PMID- 37304203
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230613
IS  - 2472-1972 (Electronic)
IS  - 2472-1972 (Linking)
VI  - 7
IP  - 7
DP  - 2023 Jun 5
TI  - Estimated Glucose Disposal Rate Predicts Renal Progression in Type 2 Diabetes 
      Mellitus: A Retrospective Cohort Study.
PG  - bvad069
LID - 10.1210/jendso/bvad069 [doi]
LID - bvad069
AB  - CONTEXT: Insulin resistance is a feature of type 2 diabetes mellitus (T2DM). The 
      estimated glucose disposal rate (eGDR), a validated marker for insulin 
      resistance, is associated with complications of diabetes, but few studies have 
      explored the relationship between eGDR and renal outcomes in T2DM. OBJECTIVE: 
      This study investigated the value of eGDR in predicting renal progression in 
      T2DM. METHODS: A total of 956 T2DM patients with a baseline estimated glomerular 
      filtration rate (eGFR) >/= 60 mL/min/1.73 m(2) and 5 years of follow-up were 
      enrolled. Primary outcomes were rapid eGFR decline, eGFR <60 mL/min/1.73 m(2), 
      and composite renal endpoint consisting of 50% eGFR decline, doubling of serum 
      creatinine, or end-stage renal disease. A continuous scale with restricted cubic 
      spline curves and a generalized linear model were applied to evaluate the 
      associations between eGDR and primary outcomes. RESULTS: Rapid eGFR decline was 
      experienced by 23.95% of patients, 21.97% with eGFR <60 mL/min/1.73 m(2), and 
      12.13% with the composite renal endpoint. The eGDR showed a relationship with 
      follow-up eGFR and percentage change in eGFR (P < .001). An eGDR <6.34 mg/kg/min 
      was an independent risk factor for rapid eGFR decline, eGFR < 
      60 mL/min/1.73 m(2), or the composite renal endpoint(P < .05). Compared with eGDR 
      of 5.65 approximately 6.91 mg/kg/min, eGDR levels >8.33 mg/kg/min decreased the risk of rapid 
      eGFR decline by 75%, eGFR < 60 mL/min/1.73 m(2) by 60%, and the composite renal 
      endpoint by 61%. Subgroup analysis was performed by sex, age, and diabetes 
      duration, which showed that eGDR was associated with primary outcomes. 
      CONCLUSION: Lower eGDR is a predictive factor for renal deterioration in T2DM 
      patients.
CI  - (c) The Author(s) 2023. Published by Oxford University Press on behalf of the 
      Endocrine Society.
FAU - Peng, Juan
AU  - Peng J
AUID- ORCID: 0000-0001-5154-3011
AD  - Department of Nephrology, The Third Xiangya Hospital, Central South University, 
      Changsha, Hunan 410013, China.
FAU - Li, Aimei
AU  - Li A
AD  - Department of Nephrology, The Third Xiangya Hospital, Central South University, 
      Changsha, Hunan 410013, China.
FAU - Yin, Liangqingqing
AU  - Yin L
AD  - Department of Nephrology, The Third Xiangya Hospital, Central South University, 
      Changsha, Hunan 410013, China.
FAU - Yang, Qi
AU  - Yang Q
AD  - Department of Nephrology, The Third Xiangya Hospital, Central South University, 
      Changsha, Hunan 410013, China.
FAU - Pan, Jinting
AU  - Pan J
AD  - Department of Nephrology, The Third Xiangya Hospital, Central South University, 
      Changsha, Hunan 410013, China.
FAU - Yi, Bin
AU  - Yi B
AUID- ORCID: 0000-0002-4972-1226
AD  - Department of Nephrology, The Third Xiangya Hospital, Central South University, 
      Changsha, Hunan 410013, China.
LA  - eng
PT  - Journal Article
DEP - 20230601
PL  - United States
TA  - J Endocr Soc
JT  - Journal of the Endocrine Society
JID - 101697997
PMC - PMC10251298
OTO - NOTNLM
OT  - estimated glomerular filtration rate
OT  - estimated glucose disposal rate
OT  - type 2 diabetes mellitus
EDAT- 2023/06/12 06:42
MHDA- 2023/06/12 06:43
PMCR- 2023/06/01
CRDT- 2023/06/12 04:05
PHST- 2022/11/01 00:00 [received]
PHST- 2023/06/12 06:43 [medline]
PHST- 2023/06/12 06:42 [pubmed]
PHST- 2023/06/12 04:05 [entrez]
PHST- 2023/06/01 00:00 [pmc-release]
AID - bvad069 [pii]
AID - 10.1210/jendso/bvad069 [doi]
PST - epublish
SO  - J Endocr Soc. 2023 Jun 1;7(7):bvad069. doi: 10.1210/jendso/bvad069. eCollection 
      2023 Jun 5.