PMID- 37304287
OWN - NLM
STAT- MEDLINE
DCOM- 20230622
LR  - 20230622
IS  - 1664-3224 (Electronic)
IS  - 1664-3224 (Linking)
VI  - 14
DP  - 2023
TI  - Bidirectional two-sample Mendelian randomization analysis reveals a causal effect 
      of interleukin-18 levels on postherpetic neuralgia risk.
PG  - 1183378
LID - 10.3389/fimmu.2023.1183378 [doi]
LID - 1183378
AB  - BACKGROUND: Postherpetic neuralgia (PHN) is a debilitating complication of herpes 
      zoster, characterized by persistent neuropathic pain that significantly impairs 
      patients' quality of life. Identifying factors that determine PHN susceptibility 
      is crucial for its management. Interleukin-18 (IL-18), a pro-inflammatory 
      cytokine implicated in chronic pain, may play a critical role in PHN development. 
      METHODS: In this study, we conducted bidirectional two-sample Mendelian 
      randomization (MR) analyses to assess genetic relationships and potential causal 
      associations between IL-18 protein levels increasing and PHN risk, utilizing 
      genome-wide association study (GWAS) datasets on these traits. Two IL-18 datasets 
      obtained from the EMBL's European Bioinformatics Institute database which 
      contained 21,758 individuals with 13,102,515 SNPs and Complete GWAS summary data 
      on IL-18 protein levels which contained 3,394 individuals with 5,270,646 SNPs. 
      The PHN dataset obtained from FinnGen biobank had 195,191 individuals with 
      16,380,406 SNPs. RESULTS: Our findings from two different datasets of IL-18 
      protein levels suggest a correlation between genetically predicted elevations in 
      IL-18 protein levels and an increased susceptibility to PHN.(IVW, OR and 95% CI: 
      2.26, 1.07 to 4.78; p = 0.03 and 2.15, 1.10 to 4.19; p =0.03, respectively), 
      potentially indicating a causal effect of IL-18 protein levels increasing on PHN 
      risk. However, we did not detect any causal effect of genetic liability to PHN 
      risk on IL-18 protein levels. CONCLUSION: These findings suggest new insights 
      into identifying IL-18 protein levels increasing at risk of developing PHN and 
      may aid in the development of novel prevention and treatment approaches for PHN.
CI  - Copyright (c) 2023 Liang and Fan.
FAU - Liang, Xiao
AU  - Liang X
AD  - Department of Anesthesiology, West China Hospital, Sichuan University, Chengdu, 
      Sichuan, China.
FAU - Fan, Yuchao
AU  - Fan Y
AD  - Department of Anesthesiology, Sichuan Clinical Research Center for Cancer, 
      Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, Affiliated Cancer 
      Hospital of University of Electronic Science and Technology of China, Chengdu, 
      China.
LA  - eng
PT  - Journal Article
DEP - 20230525
PL  - Switzerland
TA  - Front Immunol
JT  - Frontiers in immunology
JID - 101560960
RN  - 0 (Interleukin-18)
RN  - 0 (IL18 protein, human)
SB  - IM
MH  - Humans
MH  - Genome-Wide Association Study
MH  - Interleukin-18/genetics
MH  - Mendelian Randomization Analysis
MH  - *Neuralgia, Postherpetic/genetics
MH  - Quality of Life
PMC - PMC10247971
OTO - NOTNLM
OT  - bidirectional Mendelian randomization
OT  - genome-wide association study
OT  - herpes zoster
OT  - interleukin-18
OT  - postherpetic neuralgia
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2023/06/12 06:42
MHDA- 2023/06/13 06:42
PMCR- 2023/01/01
CRDT- 2023/06/12 04:06
PHST- 2023/03/10 00:00 [received]
PHST- 2023/05/15 00:00 [accepted]
PHST- 2023/06/13 06:42 [medline]
PHST- 2023/06/12 06:42 [pubmed]
PHST- 2023/06/12 04:06 [entrez]
PHST- 2023/01/01 00:00 [pmc-release]
AID - 10.3389/fimmu.2023.1183378 [doi]
PST - epublish
SO  - Front Immunol. 2023 May 25;14:1183378. doi: 10.3389/fimmu.2023.1183378. 
      eCollection 2023.