised]
PHST- 2023/06/06 00:00 [accepted]
PHST- 2023/07/10 06:42 [medline]
PHST- 2023/06/11 01:06 [pubmed]
PHST- 2023/06/10 19:28 [entrez]
AID - S0048-9697(23)03378-8 [pii]
AID - 10.1016/j.scitotenv.2023.164755 [doi]
PST - ppublish
SO  - Sci Total Environ. 2023 Sep 20;892:164755. doi: 10.1016/j.scitotenv.2023.164755. 
      Epub 2023 Jun 8.