PMID- 37303648
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230919
IS  - 1943-8141 (Print)
IS  - 1943-8141 (Electronic)
IS  - 1943-8141 (Linking)
VI  - 15
IP  - 5
DP  - 2023
TI  - Huangqi Guizhi Wuwu decoction improves hemorheology and inhibits inflammatory 
      response after PCI for acute myocardial infarction.
PG  - 3686-3696
AB  - OBJECTIVE: To determine the impact of Huangqi Guizhi decoction of five 
      ingredients on hemorheology and inflammatory factors in patients with acute 
      myocardial infarction (AMI) after percutaneous coronary intervention (PCI). 
      METHODS: A total of 111 cases of AMI treated in Tongchuan Hospital of Traditional 
      Chinese Medicine from February 2019 to February 2022 were analyzed 
      retrospectively. Among them, 47 patients who received routine treatment were 
      assigned to the control group, while those who received Huangqi Guizhi decoction 
      of five ingredients in addition to the treatment of the control group were 
      assigned to the study group. The clinical efficacy in the two groups was 
      evaluated after therapy. The two groups were compared as to changes in serum 
      inflammatory factors [tumor necrosis factor-alpha (TNF-alpha), high-sensitivity 
      C-reactive protein (hs-CRP), and interleukin-6 (IL-6)] before and after therapy. 
      The two groups were also compared as to differences in fibrinogen, plasma 
      viscosity, whole blood low-shear viscosity (WBLSV), and whole blood high-shear 
      viscosity (WBHSV) before and after therapy. Left ventricular end-diastolic 
      dimension (LVEDD), left ventricular end-systolic diameter (LVESD), and left 
      ventricular ejection fraction (LVEF) in the two groups were evaluated. In 
      addition, the two groups were compared as to incidence of major adverse 
      cardiovascular events (MACE) in 6 months. Logistic regression analysis was 
      conducted to analyze the risk factors for MACE. RESULTS: The study group showed a 
      significantly higher treatment efficacy than the control group (P < 0.05). After 
      therapy, the study group had significantly lower levels of TNF-alpha, hs-CRP, IL-6, 
      fibrinogen, plasma viscosity, WBLSV, and WBHSV than the control group (all P < 
      0.05), and showed lower LVEDD and LVESD levels and a higher LVEF level than the 
      control group. According to logistic regression analysis, age, history of 
      diabetes mellitus (TM), New York Heart Association (NYHA) classification, hsCPR, 
      and LVEF were independent risk factors for MACE (all P < 0.05). CONCLUSION: 
      Huangqi Guizhi decoction of five ingredients contributes to higher efficacy in 
      AMI and has the effects of inhibiting the inflammation and hemorheology of 
      patients. In addition, age, history of TM, NYHA classification, hsCPR, and LVEF 
      were independent risk factors for MACE.
CI  - AJTR Copyright (c) 2023.
FAU - Dang, Meili
AU  - Dang M
AD  - Department of Encephalopathy, SUN Simiao Hospital of Beijing University of 
      Chinese Medicine (Tongchuan Hospital of Traditional Chinese Medicine) Tongchuan 
      727100, Shaanxi, China.
FAU - Zhao, Xiaorui
AU  - Zhao X
AD  - Department of Traditional Chinese Medicine, SUN Simiao Hospital of Beijing 
      University of Chinese Medicine (Tongchuan Hospital of Traditional Chinese 
      Medicine) Tongchuan 727100, Shaanxi, China.
FAU - Cao, Yu
AU  - Cao Y
AD  - Department of Cardiovascular, SUN Simiao Hospital of Beijing University of 
      Chinese Medicine (Tongchuan Hospital of Traditional Chinese Medicine) Tongchuan 
      727100, Shaanxi, China.
FAU - Guan, Xin
AU  - Guan X
AD  - Internal Medicine-Cardiovascular Department I, Xixian New District Central 
      Hospital (The Second Affiliated Hospital of Shaanxi University of Chinese 
      Medicine) Xianyang 712000, Shaanxi, China.
FAU - Liu, Yuxia
AU  - Liu Y
AD  - Department of Cardiovascular, SUN Simiao Hospital of Beijing University of 
      Chinese Medicine (Tongchuan Hospital of Traditional Chinese Medicine) Tongchuan 
      727100, Shaanxi, China.
LA  - eng
PT  - Journal Article
DEP - 20230515
PL  - United States
TA  - Am J Transl Res
JT  - American journal of translational research
JID - 101493030
PMC - PMC10250998
OTO - NOTNLM
OT  - Huangqi Guizhi decoction of five ingredients
OT  - acute myocardial infarction
OT  - hemorheology
OT  - inflammatory factors
OT  - percutaneous coronary intervention
COIS- None.
EDAT- 2023/06/12 06:42
MHDA- 2023/06/12 06:43
PMCR- 2023/05/15
CRDT- 2023/06/12 03:56
PHST- 2023/03/22 00:00 [received]
PHST- 2023/04/28 00:00 [accepted]
PHST- 2023/06/12 06:43 [medline]
PHST- 2023/06/12 06:42 [pubmed]
PHST- 2023/06/12 03:56 [entrez]
PHST- 2023/05/15 00:00 [pmc-release]
PST - epublish
SO  - Am J Transl Res. 2023 May 15;15(5):3686-3696. eCollection 2023.