PMID- 37303294
OWN - NLM
STAT- MEDLINE
DCOM- 20230828
LR  - 20230829
IS  - 2162-3279 (Electronic)
VI  - 13
IP  - 8
DP  - 2023 Aug
TI  - Comparing indices of responsiveness for the Coma Near-Coma Scale with and without 
      pain items: An Exploratory study.
PG  - e3120
LID - 10.1002/brb3.3120 [doi]
LID - e3120
AB  - INTRODUCTION: This study aimed to establish the indices of responsiveness for the 
      Coma/Near-Coma (CNC) scale without (8 items) and with (10 items) pain test 
      stimuli. A secondary purpose was to examine whether the CNC 8 items and 10 items 
      differ when detecting change in neurobehavioral function. METHODS: We analyzed 
      CNC data from three studies of participants with disorders of consciousness: one 
      observational study and two intervention studies. We generated Rasch person 
      measures using the CNC 8 items and CNC 10 items for each participant at two time 
      points 14 +/- 2 days apart using Rasch Measurement Theory. We calculated the 
      distribution-based minimal clinically important difference (MCID) and minimal 
      detectable change using 95% confidence intervals (MDC(95) ). RESULTS: We used the 
      Rasch transformed equal-interval scale person measures in logits. For the CNC 8 
      items: Distribution-based MCID 0.33 SD = 0.41 logits and MDC(95)  = 1.25 logits. 
      For the CNC 10 items: Distribution-based MCID 0.33 SD = 0.37 logits and MDC(95) 
       = 1.03 logits. Twelve and 13 participants made a change beyond measurement error 
      (MDC(95) ) using the CNC 8-item and 10-item scales, respectively. CONCLUSION: Our 
      preliminary evidence supports the clinical and research utility of the CNC 8-item 
      scale for measuring the responsiveness of neurobehavioral function, and that it 
      demonstrates comparable responsiveness to the CNC 10-item scale without 
      administering the two pain items. The distribution-based MCID can be used to 
      evaluate group-level changes while the MDC(95) can support clinical, data-driven 
      decisions about an individual patient.
CI  - (c) 2023 The Authors. Brain and Behavior published by Wiley Periodicals LLC.
FAU - Weaver, Jennifer A
AU  - Weaver JA
AUID- ORCID: 0000-0002-3964-1441
AD  - Department of Occupational Therapy, College of Health and Human Sciences, 
      Colorado State University, Fort Collins, Colorado.
FAU - Pertsovskaya, Vera
AU  - Pertsovskaya V
AD  - Department of Clinical Research and Leadership, School of Medicine and Health 
      Sciences, The George Washington University, Washington, District of Columbia.
FAU - Tran, Jasmine
AU  - Tran J
AD  - Department of Occupational Therapy, College of Health and Human Sciences, 
      Colorado State University, Fort Collins, Colorado.
FAU - Kozlowski, Allan J
AU  - Kozlowski AJ
AD  - Mary Free Bed Rehabilitation Hospital, Grand Rapids, Michigan.
FAU - Guernon, Ann
AU  - Guernon A
AD  - Speech-Language Pathology Program, College of Nursing and Health Sciences, Lewis 
      University, Romeoville, Illinois.
AD  - Neuroplasticity in Neurorehabilitation Lab, Hines Veterans Affairs Hospital, 
      Hines, Illinois.
FAU - Bender Pape, Theresa
AU  - Bender Pape T
AD  - Neuroplasticity in Neurorehabilitation Lab, Hines Veterans Affairs Hospital, 
      Hines, Illinois.
AD  - Department of Physical Medicine and Rehabilitation, Northwestern University, 
      Feinberg School of Medicine, Chicago, Illinois.
FAU - Mallinson, Trudy
AU  - Mallinson T
AD  - Department of Clinical Research and Leadership, School of Medicine and Health 
      Sciences, The George Washington University, Washington, District of Columbia.
LA  - eng
PT  - Journal Article
PT  - Observational Study
DEP - 20230611
PL  - United States
TA  - Brain Behav
JT  - Brain and behavior
JID - 101570837
SB  - IM
MH  - Humans
MH  - *Coma/diagnosis
MH  - *Pain/diagnosis
MH  - Surveys and Questionnaires
PMC - PMC10454260
OTO - NOTNLM
OT  - brain injuries
OT  - consciousness disorders
OT  - pain
OT  - rehabilitation
EDAT- 2023/06/12 06:42
MHDA- 2023/08/28 06:42
PMCR- 2023/06/11
CRDT- 2023/06/12 03:52
PHST- 2023/05/25 00:00 [revised]
PHST- 2023/01/27 00:00 [received]
PHST- 2023/05/31 00:00 [accepted]
PHST- 2023/08/28 06:42 [medline]
PHST- 2023/06/12 06:42 [pubmed]
PHST- 2023/06/12 03:52 [entrez]
PHST- 2023/06/11 00:00 [pmc-release]
AID - BRB33120 [pii]
AID - 10.1002/brb3.3120 [doi]
PST - ppublish
SO  - Brain Behav. 2023 Aug;13(8):e3120. doi: 10.1002/brb3.3120. Epub 2023 Jun 11.